Results 51 to 60 of about 2,367,021 (309)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Influence of Adult Attachment on COVID-19 Vaccination Intention: The Mediating Roles of Help-Seeking Style and Professional Help-Seeking Behavior

open access: yesVaccines, 2022
Vaccination against COVID-19 is regarded as one of the most promising interventions to control the pandemic. This study aimed to examine whether adult attachment affects an individual’s COVID-19 vaccination intention and whether this relationship is ...
Junyu Lu, Runzan Zhang, Xinping Zhang
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Help-seeking for Suicidal Thoughts in the Poisoned Patients at Loghman Hakim Teaching Hospital in Tehran, Iran

open access: yesنشریه پرستاری ایران, 2020
Background & Aims: A history of suicide attempt is the most important risk factor for repeated and successful suicide. Seeking help is essential to access to proper mental healthcare services, and appropriate help-seeking could protect individuals ...
M Inanlou   +3 more
doaj  

Over-reassurance and undersupport after a 'false alarm': a systematic review of the impact on subsequent cancer symptom attribution and help seeking [PDF]

open access: yes, 2015
This literature review examined research into the impact of a previous 'all-clear' or non-cancer diagnosis following symptomatic presentation ('false alarm') on symptom attribution and delays in help seeking for subsequent possible cancer ...
Renzi, C, Wardle, J, Whitaker, KL
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Doctoral Students' Help Seeking Behaviors

open access: yesJournal of Effective Teaching in Higher Education
The qualitative data was collected from doctoral students on a weekly basis. Students were asked to complete a behavior log which consisted of 10 questions and inquired about their help-seeking and studying behaviors.
Deana Ford
doaj   +1 more source

Relationship between mental health literacy and professional psychological help-seeking attitudes in China: a chain mediation model

open access: yesBMC Psychiatry, 2023
Background Mental health literacy is considered an important factor in promoting professional psychological help-seeking attitudes. However, it is important to clarify the emotional and behavioral factors that underlie this association.
Jingyuan Yang   +4 more
doaj   +1 more source

Epistemic Cognitive Beliefs and Academic Help Seeking

open access: yesScientific Journal of King Faisal University: Humanities and Management Sciences, 2021
This study aims to identify the levels of Epistemic Cognitive Beliefs (ECB) and the behaviour of Academic Help Seeking (AHS) among secondary school students in Jordan and detect the ability of ECB to predict AHS behaviour.
Omar Atallah Al-Adamat
doaj   +1 more source

Pathways to Service Receipt: Modeling Parent Help-Seeking for Childhood Mental Health Problems [PDF]

open access: yes, 2014
Understanding parent appraisals of child behavior problems and parental help-seeking can reduce unmet mental health needs. Research has examined individual contributors to help-seeking and service receipt, but use of structural equation modeling (SEM) is
Mian, Nicholas D.
core   +1 more source

Home - About - Disclaimer - Privacy