FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Evaluation of the Conversations about Non-Suicidal Self-Injury Mental Health First Aid Course: Effects on Knowledge, Stigmatising Attitudes, Confidence and Helping Behaviour. [PDF]
Int J Environ Res Public Health, 2023 Bond KS +10 more
europepmc +1 more source
The ‘anti-social’ nature of prosocial research; a psychosocial critique
, 2010 This article provides a critical review of recent psychological articles on prosocial behaviour. Even though it focuses on a specific section of this literature – giving to charities and prosocial responses to humanitarian disasters – the paper aims to ...
Seu, Irene Bruna, Bruna Seu
core +1 more source
Still want to help? Interpersonal coordination's effects on helping behaviour after a 24 hour delay
, 2020 A fast-growing literature is establishing how moving in time together has pro-social consequences, though no work to date has explored the persistence of these effects over time.
Henson, Agnes +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Encouraging bystander helping behaviour in a violent incident: a virtual reality study using reinforcement learning. [PDF]
Sci Rep, 2022 Rovira A, Slater M.
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Evaluation of the Conversations About Gambling Mental Health First Aid course: effects on knowledge, stigmatising attitudes, confidence and helping behaviour. [PDF]
BMC Psychol, 2022 Bond KS +9 more
europepmc +1 more source
Reproductive constraints, direct fitness and indirect fitness benefits explain helping behaviour in the primitively eusocial wasp, Polistes canadensis [PDF]
, 2010 A key step in the evolution of sociality is the abandonment of independent breeding in favour of helping. In cooperatively breeding vertebrates and primitively eusocial insects, helpers are capable of leaving the group and reproducing independently, and ...
H. Kelstrup +6 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source