Results 111 to 120 of about 52,296 (305)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Jurnal Ilmiah Bimbingan Konseling Undiksha, 2014 Penelitian ini bertujuan untuk mengetahui penerapan konseling rasional emotif dengan teknik reframing dalam meminimalisir learned helplessness pada siswa kelas XI IPA 3 SMA Negeri 3 Singaraja.
Kadek Lusiani Laksmi +2 more
doaj +1 more source
The Antecedents and Consequences of Learned Helplessness in Work Life [PDF]
, 2012 Technologies, processes and products are easily imitated in today’s business world, so organizations can differentiate themselves from others only with their human capital.
Tayfur, Ozge
core +2 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Frontiers in Aging NeuroscienceBackgroundThis study focuses on how elements of depression correlate with mild cognitive impairment (MCI) in older adults and the diagnostic efficacy of combining these components with the Mini-Mental State Examination (MMSE). The study also investigated
Boung Chul Lee +12 more
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Measuring Learned Helplessness: A Psychometric Approach [PDF]
, 2009 "Learned helplessness, a well established principle in Psychology is a cognitive state of an individual that makes' him/her believes that nothing he does can change his/her situation. Owing to the absence of a direct psychometric based measure of learned
Olapegba ., P. O
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Self-Defeating Personality and Learned Helplessness [PDF]
, 1999 This study attempted to determine whether people who engage in a higher frequency of self-defeating behaviors show a greater degree of those characteristics which define learned helplessness.
Kabatay, Regina T.
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source