Results 41 to 50 of about 13,617,784 (317)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

Advanced Science, EarlyView.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu, Chen‐Xi Yue, Wen‐Zhong Dong, Cui‐Yun Hao, Yi‐Fan Qiao, Di Liu, Xin Zhang, Qi Zhan, Jia‐Bao Yao, Dong‐Ping Wang, Peng Cao, Ying‐Zhe Fan, Ye Yu   +12 more
wiley   +1 more source

Smoking and serological response to influenza vaccine

Human Vaccines & Immunotherapeutics
Cigarette smoking confers additional risk from influenza. This study assessed the effect of smoking on humoral immune response to influenza vaccine. Adults ≥50 y of age were enrolled during the 2011–2016 influenza vaccination seasons in an observational ...
Won Suk Choi, Mary Patricia Nowalk, Krissy Moehling Geffel, Michael Susick, Sean Saul, Chyongchiou Jeng Lin, Ted M. Ross, Richard K. Zimmerman   +7 more
doaj   +1 more source

Aquarium dermatitis: Cercarial dermatitis in an aquarist [PDF]

, 1998
A 33-year-old man presented with very itchy red papules on the back of his hands and forearms. These papules appeared about 90 min after he had cleaned his aquarium in which he kept native fish and watersnails.
Bastert, J., Korting, Hans Christian, Sing, A., Wollenberg, A.   +3 more
core   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, EarlyView.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Isolation of Two Strains of West Nile Virus during an Outbreak in Southern Russia, 1999

Emerging Infectious Diseases, 2000
From July to September 1999, a widespread outbreak of meningoencephalitis associated with West Nile virus (Flavivirus, Flaviviridae) occurred in southern Russia, with hundreds of cases and dozens of deaths.
D.K. Lvov, A.M. Butenko, V.L. Gromashevsky, V.Ph. Larichev, S.Ya. Gaidamovich, O.I. Vyshemirsky, A.N. Zhukov, V.V. Lazorenko, V.N. Salko, A.I. Kovtunov, Kh.M. Galimzyanov, A.E. Platonov, T.N. Morozova, N.V. Khutoretskaya, E.O. Shishkina, T.M. Skvortsova   +15 more
doaj   +1 more source

A rapid and affordable point of care test for antibodies against SARS-CoV-2 based on hemagglutination and artificial intelligence interpretation

Scientific Reports, 2021
Diagnostic tests that detect antibodies (AB) against SARS-CoV-2 for evaluation of seroprevalence and guidance of health care measures are important tools for managing the COVID-19 pandemic. Current tests have certain limitations with regard to turnaround
Vanessa Redecke, Kazuki Tawaratsumida, Erin T. Larragoite, Elizabeth S. C. P. Williams, Vicente Planelles, Adam M. Spivak, Lincoln Hirayama, Marc Elgort, Shane Swenson, Rick Smith, Bryan Worthen, Russ Zimmerman, Patricia Slev, Ben Cahoon, Mark Astill, Hans Häcker   +15 more
doaj   +1 more source

Application of a ddRT-PCR to quantify seasonal influenza virus for viral isolation

Biosafety and Health, 2022
Viral isolation in cell cultures has been regarded for decades as the “gold standard” for the laboratory diagnosis of influenza viral infections. Not all viral strains could be isolated from clinical samples.
Yimeng Liu, Jiachen Zhao, Xiaomin Peng, Guilan Lu, Weixian Shi, Zhaomin Feng, Hui Xu, Shujuan Cui, Yang Pan, Daitao Zhang, Peng Yang, Quanyi Wang   +11 more
doaj   +1 more source

Antigenicity of chlorpromazine and clozapine to rabbits [PDF]

, 1970
Antigenicity of clozapine was studied in rabbits, comparing with that of chlorpromazine as control. The results indicate that chlorpromazine produces antibody in rabbit as revealed by passive hemagglutination test, giving the titer of 1 : 2, 000 or ...
Seno, Satimaru, Tada, Hiroshi, Ueki, Ayako   +2 more
core   +1 more source