Results 111 to 120 of about 23,124 (216)

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies [PDF]

, 2016
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and
Callewaert, Nico, Fiers, Walter, Saelens, Xavier, Schepens, Bert, Schotsaert, Michael, Smet, Anouk, Stegalkina, Svetlana, Vanderschaeghe, Dieter, Vogel, Thorsten U, Ysenbaert, Tine   +9 more
core   +2 more sources

Advancing ORFV‐Based Therapeutics to the Clinical Stage

Reviews in Medical Virology, Volume 35, Issue 3, May 2025.
ABSTRACT The Orf virus (ORFV) is the prototype member of the parapoxvirus family and has long been recognized for its robust immunogenicity, favourable safety profile and its ability to stimulate both cellular and humoural immune responses without inducing significant anti‐vector immunity.
Matthias Helmold, Ralf Amann
wiley   +1 more source

Correction: An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism

PLOS Pathogens, 2016
Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated sialic acids as its receptor for virus entry.
Song, Hao, Qi, Jianxun, Khedri, Zahra, Diaz, Sandra, Yu, Hai, Chen, Xi, Varki, Ajit, Shi, Yi, Gao, George F   +8 more
openaire   +5 more sources

Shrinkage-based random local clocks with scalable inference [PDF]

arXiv, 2021
Local clock models propose that the rate of molecular evolution is constant within phylogenetic sub-trees. Current local clock inference procedures scale poorly to large taxa problems, impose model misspecification, or require a priori knowledge of the existence and location of clocks.
arxiv  

Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail [PDF]

, 1986
Truncated variants of the gene encoding H-2Ld, an integral membrane protein encoded by the major histocompatibility complex, were constructed by in vitro mutagenesis to elucidate the function of charged amino acids found on the cytoplasmic side of the ...
Hood, Leroy E., Zuñiga, Martha C.
core  

Your Best Shot at Surviving the Flu Season [PDF]

, 2020
Millions of individuals become ill from the influenza virus every year. As an existing public health issue, it is important for patients to understand that the best way to combat the influenza virus is through prevention.
Liu, Isabella
core   +1 more source

Molecular Evolution of Influenza A Viruses From Mauritius, 2017–2019

Influenza and Other Respiratory Viruses, Volume 19, Issue 5, May 2025.
ABSTRACT Background Despite being a vaccine preventable disease, influenza remains a burden in African countries. In Mauritius, influenza virus activity is year‐round but evidence‐based data to guide vaccination and pandemic preparedness strategies are lacking.
Magalutcheemee Ramuth, Janaki Sonoo, Fhooblall Mokshanand, Belinda Herring, Tessema Sofonias, John McCauley, Ashwamed Dinasing, Florette K. Treurnicht   +7 more
wiley   +1 more source

Quantifying Selection and Diversity in Viruses by Entropy Methods, with Application to the Hemagglutinin of H3N2 Influenza [PDF]

J. R. Soc. Interface, 7 (2011) 1644-1653, 2012
Many viruses evolve rapidly. For example, hemagglutinin of the H3N2 influenza A virus evolves to escape antibody binding. This evolution of the H3N2 virus means that people who have previously been exposed to an influenza strain may be infected by a newly emerged virus. In this paper, we use Shannon entropy and relative entropy to measure the diversity
arxiv  

Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium

Advanced Biology, Volume 9, Issue 4, April 2025.
The infectious potential of respiratory viruses depends on their ability to navigate through a layer of mucus that serves as a protective barrier in the lung. It is demonstrated that influenza A virus penetration through mucus is significantly limited by the gel's internal microstructure and, to a lesser extent, by adhesive binding to mucin glycans ...
Logan Kaler, Elizabeth M. Engle, Maria Corkran, Ethan Iverson, Allison Boboltz, Maxinne A. Ignacio, Taj Yeruva, Margaret A. Scull, Gregg A. Duncan   +8 more
wiley   +1 more source

A single cycle influenza virus coated in H7 hemagglutinin provides heterotypic protection and neutralising antibody responses to both glycoproteins

, 2017
AbstractA non-replicating form of pseudotyped influenza virus, inactivated by suppression of the hemagglutinin signal sequence (S-FLU), can act as a broadly protective vaccine. S-FLU can infect for a single round only, and induces heterotypic protection predominantly through activation of cross-reactive T cells in the lung.
Powell, Timothy J, Rijal, Pramila, McEwen-Smith, Rosanna M, Byun, Haewon, Hardwick, Marc, Schimanski, Lisa M, Huang, Kuan-Ying A, Daniels, Rodney S, Townsend, Alain R M   +8 more
openaire   +3 more sources