Results 131 to 140 of about 23,124 (216)
Post-translational processing of the glycoproteins of lymphocytic choriomeningitis virus. [PDF]
, 1990 Intracellular events in the synthesis, glycosylation, and transport of the lymphocytic choriomeningitis virus (LCMV) glycoproteins have been examined. We have shown by N-glycanase digestion that LCMV strain Arm-4 bears five oligosaccharides on GP-1 and ...
Buchmeier, MJ +3 more
core
Reconstruction of H3N2 influenza virus based virosome in-vitro
Iranian Journal of Microbiology, 2013 Background and Objectives: Virosomes are Virus Like Particles (VLP) assembled in-vitro. Influenza virosomes maintain the cell binding and membrane fusion activity of the wild type virus but are devoid of viral genetic material or internal proteins ...
Asghar Abdoli +6 more
doaj
Hierarchical hydropathic evolution of influenza glycoproteins (N2, H3, A/H3N2) under relentless vaccination pressure [PDF]
arXiv, 2013 Hemagglutinin (HA) and neuraminidase (NA) are highly variable envelope glycoproteins. Here hydropathic analysis, previously applied to quantify common flu (H1N1) evolution (1934-), is applied to the evolution of less common but more virulent (avian derived) H3N2 (1968-), beginning with N2.
arxiv
Viruses, 2016 The fusion glycoproteins that decorate the surface of enveloped viruses undergo dramatic conformational changes in the course of engaging with target cells through receptor interactions and during cell entry.
Natalie K. Garcia, Kelly K. Lee
doaj +1 more source
Snapshot of an influenza virus glycoprotein fusion intermediate
Cell Reports, 2021 Summary: Enveloped virus entry requires the fusion of cellular and viral membranes, a process directed by their viral fusion glycoproteins. Our current knowledge of this process has been shaped by structural studies of the pre- and post-fusion ...
Vitor Hugo B. Serrão +2 more
doaj
Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N2
Virology Journal, 2009 Background Avian influenza viruses (AIV) cause high morbidity and mortality among the poultry worldwide. Their highly mutative nature often results in the emergence of drug resistant strains, which have the potential of causing a pandemic.
Rajik Mohamed +5 more
doaj +1 more source
A Novel Sequence-Based Antigenic Distance Measure for H1N1, with Application to Vaccine Effectiveness and the Selection of Vaccine Strains [PDF]
Protein Engineering, Design & Selection 24 (2011) 291-299, 2012 H1N1 influenza causes substantial seasonal illness and was the subtype of the 2009 influenza pandemic. Precise measures of antigenic distance between the vaccine and circulating virus strains help researchers design influenza vaccines with high vaccine effectiveness.
arxiv
Stochastic model of endosomal escape of Influenza virus [PDF]
arXiv, 2015 Influenza viruses enter a cell via endocytosis after binding to the surface. During the endosomal journey, acidification triggers a conformational change of the virus spike protein hemagglutinin (HA) that results in escape of the viral genome from the endosome to the cytoplasm.
arxiv
PLoS Pathogens, 2016 Determining phenotype from genetic data is a fundamental challenge. Identification of emerging antigenic variants among circulating influenza viruses is critical to the vaccine virus selection process, with vaccine effectiveness maximized when ...
William T Harvey +9 more
doaj +1 more source
Epitope analysis for influenza vaccine design [PDF]
arXiv, 2004 Until now, design of the annual influenza vaccine has relied on phylogenetic or whole-sequence comparisons of the viral coat proteins hemagglutinin and neuraminidase, with vaccine effectiveness assumed to correlate monotonically to the vaccine-influenza sequence difference. We use a theory from statistical mechanics to quantify the non-monotonic immune
arxiv