Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies [PDF]
, 2014 The increased number of outbreaks of H5 and H7 LPAI and HPAI viruses in poultry has major public and animal health implications. The continuous rapid evolution of these subtypes and the emergence of new variants influence the ability to undertake ...
Cattoli, G. +11 more
core +6 more sources
The post-2009 influenza pandemic era : time to revisit antibody immunodominance [PDF]
, 2018 The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift ...
Caton +6 more
core +1 more source
Viruses, 2017 Currently licensed vaccines against the influenza A virus (IAV) need to be updated annually to match the constantly evolving antigenicity of the influenza virus glycoproteins, hemagglutinin (HA), and neuramidiase (NA).
Eun Hye Kim, Gye-Yeong Han, Huan Nguyen
doaj +1 more source
Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses [PDF]
, 2015 Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies.
arxiv +1 more source
Multi-channel neural networks for predicting influenza A virus hosts and antigenic types [PDF]
arXiv, 2022 Influenza occurs every season and occasionally causes pandemics. Despite its low mortality rate, influenza is a major public health concern, as it can be complicated by severe diseases like pneumonia. A fast, accurate and low-cost method to predict the origin host and subtype of influenza viruses could help reduce virus transmission and benefit ...
arxiv
Genetic characterization of influenza A(H3N2) viruses circulating in coastal Kenya, 2009-2017 [PDF]
, 2020 Background Influenza viruses evolve rapidly and undergo immune driven selection, especially in the hemagglutinin (HA) protein. We report amino acid changes affecting antigenic epitopes and receptor‐binding sites of A(H3N2) viruses circulating in Kilifi,
Agoti, Charles N. +8 more
core +1 more source
PLoS ONE, 2018 Influenza viruses are by nature unstable with high levels of mutations. The sequential accumulation of mutations in the surface glycoproteins allows the virus to evade the neutralizing antibodies.
Agustiningsih Agustiningsih +5 more
doaj +1 more source
Vaccine escape in 2013-4 and the hydropathic evolution of glycoproteins of A/H3N2 viruses [PDF]
, 2015 More virulent strains of influenza virus subtypes H1N1 appeared widely in 2007 and H3N2 in 2011, and especially 2013-4, when the effectiveness of the H3N2 vaccine decreased nearly to zero. The amino acid differences of neuraminidase from prior less virulent strains appear to be small (<1%) when tabulated through sequence alignments and counting site ...
arxiv +1 more source
Classification of Influenza Hemagglutinin Protein Sequences using Convolutional Neural Networks [PDF]
arXiv, 2021 The Influenza virus can be considered as one of the most severe viruses that can infect multiple species with often fatal consequences to the hosts. The Hemagglutinin (HA) gene of the virus can be a target for antiviral drug development realised through accurate identification of its sub-types and possible the targeted hosts.
arxiv
Rapid preparation of mutated influenza hemagglutinins for influenza virus pandemic prevention [PDF]
, 2016 Influenza viruses have periodically caused pandemic due to frequent mutation of viral proteins. Influenza viruses have two major membrane glycoproteins: hemagglutinin (HA) and neuraminidase (NA).
Kuroda, Kouichi +4 more
core +1 more source