Influenza hemagglutinin membrane anchor [PDF]
Proceedings of the National Academy of Sciences, 2018 Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies.
Donald J. Benton +12 more
openaire +4 more sources
Viral factors in influenza pandemic risk assessment [PDF]
eLife, 2016 The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans.
Marc Lipsitch +18 more
doaj +6 more sources
Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin [PDF]
, 2014 Influenza viruses continuously undergo antigenic changes with gradual accumulation of mutations in hemagglutinin (HA) that is a major determinant in subtype specificity.
Cho, Ki Joon +7 more
core +15 more sources
Global Prevalence and Hemagglutinin Evolution of H7N9 Avian Influenza Viruses from 2013 to 2022
Viruses, 2023 H7N9 avian influenza viruses have caused severe harm to the global aquaculture industry and human health. For further understanding of the characteristics of prevalence and hemagglutinin evolution of H7N9 avian influenza viruses, we generated the global ...
Qianshuo Liu +4 more
doaj +1 more source
Mitogenicity of influenza hemagglutinin glycoproteins and influenza viruses bearing H2-hemagglutinin [PDF]
Infection and Immunity, 1981 The hemagglutinin glycoprotein is responsible for the mitogenic effect of influenza A viruses of the H2N2 subtype. This was indicated by the ability of viruses bearing the H2-hemagglutinin glycoprotein, regardless of its associated neuraminidase, to induce lymphocyte proliferation in normal spleen cell suspensions and by the ability of antisera with ...
R B, Armstrong +4 more
openaire +2 more sources
Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions
Viruses, 2021 In current seasonal influenza vaccines, neutralizing antibody titers directed against the hemagglutinin surface protein are the primary correlate of protection. These vaccines are, therefore, quantitated in terms of their hemagglutinin content.
Nidhi Mittal +9 more
doaj +1 more source
Influenza C virus hemagglutinin: comparison with influenza A and B virus hemagglutinins [PDF]
Journal of Virology, 1984 The complete nucleotide sequence of the influenza C/California/78 virus RNA 4 was obtained by using cloned cDNA derived from the RNA segment. This gene is 2,071 nucleotides long and can code for a polypeptide of 654 amino acids. Although there are no convincing sequence homologies between RNA 4 and the hemagglutinin genes of influenza A and B viruses ...
S, Nakada +4 more
openaire +2 more sources
FluBlok, a recombinant hemagglutinin influenza vaccine [PDF]
Influenza and Other Respiratory Viruses, 2008 Abstract FluBlok, a recombinant trivalent hemagglutinin (HA) vaccine produced in insect cell culture using the baculovirus expression system, provides an attractive alternative to the current egg‐based trivalent inactivated influenza vaccine (TIV) manufacturing process.
Cox, Manon M.J. +2 more
openaire +2 more sources
Hydrophobin fusion of an influenza virus hemagglutinin allows high transient expression in Nicotiana benthamiana, easy purification and immune response with neutralizing activity. [PDF]
PLoS ONE, 2014 The expression of recombinant hemagglutinin in plants is a promising alternative to the current egg-based production system for the influenza vaccines. Protein-stabilizing fusion partners have been developed to overcome the low production yields and the ...
Nicolas Jacquet +3 more
doaj +1 more source
Ветеринария сегодня, 2021 At the end of 2020, a large-scale bird death was registered at one of the poultry farms in the Astrakhan region, the cause of which was avian influenza.
N. G. Zinyakov +6 more
doaj +1 more source