Results 101 to 110 of about 311,423 (321)

Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus [PDF]

, 2018
Aim: The only small molecule drugs currently available for treatment of influenza A virus (IAV) are M2 ion channel blockers and sialidase inhibitors. The prototype thiazolide, nitazoxanide, has successfully completed Phase III clinical trials against ...
Andrew V Stachulski, Brian M Eklov, Chandrakala Pidathala, Eleanor C Row, Giuseppe Belardo, J Edward Semple, Jean-Francois Rossignol, La Frazia S, M Gabriella Santoro, Mazhar Iqbal, Neil G Berry, Paul M O'Neill, Podlogar BL, Rossignol JF, Rossignol JF, Sara Piacentini, Sarah A Allman, Simone La Frazia   +17 more
core   +1 more source

Hemolysis by Liposomes Containing Influenza Virus Hemagglutinins [PDF]

Journal of Virology, 1983
Liposomes containing influenza virus hemagglutinin were reassembled from envelopes solubilized with Nonidet P-40 and were shown to induce hemolysis and cell fusion at low pH.
Y, Hosaka, Y, Yasuda, K, Fukai
openaire   +2 more sources

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Influenza hemagglutinin: kinetic control of protein function [PDF]

Structure, 1994
In response to decreased pH, influenza hemagglutinin changes to a more stable conformation. Such changes, which can be controlled thermodynamically or kinetically, are the method by which many biological 'switches' are thrown.
D, Baker, D A, Agard
openaire   +2 more sources

Medical Gas Plasma Inactivates Adenoviruses via Capsid Oxidation

Small, EarlyView.
Oxidative modification of three adenoviral capsid proteins after gas plasma treatment. Schematic representation of the viral infection process, starting with the initial attachment of the virus via its fiber protein binding to the cellular receptors (CAR and/or CD46). In the secondary attachment step, the penton base binds to integrin structures on the
Anke Schmidt, Meike Heuser, Paul Schulan, Lea Miebach, Alice Martinet, Marcus Frank, Kristian Wende, Sander Bekeschus   +7 more
wiley   +1 more source

Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

Science, 2018
Durable influenza protection Vaccines are indispensable for the control and prevention of influenza, but there are several challenges to efficacy. Some individuals respond poorly to vaccination, and virus variation makes targeting optimal antigens ...
N. S. Laursen, R. Friesen, Xueyong Zhu, M. Jongeneelen, Sven Blokland, J. Vermond, Alida van Eijgen, Chan Tang, Harry van Diepen, G. Obmolova, M. van der Neut Kolfschoten, D. Zuijdgeest, R. Straetemans, Ryan M. B. Hoffman, Travis Nieusma, J. Pallesen, H. Turner, S. Bernard, A. Ward, Jinquan Luo, L. Poon, A. Tretiakova, James M. Wilson, M. Limberis, R. Vogels, Boerries Brandenburg, J. Kolkman, I. Wilson   +27 more
semanticscholar   +1 more source

The evaluation of the possibility of the estimation the amount of hemagglutininin in the final lots of inactivated adjuvanted influenza vaccines

Вопросы вирусологии
Introduction. The main quality indicator for inactivated influenza vaccines is their potency (the amount of hemagglutinin). The potency test for the influenza vaccine with the SOVIDON adjuvant is carried out in a trivalent bulk vaccine before the ...
Aleksey Y. Butirskiy, Elena N. Morozova, Karine A. Sarkisyan   +2 more
doaj   +1 more source

Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities

Virology Journal, 2009
Background Influenza virus infection causes significant morbidity and mortality and has marked social and economic impacts throughout the world. The influenza surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA), act cooperatively to support ...
Suzuki Takashi, Takahashi Tadanobu, Hiramatsu Hiroaki, Wilairat Prapon, Sriwilaijaroen Nongluk, Ito Morihiro, Ito Yasuhiko, Tashiro Masato, Suzuki Yasuo   +8 more
doaj   +1 more source

Selective Wettability–Driven Evaporation‐Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles

Small Methods, EarlyView.
ABSTRACT Timely detection of viral infections, particularly in settings outside centralized laboratories, is essential for controlling outbreaks. Small electrochemical biosensors are appealing because they are fast, require microliter sample volumes, and can be integrated into portable devices.
Pouya Soltan Khamsi, Shubhada K Chothe, Suresh V Kuchipudi, Aida Ebrahimi   +3 more
wiley   +1 more source

Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance A key goal in the study of influenza virus evolution is to forecast which viral strains will persist and which ones will die out. Here we experimentally measure the effects of all amino acid mutations to the hemagglutinin protein from a ...
Juhye M. Lee, J. Huddleston, Michael B. Doud, K. Hooper, N. Wu, T. Bedford, J. Bloom   +6 more
semanticscholar   +1 more source