Results 111 to 120 of about 311,423 (321)

Complexes of Oligoribonucleotides with D-Mannitol Inhibit Hemagglutinin–Glycan Interaction and Suppress Influenza A Virus H1N1 (A/FM/1/47) Infectivity In Vitro

open access: yesPharmaceuticals, 2017
The influenza virus hemagglutinin (HA) mediates both receptor (glycan) binding and membrane fusion for cell entry and has been the basis for subtyping influenza viruses.
Nataliia Melnichuk   +2 more
doaj   +1 more source

TIV vaccination modulates host responses to influenza virus infection that correlate with protection against bacterial superinfection [PDF]

open access: yes, 2019
Background: Influenza virus infection predisposes to secondary bacterial pneumonia. Currently licensed influenza vaccines aim at the induction of neutralizing antibodies and are less effective if the induction of neutralizing antibodies is low and/or the
Choi, Angela   +4 more
core   +2 more sources

Studies on Vaccination of Infants Against Influenza with Influenza Hemagglutinin

open access: yesExperimental Biology and Medicine, 1974
SummaryInfants 2-6 mo of age were given 3 doses of influenza hemagglutinin vaccine. One group received 250 CCA units of vaccine at intervals of 1 mo. A second group was given 250 CCA units with an interval of 2 mo between the first and second dose and an interval of 1 mo between the second and third dose.
A V, Hennessy, F M, Davenport
openaire   +2 more sources

Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

open access: yesMicrobiology and Immunology, EarlyView.
ABSTRACT Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their strong safety profile and broad range of target groups; however ...
Nantaporn Kaewaroon   +4 more
wiley   +1 more source

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

open access: yesNature Communications, 2018
Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus
N. Pardi   +13 more
semanticscholar   +1 more source

Reassortant Pandemic (H1N1) 2009 Virus in Pigs, United Kingdom

open access: yesEmerging Infectious Diseases, 2011
Surveillance for influenza virus in pigs in the United Kingdom during spring 2010 detected a novel reassortant influenza virus. This virus had genes encoding internal proteins from pandemic (H1N1) 2009 virus and hemagglutinin and neuraminidase genes from
Wendy A. Howard   +6 more
doaj   +1 more source

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

open access: yes, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet   +27 more
core   +1 more source

Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues

open access: yesCell Proliferation, EarlyView.
H1N1 infection during pregnancy specifically targets the fetal liver and lungs, triggering immune responses, tissue fibrosis and ferroptosis in parenchymal cells, ultimately leading to adverse pregnancy outcomes, offering insights into managing maternal H1N1 infections and their impact on fetal health.
Yuxi Jiang   +11 more
wiley   +1 more source

How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin

open access: yesNature Communications, 2018
Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so.
Michael B. Doud, Juhye M. Lee, J. Bloom
semanticscholar   +1 more source

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]

open access: yes, 2014
Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora   +9 more
core   +1 more source

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