Results 121 to 130 of about 311,423 (321)

Factors Affecting Immune Reconstitution Post‐Allogeneic HSCT in Children: The Case for an Individualized Approach to Vaccination

European Journal of Haematology, EarlyView.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used to treat malignant and non‐malignant diseases. Following allogeneic HSCT, patients are particularly vulnerable to vaccine‐preventable diseases (VPD) because conditioning depletes immune cells, including memory cells.
Hélène Buvelot, Frederic Baleydier, Laure Pittet, Geraldine Blanchard‐Rohner   +3 more
wiley   +1 more source

Chemoenzymatically Synthesized O‐Acetylated GD3 Gangliosides to Examine Viral Receptor Specificities in a Cellular Context

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
7‐O‐, 9‐O‐, and 7,9‐di‐O‐acetylated GD3 gangliosides can be prepared by chemical assembly of a tetrasaccharide as α‐glycosyl fluoride that is coupled to sphingosine using a glycosynthase, followed by O‐acetyl editing by coronaviral hemagglutinin‐esterases (HEs).
Zhiyong Zhang, Ruonan Liang, Kevin C. Hooijschuur, Robert P. de Vries, Zeshi Li, Geert‐Jan Boons   +5 more
wiley   +2 more sources

Heterogeneity of the MDCK cell line and its applicability for influenza virus research.

PLoS ONE, 2013
Single-cell clones have been established from the MDCK cell line, characterized for their morphology and evaluated for their suitability for influenza virus research. Three discrete cell morphotypes were identified using light microscopy.
Vladimir Y Lugovtsev, Darya Melnyk, Jerry P Weir   +2 more
doaj   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

The influenza virus hemagglutinin head evolves faster than the stalk domain

Scientific Reports, 2018
The limited ability of current influenza virus vaccines to protect from antigenically drifted or shifted viruses creates a public health problem that has led to the need to develop effective, broadly protective vaccines.
Ericka Kirkpatrick, Xueting Qiu, P. Wilson, J. Bahl, F. Krammer   +4 more
semanticscholar   +1 more source

Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles [PDF]

, 2002
BACKGROUND: Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV ...
A Nicholls, A Robert Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AS Dimitrov, Asim K Debnath, CE Parker, CH Chen, CM Carr, CM Carr, DC Chan, DC Chan, DL LeDuc, DR Littman, E de Rosny, EG Cormier, EG Cormier, GB Melikyan, H Deng, I Munoz-Barroso, J Bentz, J Chen, JA McKeating, JJ Skehel, K Tan, KH Manson, M Farzan, M Lu, M Thali, MK Gorny, Nathan Strick, P Lusso, PD Kwong, PL Jones, QJ Sattentau, QJ Sattentau, QJ Sattentau, R Wyatt, R Wyatt, RA Furuta, RL Willey, RW Doms, S Gartner, S Jiang, S Jiang, SA Gallo, Shibo Jiang, SL Orloff, SP Layne, T Gyotoku, T Kawamura, T Korte, T Weber, T-C Chou, TN Hart, U Moebius, VA Johnson, W Weissenhorn, W Weissenhorn, X-Z Pan, Y Kliger, Yun-Yao Li   +67 more
core   +3 more sources

The generation of hemagglutinin monoclonal antibodies against H9N2 influenza virus [PDF]

, 2023
Yongcheng Duan, Qingli Guo, Shaoyu Tu, Jiahui Zou, Guohong Li, Liang Cheng, Yanqing Cheng, Yijie Zhou, Lin Chen, Yuanbao Zhou, Sizhu Suolang, Hongbo Zhou   +11 more
openalex   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

mBio, 2018
Current influenza vaccines are primarily strain specific, requiring annual updates, and offer minimal protection against drifted seasonal or pandemic strains. The highly conserved stem region of hemagglutinin (HA) of group 2 influenza A virus subtypes is
Kizzmekia S. Corbett, Syed M. Moin, Hadi M. Yassine, A. Cagigi, M. Kanekiyo, Seyhan Boyoglu-Barnum, Sky Myers, Y. Tsybovsky, A. Wheatley, Chaim A. Schramm, Rebecca A. Gillespie, W. Shi, Lingshu Wang, Yi Zhang, Sarah F. Andrews, M. Joyce, M. Crank, D. Douek, A. McDermott, J. Mascola, B. Graham, J. Boyington   +21 more
semanticscholar   +1 more source

A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.

PLoS ONE, 2012
Recently, a new class of broadly neutralizing anti-influenza virus antibodies that target the stalk domain of the viral hemagglutinin was discovered. As such, induction, isolation, characterization, and quantification of these novel antibodies has become
Florian Krammer, Irina Margine, Gene S Tan, Natalie Pica, Jens C Krause, Peter Palese   +5 more
doaj   +1 more source