Results 141 to 150 of about 311,423 (321)

Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin

mBio, 2017
Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observed to
Naganori Nao, J. Yamagishi, H. Miyamoto, Manabu Igarashi, Rashid Manzoor, Aiko Ohnuma, Yoshimi Tsuda, Wakako Furuyama, Asako Shigeno, M. Kajihara, N. Kishida, R. Yoshida, A. Takada   +12 more
semanticscholar   +1 more source

Development of a high density hemagglutinin protein microarray to determine the breadth of influenza antibody responses

BioTechniques, 2013
We have developed an influenza hemagglutinin protein microarray to assess humoral recognition of diverse influenza strains induced by vaccination and infection.
Anthony L. Desbien, Neal Van Hoeven, Steven J. Reed, Allen C. Casey, John D. Laurance, Susan L. Baldwin, Malcolm S. Duthie, Steven G. Reed, Darrick Carter   +8 more
doaj   +1 more source

Insertions of codons encoding basic amino acids in H7 hemagglutinins of influenza A viruses occur by recombination with RNA at hotspots near snoRNA binding sites [PDF]

, 2020
Alexander P. Gultyaev, Monique I. Spronken, Mathis Funk, Ron A. M. Fouchier, Mathilde Richard   +4 more
openalex   +1 more source

Influence of Influenza Hemagglutinin on Hemolysis Rates

Experimental Biology and Medicine, 1952
Summary1. The rates of lysis of guinea pig red cells by sodium choleate are altered by the adsorption and spontaneous detachment (“elution”) of purified PR-8 influenza virus hemagglutinin. During the adsorption phase, lysis is inhibited; after detachment of the agglutinin, there is a delayed increase in rate of lysis to values above normal.
J B, BATEMAN, M S, DAVIS, P A, MCCAFFREY
openaire   +2 more sources

Role of the transmembrane domain in severe acute respiratory syndrome (SARS) coronavirus 2 spike for palmitoylation and membrane fusion

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Palmitoylation is a reversible post‐translational modification that enhances protein hydrophobicity and regulates cellular functions such as trafficking and signaling. In humans, this modification is catalyzed by 23 DHHC enzymes, but the mechanisms by which they recognize their substrates remain unclear.
Dina A. Abdulrahman, Michael Veit
wiley   +1 more source

Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance

Journal of Clinical Investigation, 2018
Hemagglutination inhibition (HI) titers are a major correlate of protection for influenza-related illness. The influenza virus hemagglutinin possesses antigenic sites that are the targets of HI active antibodies.
Sean T. H. Liu, M. A. Behzadi, Weina Sun, Alec W. Freyn, Wen-Chun Liu, F. Broecker, R. Albrecht, Nicole M. Bouvier, V. Simon, Raffael Nachbagauer, F. Krammer, P. Palese   +11 more
semanticscholar   +1 more source

Occurrence of Circulating Antibodies against the Hemagglutinins of Influenza Viruses in the 2022/2023 Epidemic Season in Poland

Viruses
The aim of this study was to determine the level of anti-hemagglutinin antibodies in blood sera collected from patients during the 2022/2023 epidemic season in Poland. A total of 700 sera samples from patients across the country were tested.
Katarzyna Kondratiuk, Anna Poznańska, Karol Szymański, Emilia Czajkowska, Bartosz Mańkowski, Lidia B. Brydak   +5 more
doaj   +1 more source

Differential Recognition of Computationally Optimized H3 Hemagglutinin Influenza Vaccine Candidates by Human Antibodies. [PDF]

J Virol, 2022
Abbadi N, Nagashima K, Pena-Briseno A, Ross TM, Mousa JJ.   +4 more
europepmc   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

Hemagglutinin Stalk-Reactive Antibodies Interfere with Influenza Virus Neuraminidase Activity by Steric Hindrance

Journal of Virology, 2018
This study reports a new mechanism of protection mediated by influenza hemagglutinin stalk-reactive antibodies, i.e., inhibition of neuraminidase activity by steric hindrance, blocking access of neuraminidase to sialic acids when it abuts hemagglutinin ...
Yao-qing Chen, L. Lan, Min Huang, Carole J Henry, P. Wilson   +4 more
semanticscholar   +1 more source