Results 151 to 160 of about 311,423 (321)

Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin

Cell Reports, 2019
Summary: Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. Molecular analysis of hemagglutinin (HA),
Ying Xu, Ruchao Peng, Wei Zhang, Jianxun Qi, Hao Song, Sheng Liu, Haiyuan Wang, Min Wang, Haixia Xiao, Lifeng Fu, Zheng Fan, Yuhai Bi, Jinghua Yan, Yi Shi, George F. Gao   +14 more
doaj   +1 more source

Chimeric hemagglutinin split vaccines elicit broadly cross-reactive antibodies and protection against group 2 influenza viruses in mice

, 2023
Eduard Puente‐Massaguer, Kirill Vasilev, A. Beyer, Madhumathi Loganathan, Benjamin Francis, Michael J. Scherm, Guha Asthagiri Arunkumar, Irene González‐Domínguez, Xueyong Zhu, Ian A. Wilson, Lynda Coughlan, Weina Sun, Peter Palese, Florian Krammer   +13 more
openalex   +1 more source

Timing of palmitoylation of influenza virus hemagglutinin

FEBS Letters, 1993
The timing of the attachment of fatty acids to the hemagglutinin (HA) of influenza A virus was studied. Treatment of virus infected cells with brefeldin A (BFA), a drug which blocks intracellular transport along the exocytic pathway at a pre‐Golgi site, does not prevent palmitoylation of HA.
Veit, Michael, Schmidt, Michael F.G.
openaire   +2 more sources

Emergence, spread, and impact of high‐pathogenicity avian influenza H5 in wild birds and mammals of South America and Antarctica

Conservation Biology, Volume 40, Issue 1, February 2026.
Abstract The currently circulating high‐pathogenicity avian influenza (HPAI) virus of the subtype H5 causes variable illness and death in wild and domestic birds and mammals, as well as in humans. This virus evolved from the Goose/Guangdong lineage of the HPAI H5 virus, which emerged in commercial poultry in China in 1996, spilled over into wild birds,
Thijs Kuiken, Ralph Eric Thijl Vanstreels, Ashley Banyard, Lineke Begeman, Andrew C. Breed, Meagan Dewar, Ruben Fijn, Patricia Pereira Serafini, Marcela Uhart, Michelle Wille   +9 more
wiley   +1 more source

Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Antigenic variation requires frequent revision of annual influenza vaccines. Next-generation vaccine design strategies aim to elicit a broader immunity by directing the human immune response toward conserved sites on the principal viral ...
D. Raymond, G. Bajic, J. Ferdman, Pirada Suphaphiphat, E. Settembre, M. A. Moody, A. Schmidt, S. Harrison, S. Harrison   +8 more
semanticscholar   +1 more source

Biosynthesis, structure, and biological activities of envelope protein gp65 of murine coronavirus. [PDF]

, 1989
We have previously shown that gp65 (E3) is a virion structural protein which varies widely in quantity among different strains of mouse hepatitis virus (MHV). In this study, the biosynthetic pathway and possible biological activities of this protein were
La Monica, N, Lai, MM, Makino, S, Shieh, CK, Yokomori, K   +4 more
core  

LAG‐3+ Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells

Immunology, Volume 177, Issue 2, Page 317-328, February 2026.
LAG‐3+ regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen‐specific CD4+ T cells in vivo. The suppressed T cells display upregulation of immune checkpoints and downregulation of pro‐inflammatory pathways with enhanced TCR signaling and reduced oxidative metabolism.
Avijit Dutta, Shi‐Chuen Miaw, Tse‐Ching Chen, Chia‐Shiang Chang, Yu‐Lin Huang, Yung‐Chang Lin, Chun‐Yen Lin, Ching‐Tai Huang   +7 more
wiley   +1 more source

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

International Journal of Molecular Sciences, 2017
The hemagglutinin (HA) and neuraminidase (NA) glycoproteins of influenza A virus are responsible for the surface interactions of the virion with the host.
Lauren Byrd-Leotis, R. Cummings, D. Steinhauer   +2 more
semanticscholar   +1 more source

Production of the recombinant hemagglutinin protein of the swine influenza virus A/H1N1 and analysis of its physicochemical and antigenic properties

Тонкие химические технологии
Objectives. To analyze the physicochemical and antigenic properties of recombinant hemagglutinin protein of swine influenza virus strain A/H1N1 (swH1-His) obtained by transduction of suspension line HEK293 with recombinant human adenovirus serotype 5 ...
E. D. Avdonina, K. A. Pervoykina, L. V. Verkhovskaya, D. N. Shcherbinin, N. Yu. Viskova, I. S. Kruzhkova, M. A. Ilina, L. V. Kudriavtseva, L. V. Kolobukhina, M. M. Shmarov, N. A. Antipyat, A. L. Gintsburg, I. N. Tyurin   +12 more
doaj   +1 more source

Computational design of trimeric influenza neutralizing proteins targeting the hemagglutinin receptor binding site

Nature Biotechnology, 2017
Many viral surface glycoproteins and cell surface receptors are homo-oligomers, and thus can potentially be targeted by geometrically matched homo-oligomers that engage all subunits simultaneously to attain high avidity and/or lock subunits together. The
Eva-Maria Strauch, S. Bernard, David La, A. Bohn, Peter S. Lee, Caitlin E. Anderson, Travis Nieusma, C. Holstein, N. Garcia, K. Hooper, Rashmi Ravichandran, Jorgen W. Nelson, W. Sheffler, J. Bloom, Kelly K. Lee, A. Ward, P. Yager, D. Fuller, I. Wilson, D. Baker   +19 more
semanticscholar   +1 more source