Results 11 to 20 of about 311,423 (321)

Influenza Hemagglutinin Structures and Antibody Recognition [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
Hemagglutinin (HA) is most abundant glycoprotein on the influenza virus surface. Influenza HA promotes viral entry by engaging the receptor and mediating virus-host membrane fusion. At the same time, HA is the major antigen of the influenza virus. HA antigenic shift can result in pandemics, whereas antigenic drift allows human circulating strains to ...
Nicholas C, Wu, Ian A, Wilson
openaire   +3 more sources

Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral Hemagglutinin

Viruses, 2019
Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial and immunomodulatory activities.
Fabiana Superti, Mariangela Agamennone, Agostina Pietrantoni, Maria Grazia Ammendolia   +3 more
doaj   +2 more sources

Structural and antigenic characterization of a computationally-optimized H5 hemagglutinin influenza vaccine. [PDF]

Vaccine, 2019
Bar-Peled Y, Huang J, Nuñez IA, Pierce SR, Ecker JW, Ross TM, Mousa JJ.   +6 more
europepmc   +2 more sources

Self-Assembling Nanoparticle Hemagglutinin Influenza Vaccines Induce High Antibody Response. [PDF]

Int J Mol Sci
As a highly pathogenic avian virus, H5 influenza poses a serious threat to livestock, the poultry industry, and public health security. Hemagglutinin (HA) is both the dominant epitope and the main target of influenza-neutralizing antibodies.
Ren H, Zhang B, Zhang X, Wang T, Hou X, Lan X, Pan C, Wu J, Liu B.   +8 more
europepmc   +2 more sources

Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses

Emerging Microbes and Infections, 2023
Avian influenza viruses (AIV) have been classified on the basis of 16 subtypes of hemagglutinin (HA) and 9 subtypes of neuraminidase. Here we describe genomic evidence for a new candidate HA subtype, nominally H19, with a large genetic distance to all ...
S. Fereidouni, E. Starick, K. Karamendin, C. Genova, S. Scott, Y. Khan, T. Harder, A. Kydyrmanov   +7 more
semanticscholar   +1 more source

An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults

Science Translational Medicine, 2023
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive neutralizing stem-directed antibodies.
A. Widge, A. Hofstetter, Katherine V. Houser, S. Awan, Grace L. Chen, Maria C. Burgos Florez, N. Berkowitz, Floreliz H. Mendoza, C. S. Hendel, L. Holman, Ingelise J. Gordon, Preeti Apte, C. Liang, M. Gaudinski, Emily E. Coates, L. Strom, Diane L Wycuff, Sandra Vazquez, Judy A. Stein, J. Gall, W. Adams, Kevin Carlton, Rebecca A. Gillespie, A. Creanga, M. Crank, Sarah F. Andrews, Mike Castro, L. Serebryannyy, S. Narpala, C. Hatcher, Bob C. Lin, S. O'connell, Alec W. Freyn, Victoria C. Rosado, Raffael Nachbagauer, P. Palese, M. Kanekiyo, A. McDermott, R. Koup, L. Dropulic, B. Graham, J. Mascola, J. Ledgerwood, Allison Beck, J. Casazza, Christopher L. Case, J. Misasi, Abidemi O. Ola, K. Parker, Richard L Wu, Pamela J M Costner, J. Saunders, L. Novik, W. Whalen, Xiaolin Wang, A. Eshun, Jennifer Cunningham, A. Arthur, Morgan A. Anderson, Justine Jones, B. Larkin, Thuy A. Nguyen, S. Sitar, L. Le, Iris Pittman, O. Vasilenko, G. Yamshchikov, R. S. Rothwell, Eugenia Burch, Olga Trofymenko, Sarah H. Plummer, Catina Evans, C. T. Cartagena, Renunda Hicks, LaShawn Requilman, Pernell Williams, Carmen M. Graves, Shinyi Telscher, G. Albright, Jessica Bahorich, Sashikanth Banappagari, Michael F. Bender, Alegria T. Caringal, Juliane Carvalho, Rajoshi Chaudhuri, Mythili Chintamani, J. Cooper, Jacob Demirji, T. Dinh, G. Dobrescu, Alvenne Goh, Deepika Gollapudi, Raju Gottumukkala, Daniel B. Gowetski, J. Holland-Linn, Jin Sung Hong, J. Horwitz, Vera B. Ivleva, L. Kueltzo, Nadji Lambert, Alaina J LaPanse, Heather A. Lawlor, Kristin M. Leach, James Lee, P. Lei, Yile Li, Jie Liu, Slobodanka D. Manceva, Aakash Patel, Rahul Ragunathan, Lori Romaine, Erwin Rosales, Nikki Schneck, W. Shadrick, Andrew Shaddeau, Sudesh Upadhyay, K. Vickery, Xiangchun E. Wang, Xin Wang, Jack X. Yang, R. Yang, Yanhong Yang, Ya-Sha Yi, W. Zhao, Zhong Zhao   +124 more
semanticscholar   +1 more source

Strategies Targeting Hemagglutinin as a Universal Influenza Vaccine

Vaccines, 2021
Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza ...
Brianna L. Bullard, E. Weaver
semanticscholar   +1 more source

Prolonged Codelivery of Hemagglutinin and a TLR7/8 Agonist in a Supramolecular Polymer–Nanoparticle Hydrogel Enhances Potency and Breadth of Influenza Vaccination

ACS Biomaterials Science & Engineering, 2021
The sustained release of vaccine cargo has been shown to improve humoral immune responses to challenging pathogens such as influenza. Extended codelivery of antigen and adjuvant prolongs germinal center reactions, thus improving antibody affinity ...
Gillie A. Roth, Olivia Saouaf, Anton A. A. Smith, Emily C. Gale, Marcela Hernandez, J. Idoyaga, Eric A. Appel   +6 more
semanticscholar   +1 more source

Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. [PDF]

PLoS ONE, 2013
Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the initial steps of viral infection through receptor binding and membrane fusion events.
Alicia Jiménez-Alberto, Esmeralda Alvarado-Facundo, Rosa María Ribas-Aparicio, Juan A Castelán-Vega   +3 more
doaj   +1 more source

Antivirals Targeting the Surface Glycoproteins of Influenza Virus: Mechanisms of Action and Resistance

Viruses, 2021
Hemagglutinin and neuraminidase, which constitute the glycoprotein spikes expressed on the surface of influenza A and B viruses, are the most exposed parts of the virus and play critical roles in the viral lifecycle.
Yaqin Bai, Jeremy C. Jones, Sook-San Wong, Mark Zanin   +3 more
doaj   +1 more source