Results 281 to 290 of about 311,423 (321)

An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans

Science Translational Medicine, 2023
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region.
Sarah F. Andrews, Lauren Y Cominsky, Geoffrey D. Shimberg, Rebecca A. Gillespie, J. Gorman, J. Raab, Joshua Brand, A. Creanga, Supra R. Gajjala, S. Narpala, C. S. Cheung, Darcy R. Harris, T. Zhou, Ingelise J. Gordon, L. Holman, Floreliz H. Mendoza, Katherine V. Houser, Grace L. Chen, J. Mascola, B. Graham, P. Kwong, A. Widge, L. Dropulic, J. Ledgerwood, M. Kanekiyo, A. McDermott   +25 more
semanticscholar   +1 more source

Influenza virus neuraminidase with hemagglutinin activity

Virology, 1984
Isolated intact influenza virus neuraminidase (NA) molecules of the N9 subtype have been found to possess hemagglutinin (HA) activity which, at equivalent protein concentration, was fourfold higher than that of isolated hemagglutinin molecules of the H3 subtype.
W G, Laver, P M, Colman, R G, Webster, V S, Hinshaw, G M, Air   +4 more
openaire   +2 more sources

Inhibitors Targeting the Influenza Virus Hemagglutinin

Current Medicinal Chemistry, 2015
The annual flu season causes thousands of deaths and millions of hospitalizations, which pose a great burden to global health and economy. Moreover, a flu pandemic arising from reassortment viruses, such as H5N1 and H1N1, raises even greater concern due to the lack of effective vaccines at the initial stage of flu outbreak.
F, Li, C, Ma, J, Wang
openaire   +2 more sources

Investigational hemagglutinin-targeted influenza virus inhibitors

Expert Opinion on Investigational Drugs, 2016
Seasonal influenza and pandemic outbreaks typically result in high mortality and morbidity associated with severe economic burdens. Vaccines and anti-influenza drugs have made great contributions to control the infection. However, antigenic drifts and shifts allow influenza viruses to easily escape immune neutralization and antiviral drug activity ...
Li-Yan, Zeng, Jie, Yang, Shuwen, Liu
openaire   +2 more sources

Cryocrystallography of influenza virus hemagglutinin crystals

Acta Crystallographica Section D Biological Crystallography, 1995
X-ray diffraction data collected at cryogenic temperatures from flash-cooled crystals of influenza virus hemagglutinin show improvements in both resolution and quality relative to data collected at 277 K. These improvements are dramatic for flash-cooled hemagglutinin crystals irradiated with X-rays from a synchrotron source.
S J, Watowich, J J, Skehel, D C, Wiley
openaire   +2 more sources

Fighting influenza through hemagglutinin diversity

Nature Immunology, 2019
A multivalent vaccine that presents diverse influenza virus subtype H1 hemagglutinins on its surface induces broadly neutralizing antibodies in an animal model by displaying conserved epitopes at higher density than strain-specific epitopes.
openaire   +2 more sources

Structure of the Influenza Virus Hemagglutinin

1981
Influenza has plagued man for centuries and has been described as an unvarying disease caused by a varying virus (Kilbourne 1975). It frequently affects a large proportion of the population irrespective of age or previous infection history and remains today a poorly controlled disease, despite the fact that the infectious agent, influenza virus, was ...
openaire   +2 more sources

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

Nature Medicine, 2015
The antibody response to influenza is primarily focused on the head region of the hemagglutinin (HA) glycoprotein, which in turn undergoes antigenic drift, thus necessitating annual updates of influenza vaccines. In contrast, the immunogenically subdominant stem region of HA is highly conserved and recognized by antibodies capable of binding multiple ...
Hadi M Yassine, Jeffrey C Boyington, Patrick M McTamney, Chih-Jen Wei, Masaru Kanekiyo, Wing-Pui Kong, John R Gallagher, Lingshu Wang, Yi Zhang, M Gordon Joyce, Daniel Lingwood, Syed M Moin, Hanne Andersen, Yoshinobu Okuno, Srinivas S Rao, Audray K Harris, Peter D Kwong, John R Mascola, Gary J Nabel, Barney S Graham   +19 more
openaire   +2 more sources