Results 31 to 40 of about 311,423 (321)

Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome

mBio, 2022
Individuals with metabolic dysregulation of cellular glycosylation often experience severe influenza disease, with a poor immune response to the virus and low vaccine efficacy.
Irina V. Alymova, John F. Cipollo, Lisa M. Parsons, Nedzad Music, Ram P. Kamal, Wen-Pin Tzeng, Cynthia S. Goldsmith, Joseph N. Contessa, Kevan L. Hartshorn, Jason R. Wilson, Hui Zeng, Shane Gansebom, Ian A. York   +12 more
doaj   +1 more source

Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine [PDF]

, 2014
Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine ...
A. L. Vincent, Anderson, Bao, Bowman, Brown, Centers for Disease Control and Prevention, Core Team R, D. F. Burke, Darriba, De Jong, E. Skepner, Edgar, Feng, Fouchier, Garten, Gauger, Harmon, Hinshaw, Houser, Karasin, Kawaoka, Khurana, Kitikoon, Koel, Lewis, Lindstrom, Lorusso, Loving, Maddison, Miller, Montalvao, Myers, N. S. Lewis, Nelson, Nelson, Nfon, Olsen, P. Kitikoon, Paradis, Pena, Polewicz, PyMOL, Röhm, Salmon, Shinde, Skowronski, Smith, Smith, Stamatakis, T. K. Anderson, Tong, Tong, Vincent, Vincent, Vincent, Vincent, Webby, Webby, Ye   +58 more
core   +2 more sources

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations.

PLoS ONE, 2018
The standard method to quantify the hemagglutinin content of influenza virus vaccines is the single radial immunodiffusion assay. This assay primarily relies on polyclonal antibodies against the head domain of the influenza virus hemagglutinin, which is ...
Madhusudan Rajendran, Weina Sun, Phillip Comella, Raffael Nachbagauer, Teddy John Wohlbold, Fatima Amanat, Ericka Kirkpatrick, Peter Palese, Florian Krammer   +8 more
doaj   +1 more source

Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus.

PLoS ONE, 2016
Significant genetic variability in the head region of the influenza A hemagglutinin, the main target of current vaccines, makes it challenging to develop a long-lived seasonal influenza prophylaxis.
Miriam Klausberger, Rupert Tscheliessnig, Silke Neff, Raffael Nachbagauer, Teddy John Wohlbold, Monika Wilde, Dieter Palmberger, Florian Krammer, Alois Jungbauer, Reingard Grabherr   +9 more
doaj   +1 more source

Influenza hemagglutinin drives viral entry via two sequential intramembrane mechanisms

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Viral proteins that accomplish membrane fusion between the virus and a host cell do two things: draw virus and host membranes together and act within these membranes to induce fusion.
A. Pabis, R. J. Rawle, P. Kasson
semanticscholar   +1 more source

Large-scale sequence analysis of hemagglutinin of influenza A virus identifies conserved regions suitable for targeting an anti-viral response. [PDF]

PLoS ONE, 2010
BACKGROUND: Influenza A viral surface protein, hemagglutinin, is the major target of neutralizing antibody response and hence a main constituent of all vaccine formulations. But due to its marked evolutionary variability, vaccines have to be reformulated
Leepakshi Sahini, Anna Tempczyk-Russell, Ritu Agarwal   +2 more
doaj   +1 more source

Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]

, 2015
Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael, Ferrara, Francesca, Flynn, Jessica A, Liang, Xiaoping, Mallajosyula, Vamsee V A, Temperton, Nigel J., Varadarajan, Raghavan   +6 more
core   +4 more sources

Inferring stabilizing mutations from protein phylogenies : application to influenza hemagglutinin [PDF]

, 2009
One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions.
A Akasako, A Akasako, A Cao, A Martin, A Mitraki, A Rambaut, AA Pakula, AR Dinner, AR Fersht, AR Fersht, AS Yang, AS Yang, AV Gribenko, B Steipe, B Steipe, BM Broome, C Pal, C Park, CB Anfinsen, CB Do, CM Dobson, CT Saunders, D Gilis, D Perl, D Shortle, DA Cowan, DA Drummond, DA Drummond, DD Loeb, DM Taverna, DM Taverna, E Capriotti, E Hoffmann, E van Nimwegen, EPC Rocha, Eugene I. Shakhnovich, F Chiti, F Ronquist, G Parisi, GG Brownlee, H Akashi, H Li, H Schindelin, H Zhao, H Zhou, HW Hellinga, I Keller, IE Sanchez, IMP del Pino, J Felsenstein, J Felsenstein, J Felsenstein, J Felsenstein, J Kyte, JA Wells, JB Garrett, JD Bloom, JD Bloom, JD Bloom, JD Bloom, Jesse D. Bloom, JL Thorne, JM Koshi, JP Huelsenbeck, JP Huelsenbeck, JR Cochran, JR Lepock, JV Chamary, K Ishikawa, K Ishikawa, K Katayanagi, KA Bava, KA Gray, KB Zeldovich, KJ Szretter, KL Maxwell, L Giver, L Serrano, M Dai, M Haruki, M Jacob, M Lehmann, M Matrosovich, M Ueda, M Wunderlich, Matthew J. Glassman, MD Kumar, MF Sippl, MM Garcia-Mira, MM Gromiha, MP Canadillas, MS Fornasari, MW Pantoliano, N Amin, N Goldman, N Goldman, N Lartillot, N Tong, R Godoy-Ruiz, R Godoy-Ruiz, R Godoy-Ruiz, R Guerois, R Rabadan, R Sakaue, RC Edgar, RJ Ellis, S Govindarajan, S Kimura, S Kimura, S Nakajima, S Sato, SC Choi, SH White, SJ Gamblin, SS Jaswal, U Bastolla, V Parthiban, VG Dugan, VN Uversky, W Besenmatter, WS Sandberg, WSW Wong, XJ Zhang, Y Bao, YY Tseng, Z Chen   +125 more
core   +3 more sources

A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies

Vaccines, 2018
The antigenically conserved hemagglutinin stalk region is a target for universal influenza virus vaccines since antibodies against it can provide broad protection against influenza viruses of different subtypes.
Sun-Young Sunwoo, Michael Schotsaert, Igor Morozov, Anne Sally Davis, Yuhao Li, Jinhwa Lee, Chester McDowell, Philip Meade, Raffael Nachbagauer, Adolfo García-Sastre, Wenjun Ma, Florian Krammer, Juergen A. Richt   +12 more
doaj   +1 more source

Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]

, 1997
Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew, Dimmock, N. J., Taylor, H. P.   +2 more
core   +2 more sources