Results 51 to 60 of about 311,423 (321)

Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus

Vaccines
In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets ...
Nadezhda B. Rudometova, Anastasia A. Fando, Lyubov A. Kisakova, Denis N. Kisakov, Mariya B. Borgoyakova, Victoria R. Litvinova, Vladimir A. Yakovlev, Elena V. Tigeeva, Danil I. Vahitov, Sergey V. Sharabrin, Dmitriy N. Shcherbakov, Veronika I. Evseenko, Ksenia I. Ivanova, Andrei S. Gudymo, Tatiana N. Ilyicheva, Vasiliy Yu. Marchenko, Alexander A. Ilyichev, Andrey P. Rudometov, Larisa I. Karpenko   +18 more
doaj   +1 more source

Genetic Evolution and Molecular Selection of the HE Gene of Influenza C Virus [PDF]

, 2019
Influenza C virus (ICV) was first identified in humans and swine, but recently also in cattle, indicating a wider host range and potential threat to both the livestock industry and public health than was originally anticipated.
He, Wanting, Li, Gairu, Su, Shuo, Veit, Michael, Wang, Congcong, Wen, Baiqing, Xu, Qiuhua, Zhang, Letian, Zhang, Wenyan, Zhang, Xu, Zhou, Jiyong   +10 more
core   +1 more source

Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus : studies in the pig model of influenza [PDF]

, 2015
Pigs are natural hosts for the same influenza virus subtypes as humans and are a valuable model for cross-protection studies with influenza. In this study, we have used the pig model to examine the extent of virological protection between a) the 2009 ...
A Krumbholz, A Lavenu, AC Lowen, AI Karasin, AR Vleeschauwer De, AS Monto, B Brandenburg, B Manicassamy, B Srivastava, CD O’Donnell, CD O’Donnell, CS Kyriakis, CS Kyriakis, DM Skowronski, ED Kilbourne, G Simon, GA Landolt, GG Brownlee, I Skountzou, IH Brown, JC Kash, JH Kreijtz, JL Schulman, K Hoschler, K Reeth Van, K Reeth Van, K Reeth Van, K Reeth Van, K Tamura, Karl De hert, KL Laurie, Kristien Van Reeth, L Campitelli, M Khatri, M Pensaert, M Retamal, M Strengell, MA Marco De, MI Nelson, MJ Sylte, ML Hillaire, MR Castrucci, MR Castrucci, MR Sandbulte, N Busquets, NM Bouvier, PM Colman, PP Heinen, RA Perera, RA Yetter, RJ Garten, S Liang, SL Epstein, SM Brookes, T Sonoguchi, TM Straight, Y Qiu, Y Qiu, Yu Qiu   +58 more
core   +6 more sources

Mechanisms of Hemagglutinin Targeted Influenza Virus Neutralization

PLoS ONE, 2013
Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved hemagglutinin (HA) epitopes of broadly neutralizing antibodies to critical processes in the viral life ...
Brandenburg, Boerries, Koudstaal, Wouter, Goudsmit, Jaap, Klaren, Vincent, Tang, Chan, Bujny, Miriam V., Korse, Hans J. W. M., Kwaks, Ted, Otterstrom, Jason J., Juraszek, Jarek, van Oijen, Antoine M., Vogels, Ronald, Friesen, Robert H. E.   +12 more
openaire   +6 more sources

Influenza research database: an integrated bioinformatics resource for influenza research and surveillance. [PDF]

, 2012
BackgroundThe recent emergence of the 2009 pandemic influenza A/H1N1 virus has highlighted the value of free and open access to influenza virus genome sequence data integrated with information about other important virus characteristics.DesignThe ...
Baumgarth, Nicole, Deitrich, Jon, García-Sastre, Adolfo, Hunt, Victoria, Klem, Edward, Kumar, Sanjeev, Larsen, Christopher N, Macken, Catherine, Noronha, Jyothi, Pickett, Brett E, Ramsey, Alvin, Scheuermann, Richard H, Squires, R Burke, Suarez, David, Zaremba, Sam, Zhang, Yun, Zhou, Liwei   +16 more
core   +1 more source

Universal Influenza Virus Vaccines That Target the Conserved Hemagglutinin Stalk and Conserved Sites in the Head Domain.

Journal of Infectious Diseases, 2019
Due to limitations of current influenza virus vaccines, new vaccines that mediate broad protection and show high efficacy against seasonal and pandemic viruses are urgently needed.
F. Krammer, P. Palese
semanticscholar   +1 more source

Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK [PDF]

, 1995
The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were
A. J. Easton, Cane, Colman, Elango, K. R. Collins, Sambrook, van Wyke Coelingh   +6 more
core   +2 more sources

Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine Immunogens.

Journal of Infectious Diseases, 2019
Influenza viruses routinely acquire mutations in their hemagglutinin (HA) and neuraminidase (NA) glycoproteins that abrogate binding of pre-existing antibodies in a process known as antigenic drift.
Seth J. Zost, N. Wu, S. Hensley, I. Wilson   +3 more
semanticscholar   +1 more source

Mallards and Highly Pathogenic Avian Influenza Ancestral Viruses, Northern Europe

Emerging Infectious Diseases, 2005
Outbreaks of highly pathogenic avian influenza (HPAI), which originate in poultry upon transmission of low pathogenic viruses from wild birds, have occurred relatively frequently in the last decade.
Vincent J. Munster, Anders Wallensten, Chantal Baas, Guus F. Rimmelzwaan, Martin Schutten, Björn Olsen, Albert D.M.E. Osterhaus, Ron A.M. Fouchier   +7 more
doaj   +1 more source

Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]

, 2018
Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
core   +2 more sources