Results 71 to 80 of about 311,423 (321)

Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice

Journal of Virology, 2019
While broadly protective antibodies against the influenza A virus hemagglutinin have been well studied, very limited information is available for antibodies that broadly recognize influenza B viruses.
Guha Asthagiri Arunkumar, Andriani Ioannou, Teddy J. Wohlbold, Philip Meade, S. Aslam, F. Amanat, Juan Ayllon, A. García-Sastre, F. Krammer   +8 more
semanticscholar   +1 more source

A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin—A Picture of an Avian Virus on the Verge of Becoming a Pandemic?

Vaccines, 2017
Pandemic influenza is a constant global threat to human health. In particular, the pandemic potential of novel avian influenza viruses such as the H10N7 and H10N8 avian strains, which recently managed to cross the species barrier from birds to humans ...
Elena K. Schneider, Jian Li, Tony Velkov
doaj   +1 more source

Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes [PDF]

, 1980
Two populations of cytolytic T lymphocytes (CTL) generated after influenza A virus infection can be distinguished into one with specificity for the sensitizing hemagglutinin type and a second with cross-reactivity for antigens induced by other type-A ...
Allen, H., Gething, M. J., Klenk, H. D., Koszinowski, Ulrich H., Waterfield, M. D.   +4 more
core   +2 more sources

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach

Journal of Virology, 2019
This work reports a universal influenza B virus vaccination strategy based on focusing antibody responses to conserved head and stalk epitopes of the hemagglutinin.
Weina Sun, Ericka Kirkpatrick, Megan E. Ermler, Raffael Nachbagauer, F. Broecker, F. Krammer, P. Palese   +6 more
semanticscholar   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

bioRxiv, 2019
A longstanding question is how influenza evolves to escape human immunity, which is polyclonal and can target many distinct epitopes on the virus. Here we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization ...
Juhye M. Lee, Rachel T. Eguia, Seth J. Zost, S. Choudhary, P. Wilson, T. Bedford, T. Stevens-Ayers, M. Boeckh, A. Hurt, S. Lakdawala, S. Hensley, J. Bloom   +11 more
semanticscholar   +1 more source

The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus

Cell Reports, 2017
Summary: Adaptation of influenza A viruses to new hosts are rare events but are the basis for emergence of new influenza pandemics in the human population.
Netanel Tzarum, Robert P. de Vries, Wenjie Peng, Andrew J. Thompson, Kim M. Bouwman, Ryan McBride, Wenli Yu, Xueyong Zhu, Monique H. Verheije, James C. Paulson, Ian A. Wilson   +10 more
doaj   +1 more source

Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile

Emerging Infectious Diseases, 2020
Since their discovery in the United States in 1963, outbreaks of infection with equine influenza virus (H3N8) have been associated with serious respiratory disease in horses worldwide.
Nicolas Bravo-Vasquez, Jiangwei Yao, Pedro Jimenez-Bluhm, Victoria Meliopoulos, Pamela Freiden, Bridgett Sharp, Leonardo Estrada, Amy Davis, Sean Cherry, Brandi Livingston, Angela Danner, Stacey Schultz-Cherry, Christopher Hamilton-West   +12 more
doaj   +1 more source

Effect of [6]-gingerol on viral neuraminidase and hemagglutinin-specific T cell immunity in severe influenza

Phytomedicine Plus, 2023
Background: H1N1 influenza viruses are the leading cause of severe respiratory virus infections worldwide. Resistance to the current selections of anti-influenza agents are still of concern.
Avijit Dutta, Sung-Han Hsiao, Chen-Yiu Hung, Chia-Shiang Chang, Yung-Chang Lin, Chun-Yen Lin, Tse-Ching Chen, Ching-Tai Huang   +7 more
doaj   +1 more source