Results 81 to 90 of about 311,423 (321)

A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine [PDF]

, 2017
Avian H9N2 and 2009 pandemic H1N1 (pH1N1) influenza viruses can infect pigs and humans, raising the concern that H9N2: pH1N1 reassortant viruses could emerge.
Ma, Wenjun, Mancera Gracia, José Carlos, Richt, Juergen A, Saelens, Xavier, Van den Hoecke, Silvie, Van Reeth, Kristien   +5 more
core   +2 more sources

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

A mosaic hemagglutinin-based influenza virus vaccine candidate protects mice from challenge with divergent H3N2 strains

npj Vaccines, 2019
Current seasonal influenza virus vaccines only provide limited, short-lived protection, and antigenic drift in the hemagglutinin surface glycoprotein necessitates their annual re-formulation and re-administration. To overcome these limitations, universal
F. Broecker, Sean T. H. Liu, N. Suntronwong, Weina Sun, M. Bailey, Raffael Nachbagauer, F. Krammer, P. Palese   +7 more
semanticscholar   +1 more source

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Nature Communications
Influenza B viruses are antigenically diverse and contribute significantly to the annual influenza burden. Here we report influenza B virus neutralizing single-domain antibodies that target highly conserved regions of the hemagglutinin and neuraminidase.
Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N. Savvides, Xavier Saelens   +9 more
doaj   +1 more source

The Potential of Influenza HA-Specific Immunity in Mitigating Lethality of Postinfluenza Pneumococcal Infections

Vaccines, 2019
: Influenza virus infections pre-dispose an individual to secondary pneumococcal infections, which represent a serious public health concern. Matching influenza vaccination was demonstrated helpful in preventing postinfluenza bacterial infections and ...
Miriam Klausberger, Irina A. Leneva, Irina N. Falynskova, Kirill Vasiliev, Alexander V. Poddubikov, Claudia Lindner, Nadezhda P. Kartaschova, Oxana A. Svitich, Marina Stukova, Reingard Grabherr, Andrej Egorov   +10 more
doaj   +1 more source

Generation of a DSF-Guided Refolded Bacterially Expressed Hemagglutinin Ectodomain of Influenza Virus A/Puerto Rico/8/1934 H1N1 as a Model for Influenza Vaccine Antigens

Vaccines, 2023
Influenza virus infections represent an ongoing public health threat as well as an economic burden. Although seasonal influenza vaccines have been available for some decades, efforts are being made to generate new efficient, flexible, and cost-effective ...
Vlad-Constantin Tofan, Andreea-Laura Ermeneanu, Iuliana Caraș, Alina Lenghel, Irina-Elena Ionescu, Cătălin Țucureanu, Claudiu Gal, Crina-Georgeta Stăvaru, Adrian Onu   +8 more
doaj   +1 more source

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. [PDF]

, 2018
Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world.
Alain Gagnon, D. Ann Herring, David J. D. Earn, Enrique Acosta, Joaquin Madrenas, Kris Inwood, Lisa Y. Dillon, Matthew S. Miller, Nadine Ouellette, Robert Bourbeau, Stacey Hallman, W. Ian Lipkin   +11 more
core   +3 more sources

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies

Scientific Reports, 2019
Epitope-focused approaches for selective clonal induction of broadly neutralizing antibodies (bnAbs) inform most current vaccine strategies for influenza virus and other rapidly evolving pathogens.
G. Bajic, C. E. van der Poel, M. Kuraoka, A. Schmidt, M. Carroll, G. Kelsoe, S. Harrison   +6 more
semanticscholar   +1 more source

Cell-Based Manufacturing Technology Increases Antigenic Match of Influenza Vaccine and Results in Improved Effectiveness

Vaccines, 2022
To ensure that vaccination offers the best protection against an infectious disease, sequence identity between the vaccine and the circulating strain is paramount.
Steven Rockman, Karen Laurie, Chi Ong, Sankarasubramanian Rajaram, Ian McGovern, Vy Tran, John Youhanna   +6 more
doaj   +1 more source