Results 121 to 130 of about 39,654 (286)

Random Mutagenesis in Porphyromonas gingivalis Enables Isolation of Mutants With Enhanced Secreted Protease Activity

Molecular Oral Microbiology, Volume 41, Issue 3, Page 158-164, June 2026.
ABSTRACT Porphyromonas gingivalis is a key pathogen in periodontitis, with secreted proteases as major virulence factors. We developed a screening method to generate and identify P. gingivalis mutants with elevated protease activity. Mutations were induced using the mutagens 2,6‐diaminopurine (2,6‐DAP) or ethyl methanesulfonate (EMS), and the ...
Takeru Nakabayashi, Satoshi Yuhara, Kosei Tanaka   +2 more
wiley   +1 more source

Dependence of the energies of fusion on the intermembrane separation: optimal and constrained

, 2007
We calculate the characteristic energies of fusion between planar bilayers as afunction of the distance between them, measured from the hydrophobic/hydrophilic interface of one of the two nearest, cis, leaves to the other.
Lee, J. Y., Schick, M.
core   +1 more source

Hypoxic and Fe‐Responses are Regulated by the ERFVII Factors and the PCO Branch of the N‐Degron Pathway According to Iron Availability

Plant, Cell &Environment, Volume 49, Issue 6, Page 3363-3380, June 2026.
ABSTRACT In plants, iron homeostasis and oxygen metabolism are strictly related, indeed several Fe‐requiring enzymes catalyze reactions that also involve O2 as a reagent, product, entry or end point of the pathway. Oxygen sensing itself relies on the Fe‐dependent enzymes Plant cysteine oxidases.
Yuri Telara, Moez Maghrebi, Mikel Lavilla‐Puerta, Noemi La Monaca, Giulia Ambrogini, Alessio Sbrana, Sara Delucchi, Pierdomenico Perata, Gianpiero Vigani, Beatrice Giuntoli   +9 more
wiley   +1 more source

A Retrospective Cross‐Sectional Study (2009–2023): Exploring Influenza A(H1N1)pdm09 Antibody Time Series in Humans and Swine and Vaccine Coverage in Two Target Groups

Zoonoses and Public Health, Volume 73, Issue 4, Page 336-347, June 2026.
ABSTRACT Introduction Swine may act as ‘epidemiological bridges’ and reservoirs for the emergence of novel zoonotic influenza viruses with pandemic potential. While bidirectional exchange of influenza A viruses at the swine–human interface is well recognised, data on the extent of interspecies transmission are limited.
Solveig Jore, Ragnhild Tønnessen, Carl Andreas Grøntvedt, Kjersti Rydland, Anna Germundsson Hauge, Olav Hungnes, Anja Bråthen Kristoffersen, Even Fossum   +7 more
wiley   +1 more source

Stability of rubella hemagglutinin [PDF]

Applied Microbiology, 1968
R R, Rafajko, S, Polakavetz, B, Handelman, D, Zur Nedden   +3 more
openaire   +2 more sources

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, Volume 13, Issue 25, 4 May 2026.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, Volume 13, Issue 26, 8 May 2026.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

Immunogenicity of chimeric hemagglutinins delivered by an orf virus vector platform against swine influenza virus

Frontiers in Immunology
Orf virus (ORFV) is a large DNA virus that can harbor and efficiently deliver viral antigens in swine. Here we used ORFV as a vector platform to deliver chimeric hemagglutinins (HA) of Influenza A virus of swine (IAV-S). Vaccine development against IAV-S
Gabriela Mansano do Nascimento, Pablo Sebastian Britto de Oliveira, Pablo Sebastian Britto de Oliveira, Salman Latif Butt, Diego G. Diel   +4 more
doaj   +1 more source

A Genetic Reporter for Visualizing Nitroreductase Activity Using Magnetic Resonance Imaging

Chemistry–Methods, Volume 6, Issue 5, May 2026.
We introduce a reporter gene technology to noninvasively visualize bacterial nitroreductase activity. Our method utilizes a magnetic resonance imaging (MRI) reporter based on aquaporin, which is fused to a destabilizing domain, resulting in their degradation (off‐state).
Jinyang Wan, Asish N. Chacko, Emrys Xu, Kiran Kuriakose, Arnab Mukherjee   +4 more
wiley   +1 more source