Results 71 to 80 of about 39,654 (286)

Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR

Advanced Science, EarlyView.
The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz, Paola Oquist‐Phillips, Noelia de la Cruz, Inés Lera‐Lasso, Laura Castañar, Javier Rojo, Javier Ramos‐Soriano, Ángeles Canales   +7 more
wiley   +1 more source

Hemagglutinins and fimbriae of Providencia spp [PDF]

Journal of Bacteriology, 1981
A series of 25 strains of Providencia spp. produced at least five different patterns of hemagglutination as judged by results from hemagglutination tests in the presence and absence of D-mannose and at least six distinct types of fimbriae as seen from observations with the electron microscope.
D C, Old, S S, Scott
openaire   +2 more sources

Complete analysis of the H5 hemagglutinin and N8 neuraminidase phylogenetic trees reveals that the H5N8 subtype has been produced by multiple reassortment events [PDF]

, 2016
The analysis of the complete H5 hemagglutinin and H8 neuraminidase phylogenetic trees presented in this paper shows that the H5N8 avian influenza has been generated by multiple reassortment events.
A Dalby, A Dalby, A Dalby, A Rambaut, C Adlhoch, D Alexander, D Lee, F Matsen, G Smith, H Ip, H Shimodaira, H Wu, H Yoon, J Brown, J Jeong, J Pasick, J Verhagen, K Ku, K Tamura, M Jhung, M Price, R Squires, X Xu, Y Bao, Y Lee   +24 more
core   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it.

PLoS ONE, 2019
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across multiple
Wei Wang, Russell Vassell, Hyo Sook Song, Qiong Chen, Paul W Keller, Swati Verma, Esmeralda Alvarado-Facundo, Hongquan Wan, Falko Schmeisser, Clement A Meseda, Jerry P Weir, Carol D Weiss   +11 more
doaj   +1 more source

Hemagglutinins in Sera of Africans of Gambia

Experimental Biology and Medicine, 1968
SummaryThirty-eight sera from Africans of Gambia were studied serologically. Twenty-two sera had increased titers of agglutinins to guinea pig erythrocytes and 20 had increased titers of rat hemagglutinins. Of 19 individuals of blood group O, 9 had increased titers of agglutinins to human A and/or B erythrocytes.
K, Kano, I A, McGregor, F, Milgrom
openaire   +2 more sources

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Presence of a low molecular weight lectin in the coelomic fluid of the sea urchin Paracentrotus lividus [PDF]

Invertebrate Survival Journal, 2009
A low molecular weight (MW) lectin (Paracentrotus lividus small lectin, PlSL) has been found in the sea urchin, Paracentrotus lividus. After gel electrophoresis under denaturing conditions, PlSL exhibits a MW of 13 kDa, while its hemagglutinating ...
F Drago, D Malagoli, F M Pezzino, V D’Urso, F Sammartano   +4 more
doaj   +1 more source

Klebsiella variicola and Klebsiella quasipneumoniae with capacity to adapt to clinical and plant settings

Salud Pública de México, 2017
Objective. To compare the genetic determinants involved in plant colonization or virulence in the reported genomes of K. variicola, K. quasipneumoniae and K. pneumoniae. Materials and methods.
Esperanza Martínez-Romero, Nadia Rodríguez-Medina, Marilú Beltrán-Rojel, Jeiry Toribio-Jiménez, Ulises Garza-Ramos   +4 more
doaj   +1 more source

A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence [PDF]

, 2014
Although an effective interferon antagonist in human and avian cells, the novel H7N9 influenza virus NS1 protein is defective at inhibiting CPSF30. An I106M substitution in H7N9 NS1 can restore CPSF30 binding together with the ability to block host gene ...
Ayllon, Juan, Domingues, Patricia, Garcia-Sastre, Adolfo, Hale, Benjamin G., Miorin, Lisa, Rajsbaum, Ricardo, Schmolke, Mirco   +6 more
core   +3 more sources