Results 211 to 220 of about 2,243 (240)
Some of the next articles are maybe not open access.
Toxicology Letters, 1978
The toxicity of intravenously administered hematin (3.4 and 6 mg100 g) was investigated in rats, where an LD50 of 4.32 mg100 g was computed, with 95% confidence limits of 5.40 and 3.46 mg100 g. At toxic levels (4 mg100 g) the rats showed a drop of blood pressure, hemorrhages and renal failure, whereas lower doses were well tolerated.
D.L. Lips, P.S. Edwards, C.A. Pierach
openaire +2 more sources
The toxicity of intravenously administered hematin (3.4 and 6 mg100 g) was investigated in rats, where an LD50 of 4.32 mg100 g was computed, with 95% confidence limits of 5.40 and 3.46 mg100 g. At toxic levels (4 mg100 g) the rats showed a drop of blood pressure, hemorrhages and renal failure, whereas lower doses were well tolerated.
D.L. Lips, P.S. Edwards, C.A. Pierach
openaire +2 more sources
New England Journal of Medicine, 1975
The discovery that hematin represses induction of δ-aminolevulinic acid synthetase (ALA-S), the rate-limiting enzyme for hepatic porphyrin and heme synthesis,1 is central to recent studies seeking to provide a means of terminating or ameliorating the acute attack of acute intermittent porphyria, porphyria variegata or hepatic coproporphyria.
openaire +2 more sources
The discovery that hematin represses induction of δ-aminolevulinic acid synthetase (ALA-S), the rate-limiting enzyme for hepatic porphyrin and heme synthesis,1 is central to recent studies seeking to provide a means of terminating or ameliorating the acute attack of acute intermittent porphyria, porphyria variegata or hepatic coproporphyria.
openaire +2 more sources
Archives of Internal Medicine, 1978
Among the numerous throw-aways that the mailman delivers to my door are advertisements from pharmaceutical companies concerning drugs and related products. I recently received a set of complimentary starter prescriptions for a certain drug for the treatment of "iron deficiency anemia and megaloblastic anemia." The drug is composed of ferrous fumarate,
openaire +3 more sources
Among the numerous throw-aways that the mailman delivers to my door are advertisements from pharmaceutical companies concerning drugs and related products. I recently received a set of complimentary starter prescriptions for a certain drug for the treatment of "iron deficiency anemia and megaloblastic anemia." The drug is composed of ferrous fumarate,
openaire +3 more sources
PEROXIDASE, HEMATIN, AND PEGYLATED-HEMATIN CATALYZED VINYL POLYMERIZATIONS IN WATER
Journal of Macromolecular Science, Part A, 2001Horseradish peroxidase-, hematin- and pegylated-hematin mediated polymerization of sodium styrene sulfonate and sodium acrylate in water is reported. Molecular weight and yields were influenced by the concentrations of hydrogen peroxide and initiator, 2,4-pentanedione.
Jayant Kumar +7 more
openaire +2 more sources
Archives of Internal Medicine, 1979
To the Editor.— Regarding the article by Fred Rosner, in the July issue of theArchives(138:1129, 1978) on shotgun hematinic therapy, I certainly concur, at least in spirit, with the idea that shotgun hematinic therapy is to be eschewed. It is unfortunate, however, that the author compromised his legitimacy by rambling and making statements that, to my
openaire +3 more sources
To the Editor.— Regarding the article by Fred Rosner, in the July issue of theArchives(138:1129, 1978) on shotgun hematinic therapy, I certainly concur, at least in spirit, with the idea that shotgun hematinic therapy is to be eschewed. It is unfortunate, however, that the author compromised his legitimacy by rambling and making statements that, to my
openaire +3 more sources
Effect of hematin in porphyric neuropathy
Neurology, 1977Early, intravenous administration of hematin in a patient with acute intermittent porphyria and severe quadriparesis may have produced partial but remarkable improvement of neuropathy, and resulted in simultaneous decline of porphyrin precursors in the blood.
Ruth Cardinal +4 more
openaire +3 more sources
Facile Synthesis of Hematinic Acid
Synthetic Communications, 1998AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mitchell Poss +2 more
openaire +3 more sources
Access to Hematin: The Basis of Chloroquine Resistance
Molecular Pharmacology, 1998The saturable uptake of chloroquine by parasites of Plasmodium falciparum has been attributed to specific carrier-mediated transport of chloroquine. It is suggested that chloroquine is transported in exchange for protons by the parasite membrane Na+/H+ exchanger [J Biol Chem 272:2652-2658 (1997)].
Stephen A. Ward +3 more
openaire +3 more sources
Journal of Medicinal Chemistry, 1999
Considerable data now support the hypothesis that chloroquine (CQ)-hematin binding in the parasite food vacuole leads to inhibition of hematin polymerization and parasite death by hematin poisoning. To better understand the structural specificity of CQ-hematin binding, 13 CQ analogues were chosen and their hematin binding affinity, inhibition of ...
Robert G. Ridley +7 more
openaire +3 more sources
Considerable data now support the hypothesis that chloroquine (CQ)-hematin binding in the parasite food vacuole leads to inhibition of hematin polymerization and parasite death by hematin poisoning. To better understand the structural specificity of CQ-hematin binding, 13 CQ analogues were chosen and their hematin binding affinity, inhibition of ...
Robert G. Ridley +7 more
openaire +3 more sources
Micro-Raman high-pressure investigation on the malaria pigment hematin anhydride (β-hematin)
Journal of Inorganic Biochemistry, 2018The effect of pressure on the Raman and fluorescence spectra of hematin anhydride (β-hematin) is reported. In a diamond-anvil cell, DAC, with applied pressures up to 41 kbar, the Raman spectrum undergoes a series of intensity enhancements and increases in energy for many of the Raman-active bands up to a pressure of ~27 kbar. At higher pressures, there
Mirela M. Barsan +4 more
openaire +3 more sources