Results 1 to 10 of about 24,019 (190)

Dataset on characterization of hemin-azide derivative and DNA oligonucleotide-hemin conjugate

Data in Brief, 2017
In this article newly synthesized azide derivative of hemin and DNA-hemin conjugate are characterized. Hemin-azide was purified using HPLC and characterized using elemental analysis, IR and NMR. The DNA-hemin conjugate was obtained via click chemistry [1]
J. Kosman, A. Stanislawska, A. Gluszynska, B. Juskowiak   +3 more
doaj   +3 more sources

Identification and Tetramer Structure of Hemin-Binding Protein SPD_0310 Linked to Iron Homeostasis and Virulence of Streptococcus pneumoniae

mSystems, 2022
Iron and iron-containing compounds are essential for bacterial virulence and host infection. Hemin is an important supplement compound for bacterial survival in an iron-deficient environment.
Kun Cao, Tianlong Zhang, Nan Li, Xiao-Yan Yang, Jianping Ding, Qing-Yu He, Xuesong Sun   +6 more
doaj   +1 more source

Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

Journal of Nanobiotechnology, 2021
Background Application of mesenchymal stem cell-derived exosomes (MSC-EXO) has emerged as a novel therapeutic strategy for myocardial infarction (MI).
Huifeng Zheng, Xiaoting Liang, Qian Han, Zhuang Shao, Yuxiao Zhang, Linli Shi, Yimei Hong, Weifeng Li, Cong Mai, Qingwen Mo, Qingling Fu, Xiaoxue Ma, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang   +16 more
doaj   +1 more source

Hemin Improves Insulin Sensitivity in Skeletal Muscle in High Fat–Fed Mice

Journal of Pharmacological Sciences, 2014
.: The present study examined whether hemin could prevent the development of high-fat diet–induced insulin resistance in the liver and skeletal muscle using a hyperinsulinemic-euglycemic clamp.
Tae-Jin Ju, Woo-Young Kwon, Yong-Woon Kim, Jong-Yeon Kim, Yong-Dae Kim, In-Kyu Lee, So-Young Park   +6 more
doaj   +1 more source

Exogenous Hemin Confers Cadmium Tolerance by Decreasing Cadmium Accumulation and Modulating Water Status and Matter Accumulation in Maize Seedlings

Agronomy, 2021
Cadmium (Cd) contamination harms plant growth and human health. The application of hemin (ferroprotoporphyrin IX) can effectively relieve abiotic stresses in plants.
Xiaoming Liu, Yao Meng, Shi Wei, Wanrong Gu   +3 more
doaj   +1 more source

Biological Oxidations and Nitrations Promoted by the Hemin–Aβ₁₆ Complex

Antioxidants, 2023
Both β-amyloid (Aβ) peptides and oxidative stress conditions play key roles in Alzheimer’s disease. Hemin contributes to the development of the disease as it possesses redox properties and its level increases in pathological conditions or traumatic brain
Silvia De Caro, Giulia De Soricellis, Simone Dell’Acqua, Enrico Monzani, Stefania Nicolis   +4 more
doaj   +1 more source

Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron

Frontiers in Physiology, 2017
Hemin plays a key role in mediating secondary neuronal injury after intracerebral hemorrhage (ICH) and the cell toxicity of hemin is thought to be due to iron that is liberated when hemin is degraded.
Yu-Fu Zhou, Chao Zhang, Chao Zhang, Guang Yang, Zhong-Ming Qian, Meng-Wan Zhang, Meng-Wan Zhang, Juan Ma, Juan Ma, Fa-Li Zhang, Fa-Li Zhang, Ya Ke   +11 more
doaj   +1 more source

Once-monthly hemin suppresses inflammatory and autoreactive CD4+ T cell responses to robustly ameliorate experimental rheumatoid arthritis

iScience, 2021
Summary: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that would permanently damage the affected joints. Unfortunately, a large proportion of RA patients fail to respond adequately to current treatments. Here, repurposing hemin and its
Bingzhi Sun, Gaojie Li, Ling Guo, Na Yin, Huan Huang, Xiaodong Wu, Runyue Huang, Min Feng   +7 more
doaj   +1 more source

Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis

Redox Biology, 2023
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO activity is elevated in numerous hemolytic conditions including sickle cell disease (SCD); however ...
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub   +16 more
doaj   +1 more source

Comparison of Characteristics and DNAzyme Activity of G4–Hemin Conjugates Obtained via Two Hemin Attachment Methods

Molecules, 2018
Two conjugation methods using different linkers were applied for the investigation of the spectral characteristics and activity of G-quadruplex (G4)–hemin conjugates.
Joanna Kosman, Krzysztof Żukowski, Bernard Juskowiak   +2 more
doaj   +1 more source