Results 221 to 230 of about 2,243 (240)
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Biliary excretion of exogenous hematin in rats
Life Sciences, 1977Abstract Rats with bile fistula were injected intravenously with single doses of hematin (5,10,20,30, and 40 mg/kg body weight). Bile samples were collected every 30 min. for 4 hours, and at longer time intervals thereafter. The concentration of hematin in the bile was measured spectrophotometrically at 590 nm.
Z. J. Petryka +4 more
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Biochemistry, 2010
The malaria parasite pigment, hemozoin, is a crystal of ferriprotoporphyrin IX (FP-Fe(III)), a product of hemoglobin digestion. Hemozoin formation is essential for FP-Fe(III) detoxification in the parasite; it is the main target of quinoline antimalarials and can modulate immune and inflammation responses.
Klonis, Nectarios. +7 more
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The malaria parasite pigment, hemozoin, is a crystal of ferriprotoporphyrin IX (FP-Fe(III)), a product of hemoglobin digestion. Hemozoin formation is essential for FP-Fe(III) detoxification in the parasite; it is the main target of quinoline antimalarials and can modulate immune and inflammation responses.
Klonis, Nectarios. +7 more
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Shotgun Hematinic Therapy-Reply
Archives of Internal Medicine, 1979In Reply.— Dr Lutz's concluding remark is that my statement "the patient suffers both medically and financially" from the use of shotgun hematinic therapy is totally unsubstantiated, except by rhetoric. Yet, Dr Lutz's entire letter is unsubstantiated rhetoric, most of it erroneous and/or inaccurate.
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Hematin therapy for the neurologic crisis of tyrosinemia
The Journal of Pediatrics, 1991Hereditary tyrosinemia (tyrosinemia type I) is an autosomal recessive disorder caused by a defect of the final enzyme in tyrosine metabolism. The disease is associated with renal tubular defects, acute and chronic liver failure, and hepatocellular carcinoma.
Alvaro Pascual-Leone +6 more
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Effect of Hematin in Acute Porphyric Relapse
Annals of Internal Medicine, 1973Abstract The intravenous administration of hematin, in a patient with acute intermittent porphyria in relapse, was followed by a rapid decline of porphyrin precursors in the blood and urine, togeth...
Z J Petryka +4 more
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Treatment of acute hepatic porphyria with hematin
Journal of Hepatology, 1988The efficacy of hematin has been evaluated in eight patients with acute intermittent porphyria: six with acute attacks and two with chronic subacute symptoms. Hematin suppressed the chemical signs of porphyria in all patients and the symptoms in those with acute attacks.
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Hematin Therapy in Acute Porphyria
JAMA: The Journal of the American Medical Association, 1985To the Editor.— I was interested to read Dr Bissell's answer to the challenging question concerning the use of hematin in the patient with acute intermittent porphyria (AIP) and pregnancy, which would also apply in hereditary coproporphyria (HCP) and variegate porphyria (VP). 1,2 We recently have had clinical experience with this difficult situation.
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Biochemical and Biophysical Research Communications, 1967
Fook Choy Yong, Tsoo E. King
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Fook Choy Yong, Tsoo E. King
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Interactions of quinoline antimalarials with hematin in solution
Journal of Inorganic Biochemistry, 2006Quinoline antimalarial drugs such as chloroquine and related compounds are believed to act by targeting ferriprotoporphyrin IX (Fe(III)PPIX) in the form of hematin (H(2)O/HO-Fe(III)PPIX), its mu-oxo dimer ([Fe(III)PPIX](2)O) or crystalline beta-hematin ([Fe(III)PPIX](2)) in the malaria parasite.
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