Results 131 to 140 of about 99,201 (311)

Morphologic leukemia-free state in acute myeloid leukemia is sufficient for successful allogeneic hematopoietic stem cell transplant

Blood Cancer Journal, 2021
Cindy M. Pabon, Zhiguo Li, Therese Hennig, Carlos de Castro, Jadee L. Neff, Mitchell E. Horwitz, Thomas W. LeBlanc, Gwynn D. Long, Richard D. Lopez, Anthony D. Sung, Nelson Chao, Cristina Gasparetto, Stefanie Sarantopoulos, Donna B. Adams, Harry Erba, David A. Rizzieri   +15 more
doaj   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus

Communications Medicine
Background Although the mpox global health emergency caused by mpox virus (MPXV) clade IIb.1 has ended, mpox cases are still reported due to low vaccination coverage and waning immunity.
Flavia Chiuppesi, John A. Zaia, Miguel-Angel Gutierrez-Franco, Sandra Ortega-Francisco, Minh Ly, Mindy Kha, Taehyun Kim, Shannon Dempsey, Swagata Kar, Alba Grifoni, Alessandro Sette, Felix Wussow, Don J. Diamond   +12 more
doaj   +1 more source

Successful treatment with fludarabine and cyclophosphamide in a VEXAS syndrome patient with associated myelodysplastic syndrome: a case report and systematic review

Frontiers in Oncology
Vacuoles, E1 syndrome, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a chronic inflammatory disorder that affects various organ systems. It is associated with hematologic malignancies and is generally refractory to therapies.
Polina Bellman, Jesus D. Gonzalez-Lugo, Moazzam Shahzad, Moazzam Shahzad, Muhammad Kashif Amin, Muhammad Fareed Khalid, Nahid Suleman, Nausheen Ahmed, Anurag K. Singh, Abdulraheem Yacoub, Da Zhang, Joseph P. McGuirk, Muhammad Umair Mushtaq   +12 more
doaj   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Ferroptosis: a new mechanism of traditional Chinese medicine for treating hematologic malignancies [PDF]

Ferroptosis is a recently identified form of cell death characterized by lipid peroxidation and elevated iron levels. It is closely associated with hematologic malignancies, including leukemia, multiple myeloma (MM), and myelodysplastic syndromes (MDS ...
Xinyue Gou, Xudong Tang, Zhuo Chen, Chi Liu   +3 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Ocular pathology of uncommon hematologic malignancies: a case series

, 2007
Introduction In general, ocular complications of hematologic malignancies such as leukemia are well documented. However, reports of ocular involvement in such diseases as lymphomatoid granulomatosis and chronic myelomonocytic leukemia are uncommon.
Head James E, Shen Defen, Bishop Rachel J, Santiago-Maysonet Maribel, Chan Chi-Chao, Defen Shen, Maribel Santiago-Maysonet, Chi-Chao Chan, James E Head, Rachel J Bishop   +9 more
core   +1 more source

Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor

, 2020
Germ cell tumors (GCTs) are the most common cancer in men between the ages of 15 and 40. Although most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes.
Tamari, Roni, Iacobuzio-Donahue, Christine A., Baez, Priscilla, Ho, Caleb, Al-Ahmadie, Hikmat A., Funt, Samuel A., Aypar, Umut, Tickoo, Satish K., Haddadin, Michael, Reuter, Victor E., Petrova-Drus, Kseniya, Tallman, Martin S., Solit, David B., Abdel-Wahab, Omar, Taylor, Justin, Rao, Pavitra, Rampal, Raajit K., Feldman, Darren R., Kappagantula, Rajya, Dogan, Ahmet, Chavan, Shweta S., Bosl, George J., Kosuri, Satyajit, Donoghue, Mark T.A., Taylor, Barry S., Giralt, Sergio, Zhang, Yanming   +26 more
core   +1 more source