Results 81 to 90 of about 218,075 (284)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim +11 more
wiley +1 more source
Hepatic histologic phenotype in malignant hematologic neoplasms [PDF]
Background. Hepatic involvement in malignant hematologic neoplasms is common, yet often underdiagnosed. The spectrum of lesions ranges from minimal changes to acute liver failure, and hepatic histopathological evaluation is essential for the early ...
Berliba, Elina, Pîrțac, Iuliana
core
Pathophysiology of thrombosis in myeloproliferative neoplasms [PDF]
, 2011 Life expectancy of patients with myeloproliferative neoplasms (MPNs) and particularly that of subjects with polycythemia vera (PV) and essential thrombocythemia (ET) has significantly increased over the last three decades, largely due to the use of ...
Landolfi, Raffaele +3 more
core +1 more source
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor [PDF]
, 2020 Germ cell tumors (GCTs) are the most common cancer in men between the ages of 15 and 40. Although most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes.
Tamari, Roni +53 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Hematologic malignancies during preg
, 2016 Malignancy is the second most common cause of mortality in the reproductive period and it complicates up to one out of every 1000 pregnancies. When cancer is diagnosed during pregnancy, the management approach must take into consideration both the mother
Gamal M. Fathy +2 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
New WHO classification of neoplastic diseases of the hematopoietic and lymphoid tissues. IV. Histiocytic and mast cell neoplasms [PDF]
, 2001 В соответствии с предлагаемой экспертами ВОЗ классификацией различают следующие основные группы гемобластозов: миелоидные опухоли, лимфоидные новообразования, гистиоцитарные опухоли и опухоли, возникающие из тучных клеток. В данном сообщении представлены
Абраменко, И.В. +3 more
core +2 more sources