Results 81 to 90 of about 117,284 (247)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Cutaneous Clue to Clonal Evolution: Sweet’s Syndrome Heralding Hematologic Progression in Essential Thrombocythemia

Case Reports in Hematology
Sweet’s syndrome, or acute febrile neutrophilic dermatosis, is a rare inflammatory condition that may occur idiopathically or in association with malignancy, drugs, or systemic disease. Among malignancy-associated cases, hematologic neoplasms predominate.
Kavya Ronanki, Bibhant Shah, Prisla Maria Dalton, Nikhil Nagpal, Kartik Saini, null Sushantika, Nilotpal Chowdhury, Uttam Kumar Nath   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

[Hematologic neoplasms and pregnancy].

Medicina, 1995
Hematologic neoplasms diagnosed during pregnancy, present significant difficulties in patient management. Besides the strictly medical facts, moral, ethical and religious issues should be strongly considered. For the optimal management of individual situations an integrated multidisciplinary approach is mandatory.
N, Tartas, R, Chacón, J C, Sánchez Avalos   +2 more
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Glomerular diseases associated with hematopoietic neoplasms: an expanding spectrum [PDF]

, 2011
Once thought to be limited mainly to lesions involving deposition of monoclonal paraproteins, glomerular diseases associated with hematologic neoplasms now include forms in which manifestations are probably mediated through cytokines or chemokines.
Christine VanBeek, Mark Haas, Haas, Mark, VanBeek, Christine   +3 more
core   +1 more source

Serous Neoplasms

, 2022
Serous pancreatic neoplasms are cystic tumors, usually detected as solitary lesions. The most common is the serous cystadenoma (SCA).
Gobbo, Stefano, D'Onofrio, Mirko, Capelli, Paola, de Robertis, Riccardo, Martini, Paolo Tinazzi, Morana, Giovanni, Luchini, Claudio   +6 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Flow cytometry, cytology and histology in the diagnosis of ocular hematologic neoplasms: a 15-year monocentric experience with a focus on ocular lymphomas

Objectives: Ocular lymphomas are rare diseases that occur in ocular adnexa or specific intraocular regions. Although histology remains the gold standard, cytology and flow cytometry (FCM) are fundamental, mainly when a biopsy sampling is technically ...
Finotto, Silvia, Midena, Giulia, Pizzi, Marco, Marino, Dario, Vianello, Federica, Montagnana, Martina, Molin, Carolina, Fogar, Paola, Falda, Alessandra, Turkman, Jasmine, Zuin, Jenny, Parrozzani, Raffaele, Basso, Daniela, Dei Tos, Angelo Paolo, Davanzo, Veronica   +14 more
core   +1 more source

Cystic Lesions of the Pancreas [PDF]

, 2014
With the increasing use of abdominal imaging, cystic lesions of the pancreas are being more frequently detected. These lesions may carry a significant premalignant potential.
Azzopardi, Neville
core