Results 91 to 100 of about 84,691 (282)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pathophysiology of thrombosis in myeloproliferative neoplasms [PDF]

, 2011
Life expectancy of patients with myeloproliferative neoplasms (MPNs) and particularly that of subjects with polycythemia vera (PV) and essential thrombocythemia (ET) has significantly increased over the last three decades, largely due to the use of ...
Landolfi, Raffaele, L. Di Gennaro, Di Gennaro, Leonardo, R. Landolfi   +3 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

CXCR Family and Hematologic Malignancies in the Bone Marrow Microenvironment

Biomolecules
Malignant hematologic diseases, also referred to as hematologic tumors, encompass a series of malignant proliferative disorders of the lymphopoietic system, including leukemia, lymphoma, multiple myeloma, and myeloproliferative neoplasms.
Yanquan Liu, Huanwen Tang
doaj   +1 more source

Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells

Frontiers in Pharmacology, 2018
Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic ...
Satoshi Imanishi, Tomohiro Umezu, Chiaki Kobayashi, Tomohiko Ohta, Kazuma Ohyashiki, Junko H. Ohyashiki   +5 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Direct Oral Anticoagulants In Patients With Hematologic Malignancies

, 2020
The anticoagulant treatment for patients with hematologic malignancies is low molecular weight heparin (LMWH), considered the safest in this particular patients setting. Although direct oral anticoagulants (DOACs) have proven their efficacy and safety in
Chistolini, Antonio, Maria L. De Luca, Serrao, Alessandra, Santoro, Cristina, Alessandra Serrao, Luciano Fiori, Antonietta Ferretti, Ferretti, Antonietta, De Luca, Giulia, Cristina Santoro, Antonio Chistolini, Ligia, Silvio, Fiori, Luciano, Massimo Breccia, Mohamed, Sara, Gianfranco Lapietra, Sara Mohamed, Lapietra, Gianfranco, De Luca, Maria Lucia, Breccia, Massimo, Giulia De Luca, Silvio Ligia   +21 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Not only a therapeutic target; mTOR in Hodgkin lymphoma and acute lymphoblastic leukemia

Frontiers in Oncology
IntroductionThe mechanistic/mammalian target of rapamycin (mTOR) is a serine/threonine kinase, which is downregulated or upregulated and is implicated in different types of cancer including hematologic neoplasms, skin prostate, and head and neck cancer ...
Miguel Enrique Cuéllar Mendoza, Miguel Enrique Cuéllar Mendoza, Francisco Raúl Chávez Sánchez, Elisa María Dorantes Acosta, Ana María Niembro Zúñiga, Rosana Pelayo, Marta Zapata Tarrés   +6 more
doaj   +1 more source