Results 131 to 140 of about 82,980 (311)

Extended Lake Louise Score: a novel standard evaluation of cognitive impairment for immigrants' rapid ascent to high altitude

Travel Medicine and Infectious Disease
Objective: To extend the Lake Louise Scoring (LLS) system to better assess cognitive impairment, and investigate the early changes of hematological indicators for subjects of rapid ascent to high altitude.
Tao Xu, Wen Li, Chun-Yan Zhang, Bo Dong, Tao Luo, Jian-Guo Huang, Jin-Long Shi, Jun Tang, Shi-Jun Li   +8 more
doaj   +1 more source

Hematologic disorders associated with ischemic stroke

, 2008
Hematological disorders underlie a small proportion of all ischemic strokes. The association of these coagulation abnormalities with ischemic stroke is not always clear. The etiology of stroke still remains uncertain in a large number of cases and proper
Tatlisumak, Turgut, Fisher, Marc
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Predicting the risk of threatened abortion using machine learning methods: a comparative study

BMC Pregnancy and Childbirth
Background and objective Threatened abortion, a common pregnancy complication that often leading to abortion, is hard to predict due to its non-specific symptoms and difficulty in differentiating from other early pregnancy bleeding causes.
Zhenning Zhu, Na Wei, Junjie Guo, Changlei Yue, Chao Chen, Zicheng Zhang, Shiyu Wu, Jie Su, Biao Song   +8 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The Impact of Hematologic Disorders on the Severity of Cerebral Venous Sinus Thrombosis: A Comparative Study

Clinical and Applied Thrombosis/Hemostasis
Hematologic diseases are considered important contributors to cerebral venous sinus thrombosis (CVST) cases. This retrospective study aims to compare the difference of the clinical and radiological characters between CVST patients with and without ...
Mengqi Wang MD, Xiangqian Huang MD, Yuchuan Ding Ph.D, Xunming Ji MD, PhD, Ran Meng MD, PhD   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

A framework for the clinical implementation of optical genome mapping in hematologic malignancies [PDF]

Optical Genome Mapping (OGM) is rapidly emerging as an exciting cytogenomic technology both for research and clinical purposes. In the last 2 years alone, multiple studies have demonstrated that OGM not only matches the diagnostic scope of conventional ...
Kolhe, Ravindra, Neveling, Kornelia, Clifford, Benjamin, Hoischen, Alexander, Neveling, Nikhil S., Sole, F, Stevens-Kroef, Marian, Puiggros, Anna, Espinet Solà, Blanca, Sahajpal, Rashmi Kanagal, Mantere, Tuomo, Sahajpal, Nikhil S, Solé, Francesc, Levy, Brynn, Mallo, Mar, Puiggros Metje, Anna Maria, Dewaele, Barbara, Espinet, Blanca, Olde Weghuis, Daniel, Smith, Adam C., Levy, Brinn, Raca, Gordana, Sahajpal, Nikhil S., Rack, Katrina, Universitat Autònoma de Barcelona, Smith, Adam C, Kanagal-Shamanna, Rashmi   +26 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source