Results 261 to 270 of about 474,063 (338)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Integrated assessment of brackish water induced deleterious impacts: Analysis of hemato-biochemistry, erythrocytic toxicity, histopathology and oxidative stress biomarkers of mrigal carp. [PDF]

PLoS One
Raza GA, Hussain R, Ghaffar A, Mohiuddin M, Riaz R, Nawaz S, Ölmez M, Fouad D, Virk P.   +8 more
europepmc   +1 more source

Factors and Considerations in No‐Treatment Decisions in Patients With Key Hematological Malignancies: A Nationwide, Population‐Based Study in the Netherlands

Myrte Zijlstra, Rolf A. H. Snijders, Fransien de Boer, Martine E.D. Chamuleau, Heidi P. Fransen, Simone Oerlemans, Annemieke van der Padt‐Pruijsten, Eduardus F. M. Posthuma, Otto Visser, Sonja Zweegman, Natasja Raijmakers, Avinash G. Dinmohamed   +11 more
openalex   +2 more sources

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Tracking temporal shifts of peripheral blood NLR, PLR, and ALB: a prognostic tool for PD-1 inhibitor efficacy in advanced malignant melanoma. [PDF]

Front Oncol
Deng Y, Han Y, Meng X, Pei J, Yang M, Xiao Z, Wang F, Lu T.   +7 more
europepmc   +1 more source

Effect of the SARS-CoV-2 viral load on hematological and biochemical parameters

Gustavo Caires Neves Magalhães, Clayson Moura Gomes, Leandro do Prado Assunção, Sérgio Henrique Nascente Costa, Fernando Antônio Vinhal dos Santos, Keila Correia de Alcântara   +5 more
openalex   +2 more sources

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Can routine hematological markers improve obesity risk stratification? A translational comment on El-Aghbary et al. [Response to Letter]. [PDF]

Diabetes Metab Syndr Obes
El-Aghbary DA, Thabet RA, Almorish MAW, Al-Sayaghi KM, Elkhalifa AME.   +4 more
europepmc   +1 more source

Relationship of Interleukin – 8 levels with some hematological and biochemical parameters in patients with chronic hepatitis B and C infection

, 2014
Hameed M. Majeed, Mazin Razooqi Mohammed, Zeena A. Abd Al-Razak   +2 more
openalex   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source