Results 181 to 190 of about 584,870 (306)

Impact of fitness categorization according to SIE/SIES/GITMO criteria in therapy-related and AML-MRC receiving CPX-351. [PDF]

Blood Adv
Palmieri R, Guolo F, Fianchi L, Ferrara F, Minetto P, Martelli MP, Riva C, Chiusolo P, Rondoni M, Capria S, Minotti C, Pilo F, Perrone S, Corbingi A, Grimaldi F, De Luca G, Fili C, Alati C, Mannelli F, Lessi F, Marchesi F, Brunetti L, Capelli D, Piccioni AL, Vetro C, Palumbo FE, Mazzone C, Sperotto A, Luzi G, Dargenio M, Mariani S, Cerrano M, Mulè A, Di Veroli A, Meddi E, Moretti F, Papayannidis C, Isidori A, Ferrari A, Galimberti S, Cilloni D, Breccia M, Lanza F, Gottardi M, Cairoli R, Candoni A, Pagano L, Todisco E, Lemoli RM, Venditti A, Buccisano F.   +50 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Correction to: A meta-analysis of immunosuppressive and Pharmacological therapies in aplastic anaemia with and without Indigenous equine antithymocyte Globulin (eATG). [PDF]

Ann Hematol
George B, Ross RC, Damodar S, Seth T, Dolai KT, Banerjee S, Manguesh R, Malhotra P.   +7 more
europepmc   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Correction: CircEAF2 counteracts Epstein-Barr viruspositive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/β-catenin axis. [PDF]

Mol Cancer
Zhao CX, Yan ZX, Wen JJ, Fu D, Xu PP, Wang L, Cheng S, Hu JD, Zhao WL.   +8 more
europepmc   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Assessment of characteristics and treatment patterns of adult patients with acquired aplastic anemia in Turkiye (PLANE-TR). [PDF]

Ann Hematol
Gunduz E, Ulas T, Ozkalemkas F, Toprak SK, Karakulak EA, Ar MC, Gulbas Z, Ozkocaman V, Aydogan M, Buyukasik Y, Cerme MDO, Mehtap O, Kucur D, Kaya E, Yavasoglu I, Besisik SK, Ersal T, Yuksel M, Hacioglu S, Hacibekiroglu T, Kaya A, Sakci E, Yuksel MK, Ozet G, Cagliyan GA, Hasanzade U, Salim O, Pepeler MS, Turgut M, Kurekci DD, Giden AO, Sener S, Calika S, Dal MS.   +33 more
europepmc   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Benefit of rituximab maintenance after first-line bendamustine-rituximab in patients with mantle cell lymphoma. [PDF]

Blood Adv
Wang Y, Larson MC, Hwang SR, Villa D, Kugathasan L, Kumar A, Joseph A, Brooks TR, Hill BT, Bond DA, Maddocks KJ, Nizamuddin IA, Kahl BS, Danilov A, Argao C, Ruan J, Ryan CE, Merryman RW, Grover NS, Khan NB, Ouchveridze E, Tun AM, Ayyappan S, Mou E, Pongas GN, Lossos IS, Harris ZI, Munoz JL, Young P, Portell CA, Baidoun F, Alhaj Moustafa M, Reagan PM, Banaszak LG, Pophali PA, Velayati A, Greenwell IB, Gerber D, Jain P, Wang ML, Narkhede MS, Mehta A, Stack AC, Messmer MR, Bhansali RS, Barta SK, Moyo TK, Ghosh N, Kamdar MK, Anna J, Stanisic AV, Karmali R, Maurer MJ, Cerhan JR, Cohen JB, Martin P.   +55 more
europepmc   +1 more source

Blood signals: from birth to disease and death

, 2014
Bowman, T., Flores-Figueroa, E., King, K., Kokkaliaris, K., Lessard, J., Trompouki, E., Will, B.   +6 more
core   +1 more source