Results 201 to 210 of about 584,870 (306)

Comprehensive geriatric assessment (CGA) scale does not effectively identify elderly AML patients suitable for intensive induction chemotherapy - a multicenter study from Polish Adult Leukemia Group. [PDF]

Ann Hematol
Budziszewska BK, Łomiak M, Barankiewicz J, Patkowska E, Helbig G, Bołkun Ł, Irga-Staniukiewicz A, Kiżewska A, Piekarska A, Koclęga A, Pluta A, Kuydowicz M, Kościołek-Zgódka S, Cichocka E, Malenda A, Wójcik K, Gromek T, Małecki P, Grosicki S, Giebel S, Wierzbowska A, Lech-Marańda E.   +21 more
europepmc   +1 more source

Super‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression

Advanced Science, EarlyView.
Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...
Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi   +22 more
wiley   +1 more source

Hypertriglyceridemia During Anticancer Therapy in Pediatric Patients with Acute Lymphoblastic Leukemia - A Nationwide Experience. [PDF]

Cancer Manag Res
Zawitkowska J, Latoch E, Karska K, Drabko K, Lejman M, Paczóska KE, Ociepa T, Malecka A, Sęga-Pondel D, Kalwak K, Konończuk K, Kołodrubiec J, Trelińska J, Demidowicz E, Andrzejewska M, Derwich K, Zakrzewska Z, Skoczeń S, Mizia-Malarz A, Karolczyk G, Bal W, Chaber R, Tyszka P, Badowska W, Janiszewska M, Kowalczyk J, Młynarski W, Szczepański T, Styczyński J, Irga-Jaworska N, Muszyńska-Rosłan K.   +30 more
europepmc   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Anticoagulation management and monitoring in ECMO: an international survey: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis. [PDF]

Res Pract Thromb Haemost
Regling K, Thomas R, Faustino EVS, Goldenberg NA, Chitlur M.   +4 more
europepmc   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

A 35-year-old man with immune thrombotic thrombocytopenic purpura presenting with dark urine. [PDF]

CMAJ
Bhangu G, Arreglo R, Merkeley H.
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Long term outcomes of the Indian childhood cancer survivorship (C2S) cohort: a multicentre study (2016-2024). [PDF]

Lancet Reg Health Southeast Asia
Seth R, Kapoor G, Moulik NR, Kaushik P, Verma N, Mahajan A, T P, Radhakrishnan N, Raj R, Singh A, Sharma S, Radhakrishnan V, Rani S, Bhattacharyya P, Krishnan Y, Mandal P, Rahiman EA, Jain P, Sahoo D, Mohapatra D, Das G, Gupta V, Singh G, Kakkar S, Singh A, Prabhakar P, Kumar Ar A, Meena JP, Gupta AK, Malhotra P, Kumar C, Didel S, Arora SK, Patil V, Prakash A, Kanvinde P, Prasad M, Chandra J, Kurkure P, Arora R.   +39 more
europepmc   +1 more source

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source