Results 81 to 90 of about 575,997 (353)

Successful Treatment of Diffuse Large B-Cell Lymphoma and Antisynthetase Syndrome with Bispecific Antibody Glofitamab

Cancer Management and Research
Chong Wei,1,* Mei Zhang,2,* Danqing Zhao,1 Wei Zhang,1 Yan Zhang2 1Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ...
Wei C, Zhang M, Zhao D, Zhang W, Zhang Y
doaj  

Comparative Health Assessments of Alaskan Ice Seals

Frontiers in Veterinary Science, 2019
Bearded (Erignathus barbatus), ringed (Pusa hispida), spotted (Phoca largha), and ribbon (Histriophoca fasciata) seals rely on seasonal sea-ice in Arctic and sub-Arctic regions.
Caroline E. C. Goertz, Colleen Reichmuth, Colleen Reichmuth, Nicole M. Thometz, Nicole M. Thometz, Heather Ziel, Peter Boveng   +6 more
doaj   +1 more source

Splenomegaly impacts prognosis in essential thrombocythemia and polycythemia vera: A single center study [PDF]

, 2019
Splenomegaly is one of the major clinical manifestations of primary myelofibrosis and is common also in other chronic Philadelphia-negative myeloproliferative neoplasms, causing symptoms and signs and affecting quality of life of patients diagnosed with ...
Accurso V., Casimiro P., Contrino A. D., Di Piazza F., Perez A., Raso S., Russo A., Santoro M., Siragusa S.   +8 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Growth Differentiation Factor-15 as a Potential Biomarker for Renal Involvement in POEMS Syndrome

International Journal of Nephrology and Renovascular Disease
Yuan Huang,1,* Jia Chen,2,* Yanlan Yao,3,* Lu Zhang,2 Yongzhe Li,1 Jian Li2 1Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing ...
Huang Y, Chen J, Yao Y, Zhang L, Li Y, Li J   +5 more
doaj  

Gaucher Disease and Myelofibrosis: A Combined Disease or a Misdiagnosis? [PDF]

, 2018
Background: Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting in a misdiagnosis.
Cardarelli, L, Foà, R, Giona, F, Mariani, S, Palumbo, G, Santopietro, M   +5 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Prognostic Implications of Red Blood Cell Distribution Width to Albumin Ratio in Myelofibrosis: A 10-Year Multicenter and Retrospective Study

Journal of Inflammation Research
Tian Zeng,1,* Zhikang Zheng,1,2,* Honglan Qian,3,* Lirong Liu,4,* Xiaowei Shi,5,* Yanping Shao,6,* Zhaohao Huang,7 Rumeng Li,1 Bingbing Wen,1 Qingmei Han,1,8 Qiutian Feng,1,2 Lingrong Tu,1,2 Xiaojing Bao,1 ...
Zeng T, Zheng Z, Qian H, Liu L, Shi X, Shao Y, Huang Z, Li R, Wen B, Han Q, Feng Q, Tu L, Bao X, Tong H, Jin J, Huang J   +15 more
doaj  

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. [PDF]

, 2019
BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have ...
Akan, H, Alexander, BD, Andes, D, Azoulay, E, Baddley, JW, Bassetti, M, Bialek, R, Bradsher, RW, Bretagne, S, Calandra, T, Caliendo, AM, Castagnola, E, Chen, SC, Clancy, CJ, Cruciani, M, Cuenca-Estrella, M, Decker, CF, Desai, SR, Donnelly, JP, Fisher, B, Groll, AH, Harrison, T, Heussel, CP, Jensen, HE, Kauffman, CA, Kibbler, CC, Kontoyiannis, DP, Kullberg, B-J, Lagrou, K, Lamoth, F, Lehrnbecher, T, Lockhart, SR, Loeffler, J, Lortholary, O, Maertens, J, Marchetti, O, Marr, KA, Masur, H, Meis, JF, Morrisey, CO, Nucci, M, Ostrosky-Zeichner, L, Pagano, L, Pappas, PG, Patterson, TF, Perfect, JR, Prokop, CS, Racil, Z, Roilides, E, Ruhnke, M, Shoham, S, Slavin, MA, Sorrell, TC, Steinbach, WJ, Stevens, DA, Thompson, GR, Vazquez, JA, Verweij, PE, Viscoli, C, Walsh, TJ, Warris, A, Wheat, LJ, White, PL, Wingard, JR, Zaoutis, TE   +64 more
core   +5 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source