Results 171 to 180 of about 121,287 (371)

Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models

Advances in Hematology, 2012
Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors.
Raman Sood, Paul Liu
doaj   +1 more source

Hematopoiesis in Long-Term Survival Following Supralethal Irradiation and Bone Marrow Transplantation in Dogs [PDF]

, 1968
J. L. Chertkov, M.N. Novikova, N. M. Nemenova, V. N. Malanina   +3 more
openalex   +1 more source

Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity

Advanced Science, EarlyView.
Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren, Xiaotong Xu, Zheng Dong, Jiahuang Qiu, Qing'e Shan, Rui Chen, Yajun Liu, Juan Ma, Sijin Liu   +8 more
wiley   +1 more source

Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T‐cell lymphoblastic leukemia

HemaSphere
T‐lineage acute lymphoblastic leukemia (T‐ALL) is an aggressive hematological malignancy that accounts for 10%–15% of pediatric and 25% of adult ALL cases. Although the prognosis of T‐ALL has improved over time, the outcome of T‐ALL patients with primary
André Almeida, Sara T'Sas, Luca Pagliaro, Igor Fijalkowski, Wouter Sleeckx, Hannah Van Steenberge, Raffaella Zamponi, Béatrice Lintermans, Wouter Van Loocke, Bruno Palhais, Alexandra Reekmans, Valentina Bardelli, Lisa Demoen, Lindy Reunes, Dieter Deforce, Filip Van Nieuwerburgh, Alex Kentsis, Panagiotis Ntziachristos, Nadine Van Roy, Barbara De Moerloose, Cristina Mecucci, Roberta La Starza, Giovanni Roti, Steven Goossens, Pieter Van Vlierberghe, Tim Pieters   +25 more
doaj   +1 more source

Apply Distributed CNN on Genomics to accelerate Transcription-Factor TAL1 Motif Prediction [PDF]

Big Data works perfectly along with Deep learning to extract knowledge from a huge amount of data. However, this processing could take a lot of training time. Genomics is a Big Data science with high dimensionality. It relies on deep learning to solve complicated problems in certain diseases like cancer by using different DNA information such as the ...
arxiv   +1 more source

GENE CONTROL OF HEMATOPOIESIS [PDF]

, 1969
Beatrice Mintz, Joy Palm
openalex   +1 more source

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

Cell, 2021
A. Heyde, David Rohde, Johannes G. Reiter, K. Naxerova   +3 more
semanticscholar   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

High-dimensional switches and the modeling of cellular differentiation [PDF]

arXiv, 2004
Many genes have been identified as driving cellular differentiation, but because of their complex interactions, the understanding of their collective behaviour requires mathematical modelling. Intriguingly, it has been observed in numerous developmental contexts, and particularly hematopoiesis, that genes regulating differentiation are initially co ...
arxiv  

Brief Report: Use of Phytohemagglutinin to Stimulate Hematopoiesis in Humans [PDF]

, 1966
Donald M. Hayes, Charles L. Spurr
openalex   +1 more source