Results 201 to 210 of about 80,377 (264)

Real-ambient PM_2.5 exposure disrupts hematopoietic homeostasis via HIF-1α-driven myeloid skewing and promotes organ inflammation. [PDF]

Part Fibre Toxicol
Yu H, Chen Y, Wang Y, Li M, Tang G, Zhang R, Qu G, Jin X, Zheng Y, Jiang G.   +9 more
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

The Predictive Value of Hemoglobin Glycation Index and Clonal Hematopoiesis of Indeterminate Potential Among AMI Patients-A Prospective Registry Study. [PDF]

J Diabetes
Xue L, Dong W, Li J, Chen R, Li N, Liu C, Zhou P, Chen Y, Song L, Zhao X, Yan H, Zhao H.   +11 more
europepmc   +1 more source

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source

TET2 in epigenetic control of immune cells: Implications for inflammatory responses and age-related pathologies. [PDF]

J Biol Chem
Obrebski T, Maleszewska M, Dunin-Horkawicz S, Malik AR.   +3 more
europepmc   +1 more source

Inside a duck‐billed dinosaur: Vertebral bone microstructure of Huallasaurus (Hadrosauridae), Upper Cretaceous of Patagonia

The Anatomical Record, EarlyView.
Abstract Dinosaurs evolved a unique respiratory system with air sacs that contributed to their evolutionary success. Postcranial skeletal pneumaticity (PSP) has been used to infer the presence of air sac systems in some fossil archosaurs. While unambiguous evidence of PSP is well documented in pterosaurs and post‐Carnian saurischians, it remains absent
Tito Aureliano, Aline M. Ghilardi, Jonatan Kaluza, Agustín G. Martinelli   +3 more
wiley   +1 more source

Dynamic activity of Erg promotes maturation of the hematopoietic system. [PDF]

Blood Adv
Tanaka-Yano M, Sugden WW, Wang D, Falchetti M, Badalamenti B, Côté P, Chin D, Goldstein J, George S, Rodrigues-Luiz GF, Lummertz da Rocha E, Li H, North TE, Gryder BE, Rowe RG.   +14 more
europepmc   +1 more source

Association of infection frequency and incident clonal hematopoiesis of indeterminant potential. [PDF]

Exp Hematol
Lapite A, Burk VA, DeCuir J, Ishigami J, Saadatagah S, Natarajan P, Ballantyne CM, Platz EA, King KY.   +8 more
europepmc   +1 more source