Results 241 to 250 of about 155,178 (360)

Blood signals: from birth to disease and death

, 2014
Bowman, T., Flores-Figueroa, E., King, K., Kokkaliaris, K., Lessard, J., Trompouki, E., Will, B.   +6 more
core   +1 more source

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source

BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus. [PDF]

Elife
Ning G, Lin Y, Ma H, Zhang J, Yang L, Liu Z, Li L, He X, Wang Q.   +8 more
europepmc   +1 more source

Changes in hematopoiesis-supporting ability of C3H10T1/2 mouse embryo fibroblasts during differentiation [PDF]

, 1993
Masatoshi Nishikawa, K. Ozawa, A Tojo, T Yoshikubo, Atsushi Okano, Kotaro Tani, K Ikebuchi, Hiromitsu Nakauchi, Shinji Asano   +8 more
openalex   +1 more source

Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis‐Associated Tumorigenesis

Advanced Science, EarlyView.
A fecal microbial meta‐analysis reveals that Megasphaera is highly abundant in the Asian population with IBD and CRC. M. elsdenii reshapes colonic immunity by triggering DC cell‐mediated Th1 and Th17 inflammation. M. elsdenii and M. elsdenii‐enriched microbiota exacerbate colonic inflammation and tumorigenesis in AOM/DSS mice.
Xinxin Hou, Zhaozhou Zhang, Wanqing Chen, Jinming Li, Xiangxiang Zhu, Mingjie Li, Xiaoqi Guan, Haidong Guo, Yanlei Ma, Ling Zhao   +9 more
wiley   +1 more source

Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis. [PDF]

Cell Mol Biol Lett
Watts D, Eberz N, Jaykar MT, Sinha A, Ermis C, Tiebel J, Baschant U, Rauner M, Grinenko T, Chavakis T, Mirtschink P, El-Armouche A, Wielockx B.   +12 more
europepmc   +1 more source

Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing [PDF]

, 2020
Bangert, Celia V., Brune, Meryl K., Chang, Gue Su, Chen, David Y., Fronick, Catrina, Fulton, Robert S., George, Daniel R., Helton, Nichole M., Hoock, Mieke, Ketkar, Shamika, Leight, Elizabeth R., Ley, Timothy J., Miller, Christopher A., Petti, Allegra A., Ramakrishnan, Sai Mukund, Smith, Amanda M., Spencer, David H., Verdoni, Angela M.   +17 more
core   +1 more source

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu, Hongchao He, Shilei Qiao, Yifan Shao, Lurong Wang, Zhengkui Zhang, Long Zhang, Fangfang Zhou   +7 more
wiley   +1 more source

Human hematopoiesis and blood cell formation in pigs. [PDF]

Blood Sci
Jin CH, Tang Y, Qu L, Cheng T.
europepmc   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source