Results 271 to 280 of about 155,178 (360)

Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver. [PDF]

BMC Biol
Li X, Dong X, Zhao S, Ma Y, Jin S, Zhou C, Lan Y, Luo S, Ni B, Wei H, Yan D.   +10 more
europepmc   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

EVIDENCE THAT RESIDUAL HOST CELLS SURVIVING THE CONDITIONING REGIMEN TO ALLOGENEIC BONE MARROW TRANSPLANTATION INHIBIT DONOR HEMATOPOIESIS IN VITRO—THE ROLE OF TNF-α

, 1991
G Vinci, Salem Chouaı̈b, Brigitte Autran, Jean Paul Vernant   +3 more
openalex   +1 more source

The Deconvolution of Human Hematopoiesis

HemaSphere, 2018
openaire   +4 more sources

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage‐Derived Stem Cells

Advanced Science, EarlyView.
CDSCs exhibit the potential to differentiate into endothelial cells, vascular pericytes, and osteoblasts. These differentiated cells are capable of secreting additional pro‐hematopoietic cytokines. Furthermore, CDSCs can inhibit apoptosis and reduce DNA damage in injured hematopoietic stem and progenitor cells (HSPCs, including RHSCs and RHPCs), while ...
Rui Dong, Zhiguo Ling, Pengyuan Fan, Debao Li, Jinsong Wang, Wenjiong Shi, Rui Zuo, Runfeng Chen, Xuemin Sun, Lang Xiao, Yushi Ran, Shucheng Huang, Yi Tian, Chao Zhang, Yuzhang Wu, Bing Ni, Yi Zhang   +16 more
wiley   +1 more source

Single-cell dynamic RNA and glycosylation sequencing reveals the mechanism underlying the differentiation of pluripotent stem cells into hematopoietic stem cells. [PDF]

Hum Cell
Feng W, Zeng S, Liu D, Gong W, Hu J, Xu W, Ma Z, Fu S, Chen X.   +8 more
europepmc   +1 more source

SemiLT: A Multianchor Transfer Learning Method for Cross‐Modality Cell Label Annotation from scRNA‐seq to scATAC‐seq

Advanced Science, EarlyView.
A multianchor transfer learning method, SemiLT, enables accurate cell label annotation in sparse scATAC‐seq data by leveraging well‐annotated scRNA‐seq references. By addressing temporal discrepancies between modalities, SemiLT improves rare cell type identification and batch correction.
Zhitong Chen, Maoteng Duan, Xiaoying Wang, Bingqiang Liu   +3 more
wiley   +1 more source

Impact of clonal hematopoiesis of indeterminate potential on arterial atherothrombosis and venous thromboembolism: Protocol for a systematic review and meta-analysis. [PDF]

PLoS One
Todorovski A, Wang TF, Sterling E, Collins E, Carrier M, Siegal D, Kekre N, Khalifé R, Xu Y.   +8 more
europepmc   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source