Results 271 to 280 of about 84,742 (296)
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Blood Cells, Molecules, and Diseases, 2013
Blood cells are continually produced from a pool of progenitors that derive from hematopoietic stem cells (HSCs). In vertebrates, the hematopoietic system develops from two distinct waves or generation of precursors. The first wave occurs in the yolk sac, in mammals or equivalent embryonic structure, and produces nucleated primitive erythrocytes that ...
Golub, Rachel, Cumano, Ana
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Blood cells are continually produced from a pool of progenitors that derive from hematopoietic stem cells (HSCs). In vertebrates, the hematopoietic system develops from two distinct waves or generation of precursors. The first wave occurs in the yolk sac, in mammals or equivalent embryonic structure, and produces nucleated primitive erythrocytes that ...
Golub, Rachel, Cumano, Ana
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Immunology Letters, 2015
Recent discoveries have significantly expanded our previous knowledge about the role of bone marrow mesenchymal stem cells (BMSCs) in hematopoiesis. BMSCs and their derivatives modulate blood production and immunity at different levels but a prominent role has emerged for BMSCs in the regulation of hematopoietic stem and progenitor cells (HSPCs ...
Simón Méndez-Ferrer +3 more
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Recent discoveries have significantly expanded our previous knowledge about the role of bone marrow mesenchymal stem cells (BMSCs) in hematopoiesis. BMSCs and their derivatives modulate blood production and immunity at different levels but a prominent role has emerged for BMSCs in the regulation of hematopoietic stem and progenitor cells (HSPCs ...
Simón Méndez-Ferrer +3 more
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Current Opinion in Hematology, 2018
Purpose of review Hematopoietic stem cells (HSCs) produce mature blood cells throughout lifetime. Natural genetic diversity offers an important yet largely untapped reservoir for deciphering regulatory mechanisms of HSCs and hematopoiesis.
Ying Liang, Cuiping Zhang
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Purpose of review Hematopoietic stem cells (HSCs) produce mature blood cells throughout lifetime. Natural genetic diversity offers an important yet largely untapped reservoir for deciphering regulatory mechanisms of HSCs and hematopoiesis.
Ying Liang, Cuiping Zhang
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Experimental Cell Research, 2014
miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors.
Seka Lazare +3 more
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miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors.
Seka Lazare +3 more
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Clinica Chimica Acta, 2007
Originally discovered in the 1930s, tachykinins have been a subject of renewed interest. Antagonists to the tachykinin receptors have shown potential in the treatment of a variety of maladies including neurodegenerative disorders, heart disease, pain perception and malignancies.
Katherine Liu +4 more
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Originally discovered in the 1930s, tachykinins have been a subject of renewed interest. Antagonists to the tachykinin receptors have shown potential in the treatment of a variety of maladies including neurodegenerative disorders, heart disease, pain perception and malignancies.
Katherine Liu +4 more
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International Reviews of Immunology, 1998
Hematopoiesis is the process by which mature, functional progeny of the eight major lineages of blood cells are produced from a hierarchy of progressively less mature progenitor and stem cells. The control of hematopoiesis involves intimate cellular interactions between developing blood cells and stromal elements as well as regulation by soluble ...
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Hematopoiesis is the process by which mature, functional progeny of the eight major lineages of blood cells are produced from a hierarchy of progressively less mature progenitor and stem cells. The control of hematopoiesis involves intimate cellular interactions between developing blood cells and stromal elements as well as regulation by soluble ...
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Critical Reviews™ in Immunology, 1998
Hematopoiesis is a developmental process that evolves throughout the lifespan of an individual. Most work in the field has focused on events occurring in the adult bone marrow (BM). In the embryo, blood and endothelial cell generation begins very early after gastrulation, in defined intraembryonic mesodermic sites.
Morales-Alcelay, S. +6 more
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Hematopoiesis is a developmental process that evolves throughout the lifespan of an individual. Most work in the field has focused on events occurring in the adult bone marrow (BM). In the embryo, blood and endothelial cell generation begins very early after gastrulation, in defined intraembryonic mesodermic sites.
Morales-Alcelay, S. +6 more
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Current Opinion in Hematology, 2008
Understanding the regulation of hematopoiesis is important for enhanced efficacy of hematopoietic stem and progenitor cell transplantation. Chemokines influence migration, survival, and other actions of hematopoietic stem and progenitor cells. This article summarizes recent progress in understanding the production and actions of chemokines and ...
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Understanding the regulation of hematopoiesis is important for enhanced efficacy of hematopoietic stem and progenitor cell transplantation. Chemokines influence migration, survival, and other actions of hematopoietic stem and progenitor cells. This article summarizes recent progress in understanding the production and actions of chemokines and ...
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Paratracheal Extramedullary Hematopoiesis
International Journal of Hematology, 2001Extramedullary hematopoiesis (EMH) is a rare finding in hematology. A 73-year-old female patient with a 1-week history of severe progressive dyspnea was examined, and computed tomography (CT) showed a paratracheal mass 3 cm in size located 1 cm below the vocals cords and causing obliteration of the tracheal airway.
Ozbilgin, MK +3 more
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Clonal Hematopoiesis and Atherosclerosis
New England Journal of Medicine, 2017Jaiswal et al. report the results of four case–control studies that confirm a near doubling in the risk of coronary heart disease in patients with CHIP,1 a finding that was first reported in the Journal in 2014.2 The authors postulate that two mechanisms may be involved: the promotion of inflammatory responses, as supported in a study involving Tet2 ...
Siddhartha Jaiswal +2 more
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