Results 281 to 290 of about 155,178 (360)

Clonal Hematopoiesis and Solid Cancers. [PDF]

Cancer Sci
Nguyen YTM, Fujisawa M, Ishikawa S, Sakata-Yanagimoto M.   +3 more
europepmc   +1 more source

Enhancing Spatial Transcriptomics via Spatially Constrained Matrix Decomposition with EDGES

Advanced Science, EarlyView.
Imaging‐based spatial transcriptomics technologies are currently limited by their restricted gene detection capacity and low measurement accuracy. Moreover, the insufficient integration of spatial context and single‐cell reference data poses a significant challenge for comprehensive data analysis.
Jinyue Zhao, Jiating Yu, Yuqing Cao, Fan Yuan, Ling‐Yun Wu, Duanchen Sun   +5 more
wiley   +1 more source

Metformin modulates mitochondrial metabolism and epigenetic dysregulation in DNMT3A-mutated clones. [PDF]

Mol Biomed
Hu X, Wang B, Zhang L.
europepmc   +1 more source

Therapy‐Induced ECM Remodeling Creates a Transient Immune Barrier in Residual Melanoma

Advanced Science, EarlyView.
BRAF/MEK inhibition promotes extracellular matrix (ECM) accumulation and remodeling during therapy‐tolerant residual disease, limiting CD8⁺ T cell access to tumor cells. Targeting ECM accumulation restores CD8⁺ T cell infiltration, enhances their intratumoral distribution, and delays therapeutic resistance.
Chia‐Hsin Hsu, Jingyi Chen, Keng‐Jung Lee, Leanne R. Donahue, Danielle Kacaj, Sean P. McDonough, Andrew C. White   +6 more
wiley   +1 more source

Association between clonal hematopoiesis and periodontitis: a two-sample mendelian randomization study. [PDF]

Sci Rep
Qiu F, Shao W, Qin X, Xu R, Lu H.
europepmc   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

Developmental stage and cellular context determine oncogenic and molecular outcomes of <i>Ezh2</i> ^Y641F mutation in hematopoiesis. [PDF]

Blood Neoplasia
Zimmerman SM, Procasky SJ, Smith SR, Liu JY, Torrice C, Souroullas GP.   +5 more
europepmc   +1 more source

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

Advanced Science, EarlyView.
This review summarizes recent advances in the spatiotemporal dynamics of the tumor microenvironment (TME). It highlights the roles of diverse immune and stromal cell populations, spatial architecture of the TME, as well as the gut and tumor microbiota in influencing responses to immune checkpoint inhibitors (ICIs), by integrating insights from single ...
Yuanyuan Zhang, Zhihua Liu
wiley   +1 more source