Results 91 to 100 of about 461,308 (260)
American Journal of Hematology, EarlyView.ABSTRACT Asparaginase is an integral component of therapy for pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma. The success of asparaginase‐containing regimens has led to trials of pediatric/pediatric‐inspired regimens incorporating asparaginase for treating adolescent and young adult (AYA) and adult populations with acute ...
Ibrahim Aldoss +7 more
wiley +1 more source
CD30 as a Target Molecule in the Diagnosis and Therapy of Lymphomas
American Journal of Hematology, EarlyView.ABSTRACT The tumor necrosis factor (TNF)‐receptor superfamily 8 receptor CD30 molecule is expressed in all tumor cells of Hodgkin lymphoma and anaplastic large cell lymphoma but is only weakly expressed in a small subset of large lymphoid cells in normal peripheral lymphoid tissues.
Harald Stein, Brunangelo Falini
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DNA Methylation Episignature as a Novel Diagnostic Tool for Diamond‐Blackfan Anemia Syndrome
American Journal of Hematology, EarlyView.Diamond‐Blackfan Anemia Syndrome (DBAS) is a congenital bone marrow failure disorder characterized by defective erythropoiesis and a spectrum of congenital anomalies, including craniofacial malformations, limb abnormalities, and cardiac and renal defects.
Paola Quarello +29 more
wiley +1 more source
American Journal of Hematology, EarlyView.This multicentric retrospective study evaluated the efficacy of gilteritinib in a cohort of 171 adult patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) harboring a FLT3 mutation, who had previously received at least two lines of therapy. Notably, 26% of the patients had received three or more prior lines of treatment. The analysis of
Matteo Molica +41 more
wiley +1 more source
Research advancements and evaluation of multifactor‐induced murine models for gastric cancer
Animal Models and Experimental Medicine, EarlyView.Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang +5 more
wiley +1 more source
The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast
Animal Models and Experimental Medicine, EarlyView.The flow diagram outlines the chemical induction of breast tumors through a single intraperitoneal dose of MNU. Tumor development was assessed using ultrasound and clinical examination. After 14 weeks, mammary tissue was collected and histologically analyzed to evaluate structural similarities between sows and humans, the carcinogenic potential of MNU,
Claudia Elizabeth Vera‐Tizatl +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Current radiation medical countermeasures primarily focus on hematopoietic acute radiation syndrome (H‐ARS) using agents like granulocyte colony‐stimulating factor (G‐CSF), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), and romiplostim, alongside treatments for internal contamination (Prussian blue, diethylenetriamine pentaacetate [DTPA ...
Wen‐Bing Ma +12 more
wiley +1 more source
Targeting the Spleen as an Alternative Site for Hematopoiesis [PDF]
, 2019 Lim, Hong +3 more
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Macrophage polarization impacts tunneling nanotube formation and intercellular organelle trafficking. [PDF]
, 2019 Tunneling nanotubes (TNTs) are cellular extensions enabling cytosol-to-cytosol intercellular interaction between numerous cell types including macrophages.
Cherqui, Stephanie +4 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry +13 more
wiley +1 more source