Results 131 to 140 of about 540,232 (408)

The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

Journal of Hematology & Oncology, 2016
Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy
K. Zhao, Qi-fa Liu
semanticscholar   +1 more source

Hematopoietic progenitor cell content of vertebral body marrow used for combined solid organ and bone marrow transplantation [PDF]

, 1995
While cadaveric vertebral bodies (VB) have long been proposed as a suitable source of bone marrow (BM) for transplantation (BMT), they have rarely been used for this purpose. We have infused VB BM immediately following whole organ (WO) transplantation to
Ball, ED, Fontes, PA, Rao, AS, Ricordi, C, Rybka, WB, Starzl, TE, Winkelstein, A   +6 more
core   +1 more source

A Phase II Trial of Geriatric Assessment‐Guided Selection of Treatment Intensity in Older Adults With AML

American Journal of Hematology, EarlyView.
ABSTRACT How to select the appropriate intensity of chemotherapy in older adults with acute myeloid leukemia (AML) remains an unanswered question. In a phase II trial of older adults ≥ 60 years with AML (n = 73), we used geriatric assessment (measures of comorbidity burden, physical and cognitive function) to determine fitness for intensive ...
Vijaya R. Bhatt, Christopher S. Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Michael Haddadin, Ann M. Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu   +10 more
wiley   +1 more source

T-cell alloreactivity in hematopoietic stem cell transplantation

Biology of Blood and Marrow Transplantation, 2005
Graft-versus-host disease (GVHD), lymphopenia, nd immune deficiency are major complications of llogeneic hematopoietic stem cell transplantation and re causes of morbidity and mortality [1,2]. Immune uppression (IS) therapy administered for control of VHD, injury to the thymus occurring during conitioning and GVHD, and decreased thymus-depenent ...
openaire   +3 more sources

Classical and Late‐Onset SOS/VOD After Allogeneic HSCT: A Japanese Transplant Registry Analysis

American Journal of Hematology, EarlyView.
ABSTRACT Sinusoidal obstruction syndrome/veno‐occlusive disease (SOS/VOD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). According to the 2016 European Society for Blood and Marrow Transplantation criteria, SOS/VOD is classified into classical SOS/VOD and late‐onset SOS/VOD, but their similarities and ...
Kyoko Masuda, Keisuke Kataoka, Masatoshi Sakurai, Yuho Najima, Naonori Harada, Shoko Ukita, Naoyuki Uchida, Noriko Doki, Takahiro Fukuda, Masatsugu Tanaka, Hiroyuki Ohigashi, Jun Ishikawa, Satoshi Yoshihara, Masashi Sawa, Shuichi Ota, Yoshinobu Kanda, Tetsuya Nishida, Makoto Onizuka, Yoshiko Atsuta, Hideki Nakasone, Kimikazu Yakushijin   +20 more
wiley   +1 more source

Towards an understanding of lineage specification in hematopoietic stem cells: A mathematical model for the interaction of transcription factors GATA-1 and PU.1 [PDF]

arXiv, 2006
In addition to their self-renewal capabilities, hematopoietic stem cells guarantee the continuous supply of fully differentiated, functional cells of various types in the peripheral blood. The process which controls differentiation into the different lineages of the hematopoietic system (erythroid, myeloid, lymphoid) is referred to as lineage ...
arxiv  

Somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.

Journal of Clinical Oncology, 2014
PURPOSE Recurrently mutated genes in myelodysplastic syndrome (MDS) are pathogenic drivers and powerfully associated with clinical phenotype and prognosis.
R. Bejar, K. Stevenson, B. Caughey, R. C. Lindsley, B. Mar, P. Stojanov, G. Getz, D. Steensma, J. Ritz, R. Soiffer, J. Antin, E. Alyea, P. Armand, V. Ho, J. Koreth, D. Neuberg, C. Cutler, B. Ebert   +17 more
semanticscholar   +1 more source

Role of PTH in Bone Marrow Niche and HSC Regulation [PDF]

, 2017
Purpose of Review. The bone marrow microenvironment hosts a multicellular complex that is extraordinary in its interdependence and function. The composite machinery within the axial and long bones is involved in the homing, maintenance, differentiation ...
Agas, Dimitrios, Censi, Roberta, Lacava, Giovanna, Marchetti, Luigi, Sabbieti, Maria Giovanna   +4 more
core   +1 more source

Clinical Impact of Graft Cryopreservation on Allogeneic Stem Cell Transplantation: An Italian, Registry‐Based Study on Behalf of the “Gruppo Italiano Per Il Trapianto di Midollo Osseo, Cellule Staminali Emopoietiche e Terapia Cellulare” (GITMO)

American Journal of Hematology, EarlyView.
ABSTRACT The coronavirus disease 2019 (COVID‐19) pandemic created major challenges for allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Scientific societies and authorities recommended cryopreserving grafts before starting conditioning regimens, despite limited data on the clinical impact.
Irene Defrancesco, Virginia Valeria Ferretti, Patrizia Chiusolo, Domenico Russo, Chiara Nozzoli, Attilio Olivieri, Massimiliano Gambella, Irene Maria Cavattoni, Stefania Bramanti, Stella Santarone, Renato Fanin, Roberto Cairoli, Simona Piemontese, Matteo Parma, Francesco Onida, Alessandro Busca, Luca Castagna, Angela Cuoghi, Domenico Pastore, Nicola Mordini, Fabio Benedetti, Cristina Skert, Carlo Borghero, Anna Paola Iori, Franca Fagioli, Vincenzo Pavone, Carmine Selleri, Simone Cesaro, Maurizio Musso, Marco Ladetto, Daniele Vallisa, Paola Carluccio, Alessandra Picardi, Monica Tozzi, Alessandra Biffi, Giuseppe Milone, Maura Faraci, Arcangelo Prete, Lucia Prezioso, Antonio Maria Risitano, Francesco Paolo Tambaro, Veronica Tintori, Piero Galieni, Fabrizio Pane, Caterina Zerbi, Antonio Bianchessi, Giulia Losi, Francesco Romano, Alessia Taurino, Elena Oldani, Nicola Polverelli, Francesca Bonifazi, Massimo Martino   +52 more
wiley   +1 more source

Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation [PDF]

, 2012
Chronic graft-versus-host disease (cGVHD) is a complication after minor antigen mismatched bone marrow transplantation (BMT) characterized by an autoimmune-type reaction in various organs.
Hideyuki Okano, Kazuo Tsubota, Sadafumi Suzuki, Saori Yaguchi, Satoru Morikawa, Shigeto Shimmura, Shinichiro Okamoto, Takaaki Inaba, Tomonori Yaguchi, Yo Mabuchi, Yoko Ogawa, Yumi Matsuzaki, Yutaka Kawakami   +12 more
core   +1 more source