Results 81 to 90 of about 461,308 (260)
Advanced Science, EarlyView.This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu +11 more
wiley +1 more source
Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing
Advanced Science, EarlyView.Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley +1 more source
Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy
Advanced Science, EarlyView.This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li +5 more
wiley +1 more source
Advanced Science, EarlyView.Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng * +7 more
wiley +1 more source
Advanced Science, EarlyView.The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee +28 more
wiley +1 more source
Identifying Key Questions and Challenges in Microchimerism Biology
Advanced Science, EarlyView.This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua +31 more
wiley +1 more source
Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool. [PDF]
, 2008 Mesenchymal stem cells (MSCs) from adult somatic tissues may differentiate in vitro and in vivo into multiple mesodermal tissues including bone, cartilage, adipose tissue, tendon, ligament or even muscle. MSCs preferentially home to damaged tissues where
García-Castro, J +5 more
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Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies
Advanced Science, EarlyView.This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang +7 more
wiley +1 more source
The Immune Microenvironment in Liver Cancer: From Analysis to Targeting
Advanced Science, EarlyView.This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan +5 more
wiley +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Survival outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) have improved with modern frontline therapies and minimal residual disease (MRD)‐guided strategies. As a result, allogeneic hematopoietic cell transplantation (HCT) is increasingly deferred in first remission (CR1) and used in the relapsed setting.
Oren Pasvolsky +24 more
wiley +1 more source