Results 121 to 130 of about 394,042 (312)
Frontiers in OncologyIntroductionNuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression.
Jie Yuan +15 more
doaj +1 more source
Haematologica, 2009 Background Hematopoietic stem and progenitor cells can interact with their microenvironment via integrins which are adhesion receptors consisting of α and β subunits.
Thomas D. Schreiber +7 more
doaj +1 more source
Generation of Human Epidermis-Derived Mesenchymal Stem Cell-like Pluripotent Cells and their reprogramming in mouse chimeras [PDF]
, 2011 Stem cells can be derived from the embryo (embryonic stem cells, ESCs), from adult tissues (adult stem cells, ASCs), and by induction of fibroblasts (induced pluripotent stem cells, iPSs).
Bing Huang +21 more
core +1 more source
Advanced Science, EarlyView.Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen +11 more
wiley +1 more source
Global Asymptotic Stability and Hopf Bifurcation for a Blood Cell Production Model [PDF]
Mathematical Biosciences and Engineering 3, 2 (2006) 325-346, 2009 We analyze the asymptotic stability of a nonlinear system of two differential equations with delay describing the dynamics of blood cell production. This process takes place in the bone marrow where stem cells differentiate throughout divisions in blood cells.
arxiv
ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells
Haematologica, 2015 Successful expansion of hematopoietic stem cells would benefit the use of hematopoietic stem cell transplants in the clinic. Several angiopoietin-like proteins, including angiopoietin-like 7, can support the activity of hematopoietic stem cells. However,
Yiren Xiao +20 more
doaj +1 more source
Sowing the Seeds of a Fruitful Harvest: Hematopoietic Stem Cell Mobilization [PDF]
, 2013 Hematopoietic stem cell transplantation is the only curative option for a number of malignant and non-malignant diseases. As the use of hematopoietic transplant has expanded, so too has the source of stem and progenitor cells.
Hoggatt, Jonathan +2 more
core +1 more source
Advanced Science, EarlyView.Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang +10 more
wiley +1 more source
A stem-cell ageing hypothesis on the origin of Parkinson's disease [PDF]
arXiv, 2010 A transcriptome-wide blood expression dataset of Parkinson's disease (PD) patients and controls was analyzed under the hypothesis-rich mathematical framework. The analysis pointed towards differential expression in blood cells in many of the processes known or predicted to be disrupted in PD.
arxiv