Results 121 to 130 of about 1,175,170 (409)

Target Enrichment Metagenomics Reveals Human Pegivirus-1 in Pediatric Hematopoietic Stem Cell Transplantation Recipients [PDF]

, 2022
Natali Ludowyke, Worakorn Phumiphanjarphak, Nopporn Apiwattanakul, Suwimon Manopwisedjaroen, Samart Pakakasama, Insee Sensorn, Ekawat Pasomsub, Wasun Chantratita, Suradej Hongeng, Pakorn Aiewsakun, Arunee Thitithanyanont   +10 more
openalex   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

A dual origin for Bcr-Abl gene translocation/fusion as dynamics of synergism of the hematopoietic stem cell and hemangioblast in chronic myeloid leukemia [PDF]

, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core   +1 more source

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism

Communications Biology
Chronic alcohol consumption can lead to alcohol live disease (ALD). Steatosis is a critical hallmark of ALD, making it an important stage for therapeutic intervention.
Mingzhu Jiang, Ying Feng, Jingxian Wang, Xiang Xu, Zegan Liu, Tongfei Li, Shinan Ma, Yufeng Wang, Xingrong Guo, Shiming Du   +9 more
doaj   +1 more source

Interlukin-4 weakens resistance to stress injury and megakaryocytic differentiation of hematopoietic stem cells by inhibiting Psmd13 expression [PDF]

, 2023
Ai Gao, Xu ShuHui, Qing Li, Caiying Zhu, Fengjiao Wang, Yajie Wang, Sha Hao, Fang Dong, Hui Cheng, Tao Cheng, Yuemin Gong   +10 more
openalex   +1 more source

Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis. [PDF]

, 2015
During embryonic development, hematopoietic cells develop by a process of endothelial-to hematopoietic transition of a specialized population of endothelial cells. These hemogenic endothelium (HE) cells in turn develop from a primitive population of FLK1(
Göttgens, Berthold, Knezevic, Kathy, Kouskoff, Valerie, Lacaud, Georges, Nasrallah, Rabab, Pimanda, John E, Thai, Thuan, Thomas, Shane R   +7 more
core   +5 more sources

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

P121 | A VALID PREDICTIVE APPROACH IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: COMBINATION OF MULTIGENE PROFILING AND HIGH-SENSITIVITY MINIMAL RESIDUAL DISEASE ASSESSMENT

Haematologica
The correlation between the genetic heterogeneity of CLL and clinical diversity still remains unclear, although Next Generation Sequencing (NGS) approaches have contributed to the improvement of such knowledge.
E. Borotti, E. Ronda, A. Scarpa, V. Scaglia, A. Arcari, L. Morello, A. Rossi, D. Vallisa   +7 more
doaj  

ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation

Journal of Lipid Research
Liver injury is closely related to poor outcomes in sepsis patients. Current studies indicate that sepsis is accompanied by metabolic disorders, especially those related to lipid metabolism.
Ying Feng, Shan Luo, Chen Fang, Shinan Ma, Dandan Fan, Yanghui Chen, Zhuo Chen, Xiang Zheng, Yijun Tang, Xiaobei Duan, Xingling Liu, Xuzhi Ruan, Xingrong Guo   +12 more
doaj   +1 more source