Results 11 to 20 of about 5,158,360 (311)

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
Dembowsky, K., Dembowsky, Klaus, Romagnoli, B., G Spohn, Karpova, Darja, Patel, K., Chevalier, E., Levesque, J. P., E Chevalier, D Karpova, Patel, Kalpana, Spohn, Gabriele, Romagnoli, Barbara, Schulz, M., Wiercinska, Eliza, Chevalier, Eric, H Bonig, K Dauber, E Wiercinska, J P Levesque, Schulz, Miriam, Chudziak, D., K Dembowsky, Dauber, Katrin, Karpova, D., B Romagnoli, A R Pettit, Wiercinska, E., D Chudziak, Levesque, Jean-Pierre, Bönig, Halvard-Björn, Spohn, G., Pettit, Allison R., M Schulz, K Patel, Bonig, H., Pettit, A. R., Chudziak, Doreen, Dauber, K.   +38 more
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Identification of the niche and phenotype of the first human hematopoietic stem cells [PDF]

, 2014
In various vertebrate species, the dorsal aorta (Ao) is the site of specification of adult hematopoietic stem cells (HSCs). It has been observed that the upregulation of essential hematopoietic transcription factors and the formation of specific intra ...
Stanislav Rybtsov, Anderson, Richard A., Turner, Marc L., Anderson, Richard A, Ivanovs, Andrejs, Andrejs Ivanovs, Richard A. Anderson, Turner, Marc L, Marc L. Turner, Alexander Medvinsky, Medvinsky, Alexander, Rybtsov, Stanislav   +11 more
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Generation and characterization of erythroid cells from human embryonic stem cells and induced pluripotent stem cells : an overview [PDF]

, 2011
Because of the imbalance in the supply and demand of red blood cells (RBCs), especially for alloimmunized patients or patients with rare blood phenotypes, extensive research has been done to generate therapeutic quantities of mature RBCs from ...
Bönig, Halvard-Björn, Chang, Kai-Hsin, Kai-Hsin Chang, Thalia Papayannopoulou, Halvard Bonig, Papayannopoulou, Thalia   +5 more
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Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny [PDF]

, 2012
The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology.
Calaminus, Simon, Watson, Steve P., Tessa L. Holyoake, Guitart, Amelie V., Amelie V Guitart, Calaminus, Simon D J, Machesky, Laura, Schachtner, Hannah, Steve P Watson, Amelie V. Guitart, Amy Sinclair, Amelie Guitart, Kranc, Kamil R., Machesky, Laura M, Holyoake, Tessa L., Holyoake, Tessa L, Calaminus, Simon D.J., Steve P. Watson, Watson, Steve P, Guitart, Amelie, Machesky, Laura M., Simon D J Calaminus, Kranc, Kamil R, Watson, Steve, Laura M. Machesky, Holyoake, Tessa, Sinclair, Amy, Hannah Schachtner, Simon D. J. Calaminus, Laura M Machesky, Guitart, Amelie, V, Tessa L Holyoake, Kranc, Kamil, Kamil R. Kranc, Kamil R Kranc   +34 more
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Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients [PDF]

, 2013
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients
Lehrnbecher, Thomas, Thomas eLehrnbecher, Schmidt, Stanislaw, Thomas eKlingebiel, Tramsen, Lars, Lars eTramsen, Klingebiel, Thomas, Stanislaw eSchmidt   +7 more
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Stem Cell Antigen CD34 In Native And Engineered Form Alter Its Binding Ability To Stromal Cells And Ligands: A Classical Example Of Clinical Benefits Of Therapeutic Genetic Engineering Of Stem Cells In Transplantation [PDF]

, 2010
CD34 is a highly glycosylated surface-expressed sialomucin and, because it is present on hematopoietic stem cells (HSCs), has demonstrated immense clinical utility in their enumeration in aphaeresis products, immunoaffinity purification for ...
Yogesh Kumar Verma, Pallavi Gupta, Vimal Kumar Singh, Neeraj Kumar Satija, Rajendra Prasad Tripathi, Pallavi Gupta, Gurudutta Gangenahalli, Vimal Kumar Singh, Rajendra Prasad Tripathi   +8 more
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Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
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Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Biomarker Research, 2020
Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expression in
Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias   +10 more
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Virus-Specific T Cells: Promising Adoptive T Cell Therapy Against Infectious Diseases Following Hematopoietic Stem Cell Transplantation [PDF]

Advanced Pharmaceutical Bulletin, 2023
Hematopoietic stem cell transplantation (HSCT) is a life-saving therapy for various hematologic disorders. Due to the bone marrow suppression and its long recovery period, secondary infections, like cytomegalovirus (CMV), Epstein-Bar virus (EBV), and ...
Arsalan Jalili, Abbas Hajifathali, Mozhdeh Mohammadian, Ghazaleh Sankanian, Maryam Sayahinouri, Mahmoud Dehghani Ghorbi, Elham Roshandel, Nasser Aghdami   +7 more
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Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1 [PDF]

, 2007
Background: AML1/RUNX1 is the most frequently mutated gene in leukaemia and is central to the normal biology of hematopoietic stem and progenitor cells. However, the role of different AML1 isoforms within these primitive compartments is unclear.
Hong, DL, Shinobu Tsuzuki, Tsuzuki, S, Dengli Hong, Enver Tariq, Tsuzuki Shinobu, Matsuo Keitaro, Keitaro Matsuo, Tariq Enver, Hong Dengli, Seto Masao, Rajeev Gupta, Matsuo, K, Gupta Rajeev, Gupta, R, Seto, M, Hong, D, Enver, T, Masao Seto   +18 more
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