Results 21 to 30 of about 1,207,844 (359)

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Biomarker Research, 2020
Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expression in
Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias   +10 more
doaj   +1 more source

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

Nature Communications, 2021
Preclinical molecular models are useful that mimic a patient´s response to targeted therapy. Here, the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft models of acute leukemia to identify individual
Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Anja Arner, Daniela Senft, Vindi Jurinovic, Wen-Hsin Liu, Yuqiao Gao, Veronika Dill, Boris Fehse, Claudia D. Baldus, Lorenz Bastian, Lennart Lenk, Denis M. Schewe, Johannes W. Bagnoli, Binje Vick, Jan Philipp Schmid, Alexander Wilhelm, Rolf Marschalek, Philipp J. Jost, Cornelius Miething, Kristoffer Riecken, Marc Schmidt-Supprian, Vera Binder, Irmela Jeremias   +26 more
doaj   +1 more source

p53 mediates failure of human definitive hematopoiesis in dyskeratosis congenita [PDF]

, 2017
Summary: Dyskeratosis congenita (DC) is a bone marrow failure syndrome associated with telomere dysfunction. The progression and molecular determinants of hematopoietic failure in DC remain poorly understood.
Batista, Luis Francisco Zirnberger, Brenner, Kirsten Ann, Dege, Carissa, Fok, Wilson Chun, Niero, Evandro Luis de Oliveira, Sturgeon, Christopher Michael   +5 more
core   +3 more sources

The hematopoietic stem cell niche [PDF]

Frontiers in Bioscience, 2012
Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC
Park, Dongsu, Sykes, David, Scadden, David   +2 more
openaire   +2 more sources

Autophagy maintains the metabolism and function of young and old (hematopoietic) stem cells

Nature, 2017
With age, haematopoietic stem cells lose their ability to regenerate the blood system, and promote disease development. Autophagy is associated with health and longevity, and is critical for protecting haematopoietic stem cells from metabolic stress ...
Theodore T. Ho, M. Warr, Emmalee R Adelman, Olivia M Lansinger, J. Flach, E. Verovskaya, M. Figueroa, E. Passegué   +7 more
semanticscholar   +1 more source

Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo [PDF]

, 2017
Human umbilical cord blood (CB) has attracted much attention as a reservoir for functional hematopoietic stem and progenitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs). Previously, we demonstrated that bone marrow stromal cell (
Biondi, Andrea, Corsi, Alessandro, Donsante, Samantha, Pievani, Alice, Rambaldi, Benedetta, Remoli, Cristina, Riminucci, Mara, Robey, Pamela G., Sacchetti, Benedetto, Scagliotti, Valeria, Serafini, Marta, Vergani, Patrizia   +11 more
core   +2 more sources

The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications

Stem cell research & therapeutics, 2019
Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell microenvironment provides factors and elements that play significant roles in controlling the cell fate direction.
Pan Zhang, Chen Zhang, Jing Li, Jiyang Han, Xiru Liu, Hui Yang   +5 more
semanticscholar   +1 more source

Association of Interleukin 10 (IL-10) Gene Polymorphism (819T > C) with Susceptibility to Acute Myeloid Leukemia: A Meta-Analysis

Iranian Journal of Public Health, 2022
Background: Studies reported an association between interleukin (IL)-10 -819T>C polymorphism and the risk of developing Acute myeloid leukemia (AML), however due to inconsistency among these results, relationship between IL-10 -819T>C polymorphism and ...
Hamid Reza Ahadi, Amin Ebrahimi Sadrabadi, Arsalan Jalili, Abbas Hajifathali   +3 more
doaj   +1 more source

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

Adverse stem cell clones within a single patient’s tumor predict clinical outcome in AML patients

Journal of Hematology & Oncology, 2022
Acute myeloid leukemia (AML) patients suffer dismal prognosis upon treatment resistance. To study functional heterogeneity of resistance, we generated serially transplantable patient-derived xenograft (PDX) models from one patient with AML and twelve ...
Christina Zeller, Daniel Richter, Vindi Jurinovic, Ilse A. Valtierra-Gutiérrez, Ashok Kumar Jayavelu, Matthias Mann, Johannes W. Bagnoli, Ines Hellmann, Tobias Herold, Wolfgang Enard, Binje Vick, Irmela Jeremias   +11 more
doaj   +1 more source