Results 21 to 30 of about 224,203 (310)
Adverse stem cell clones within a single patient’s tumor predict clinical outcome in AML patients
Journal of Hematology & Oncology, 2022 Acute myeloid leukemia (AML) patients suffer dismal prognosis upon treatment resistance. To study functional heterogeneity of resistance, we generated serially transplantable patient-derived xenograft (PDX) models from one patient with AML and twelve ...
Christina Zeller +11 more
doaj +1 more source
EMBO Molecular Medicine, 2022 Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in children, and relapse/refractory (r/r) disease is difficult to treat, both in children and adults.
Michela Carlet +18 more
doaj +1 more source
The hematopoietic stem cell diet [PDF]
International Journal of Hematology, 2018 Hematopoietic stem cells (HSCs) are responsible for sustaining life-long blood formation or hematopoiesis and are also used clinically in a form of bone marrow transplantation, a curative cellular therapy for a range of hematological diseases. HSCs are maintained throughout adult life by a complex biological niche or microenvironment, which is thought ...
Adam C, Wilkinson, Satoshi, Yamazaki
openaire +2 more sources
The hematopoietic stem cell niche [PDF]
Frontiers in Bioscience, 2012 Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC
Park, Dongsu +2 more
openaire +3 more sources
Skeletal muscle is enriched in hematopoietic stem cells and not inflammatory cells in cachectic mice
, 2008 OBJECTIVE: Cachexia, a debilitating syndrome characterized by skeletal muscle wasting, is associated to many chronic diseases and diminishes the quality of life and survival of patients. Tumor-derived factors and proinflammatory cytokines, including TNF-
Angelica Toschi +14 more
core +1 more source
Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]
, 2004 Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Seliger, Christian +15 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Characterization of aging-related changes in human hematopoietic stem cells
, 2021 The continuous production of blood cells, maintained by hematopoietic stem cells, is vital to sustain life. With advancing age, hematopoietic stem cells undergo distinct age-related modifications that manifest as an increased risk of developing blood ...
Amoah, Amanda
core +1 more source
Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury
Frontiers in Bioengineering and Biotechnology, 2022 As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury.
Jianqi Xue +25 more
doaj +1 more source