Results 101 to 110 of about 1,502 (157)
Some of the next articles are maybe not open access.
The main photosensitizing components of hematoporphyrin derivative
Cancer Letters, 1982Commercial hematoporphyrin (Hp) and the tumor-localizing and photosensitizing agent hematoporphyrin derivative (Hpd) were analysed by means of high pressure lipid chromatography (HPLC). Furthermore, their efficiencies in sensitizing the photoinactivation of human cells in vitro were compared. The comparison showed that the least polar components of Hpd
J, Moan, T, Christensen, S, Sommer
openaire +2 more sources
The Analysis of Hematoporphyrin Derivative
1983When work on photoradiation therapy (PRT) commenced in Adelaide, the stringency of Australian Federal drug regulations made it preferable for us to prepare HPD rather than import the product. It was therefore important that we have an acceptable assay for both HPD solid and HPD clinical1, thereby enabling comparisons between our material and the ...
P A, Cadby +4 more
openaire +2 more sources
Photochemotherapy mediated by hematoporphyrin derivative in gastroenterology
European Journal of Cancer and Clinical Oncology, 1987While results concerning photodynamic treatments of cancers in pneumology or dermatology have been published regularly, few works have been devoted to gastroenterology. Twenty-seven non-operable patients bearing various G.I. tumors of less than 40 mm dia.
T, Patrice +6 more
openaire +2 more sources
Hematoporphyrin derivative for detection and management of cancer
Cancer, 1967Hematoporphyrin derivative has been evaluated as a means of detecting malignancy in 121 patients suspected of having cancer. Areas examined included the cervix, vagina, tracheobronchial tree, esophagus, peritoneum and rectum. Dysplastic and neoplastic tissue was identified by red fluorescence whereas nonneoplastic tissue appeared grayish white to black.
R L, Lipson, E J, Baldes, M J, Gray
openaire +2 more sources
Hematoporphyrin Derivative Photoradiation Therapy
Archives of Ophthalmology, 1984To the Editor. —I read with interest the article in the JulyArchivesregarding hematoporphyrin derivatives in photoradiation therapy. 1 I found a number of references to this subject appearing in the literature. When I introduced porphyrins to clinical medicine in 1955, at the Johns Hopkins Hospital, Baltimore, 2 I originally used it as a surgical tool.
openaire +3 more sources
Hematoporphyrin and hematoporphyrin-derivative photosensitization of mitochondria
Biochimie, 1986Laser micro-irradiation experiments show that mitochondria are profoundly affected when cells are irradiated with Hp as the photosensitizer. Functional as well as enzymatic studies on isolated mitochondria show that coupling between respiration and oxidative phosphorylation, Ca2+ transport and respiration are successively lost under irradiation in the ...
openaire +2 more sources
Cell biology of hematoporphyrin derivative (hpd)
Lasers in Surgery and Medicine, 1983AbstractTissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) HPD uptake, (2) HPD washout, and (3) fluorescence changes. The absorption peaks were the same for HPD in solution and HPD bound to cells. HPD was taken up by all cell types rapidly within the first 10 hours of exposure, and leveled off by 20 hours of ...
Michael W. Berns +5 more
openaire +2 more sources
Photophysics and Photochemistry of Hematoporphyrin, Hematoporphyrin Derivative and Uroporphyrin I
1985The putative action mechanism in photodynamic therapy (PDT) involves serum transport of HPD to tumor tissue, localization and retention of the active constituent, generation of singlet molecular oxygen (Δ) by the action of visible light and the attack of t on the cellular targets.
L I, Grossweiner, A, Blum, G C, Goyal
openaire +2 more sources
THE STRUCTURE OF THE ACTIVE MATERIAL IN HEMATOPORPHYRIN DERIVATIVE
Photochemistry and Photobiology, 1987Abstract The structure of the active material in hematoporphyrin derivative is shown to be a condensation polymer of hematoporphyrin linked by ether functional groups. When a mixture of the monoacetates and the diacetate of hematoporphyrin is treated with dilute sodium hydroxide solution a polymeric fraction is formed which constitutes the active ...
C J, Byrne, L V, Marshallsay, A D, Ward
openaire +2 more sources
Hematoporphyrin derivatives: An oligomeric composition study
Journal of Photochemistry and Photobiology B: Biology, 1990The oligomeric composition of HpD, Photofrin II and other hematoporphyrin derivatives useful for the diagnosis and therapy of tumors has been studied. Gel chromatographic procedures were used that excluded porphyrin aggregation. Photofrin and hematoporphyrin derivatives were shown to contain different quantities of monomer, dimer and other oligomeric ...
A F, Mironov, A N, Nizhnik, A Y, Nockel
openaire +2 more sources