Results 111 to 120 of about 1,502 (157)

Bronchoscopic Phototherapy Using Hematoporphyrin Derivative

Surgical Clinics of North America, 1984
Phototherapy in the presence of hematoporphyrin (HPD) produces cytotoxicity through both energy- and power-dependent mechanisms. The resulting cellular death demonstrates the promise of HPD in the therapy of small cancers. This article reports our clinical experience and follow-up results of treating 19 patients with cancer of the tracheobronchial tree,
D A, Cortese, J H, Kinsey
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The Photodynamic Properties of a Particular Hematoporphyrin Derivative

Archives of Dermatology, 1960
In 1898 Oscar Raab, while a student in Tappeiner's laboratory, recognized that paramecia were sensitized to light by the aniline dye, acridine. This finding led to extensive studies by Tappeiner and Jodlbauer and their associates,9,19,-21and to the introduction of the term "photodynamic action," used by Tappeiner in 1904. The use of hematoporphyrin in
R L, LIPSON, E J, BALDES
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PHOTOSENSITIZED LYSIS OF LIPOSOMES BY HEMATOPORPHYRIN DERIVATIVE

Photochemistry and Photobiology, 1983
AbstractThe spectral properties and efficiency for photosensitizing the lysis of phosphatidylcholine liposomes have been measured for the components of hematoporphyrin derivative (Hpd) after alkaline hydrolysis and fractionation by polyacrylamidc gel chromatography.
L I, Grossweiner, G C, Goyal
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The Structure of the Active Component of Hematoporphyrin Derivative

1984
Photoradiation therapy (PRT) for local treatment of malignant tumors utilizing hematoporphyrin derivative (Hpd) as photosensitizing drug is undergoing clinical trials in several centers in the U. S. and abroad. This therapy is based on the localization and retention of Hpd in most tumors, as well as its photodynamic action which likely generates ...
T J, Dougherty, W R, Potter, K R, Weishaupt   +2 more
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SITES OF PHOTOSENSITIZATION BY DERIVATIVES OF HEMATOPORPHYRIN

Photochemistry and Photobiology, 1986
AbstractLeukemia L1210 cells were incubatedin vitrowith the tumor‐localizing product HPD (hem‐atoporphyrin derivative) for 0.5. 4 and 18 h. Effects of subsequent irradiation on viability, membrane transport and integrity, DNA synthesis and intracellular ATP concentration were assessed. Intracellular porphyrin pools were analyzed by HPLC.
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Pharmacokinetic Studies of Hematoporphyrin Derivatives on Rat Hepatocytes. Protoporphyrin Dimethyl Ester Hematoporphyrin Ether versus Dihematoporphyrin Ether-Free Hematoporphyrin Derivative

Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both, H, Häberlein, A M, Gressner, I, Sieg, M O, Doss   +4 more
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CHEMISTRY OF HEMATOPORPHYRIN‐DERIVED PHOTOSENSITIZERS

Photochemistry and Photobiology, 1987
Abstract The hematoporphyrin‐derived tumor‐localizing preparation HPD consists of porphyrin monomers, which are‘inactive’(not tumor‐localizing), and a dimer/oligomer fraction which is responsible for the localizing phenomenon. In an organic solvent system, gel‐exclusion chromatography can separate HPD into fractions containing porphyrin monomers ...
David Kessel, Paul Thompson, Brian Musselman, C. K. Chang   +3 more
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Influence of medium polarity on the photosensitizing properties of hematoporphyrin and hematoporphyrin derivative (Photofrin II)

Journal of Photochemistry and Photobiology B: Biology, 1988
The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes.
M, Shopova, T, Gantchev
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PURIFICATION and ANALYSIS OF HEMATOPORPHYRIN and HEMATOPORPHYRIN DERIVATIVE BY GEL EXCLUSION and REVERSE‐PHASE CHROMATOGRAPHY*

Photochemistry and Photobiology, 1987
AbstractA ternary‐solvent HPLC method for analysis of the components of the tumor‐localizing product HPD is described. This HPLC system was used to assess the utility of a new method, based on gel exclusion chromatography, for purification of hematoporphyrin.
D, Kessel, P, Thompson
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Hematoporphyrin‐Derivative and Photoradiation Therapy of Malignant Tumors

Lasers in Surgery and Medicine, 1983
AbstractKodak projectors with #2418 red Corning filters were used as a light source to treat cutaneous and subcutaneous malignancies in five patients who previously had been given hematoporphyrin derivative (HpD). An argon dye laser system was used to treat malignancies in patients who also were given the HpD.
J S, McCaughan, J T, Guy, P, Hawley, W, Hicks, W, Inglis, L, Laufman, E, May, T A, Nims, R, Sherman   +8 more
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