Results 131 to 140 of about 321,886 (190)
Hyperthermal Effects in Phototherapy with Hematoporphyrin Derivative Sensitization
Tumori Journal, 1984 Although the photochemical reaction of hematoporphyrin derivative (HpD) appears to play a major role in cytotoxic activity, the hyperthermal contribution to tumor destruction has not yet been clarified. We investigated its role in the effectiveness of laser photoradiation therapy using MS-2 sarcoma transplanted into the hind pad of BALB/c mice as the ...
E, Melloni +7 more
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Spectroscopic studies of hematoporphyrin-derivative in culture medium
Chemico-Biological Interactions, 1984This work reports on studies of hematoporphyrin-derivative (HpD) behaviour in culture medium. Absorption, excitation and emission spectra, together with time-resolved fluorescence measurements, were performed. In previous works, similar studies had been carried out on HpD in saline and in lymphocytes: a new porphyrin species (NPS) and the environmental
Roberta Ramponi +2 more
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Hematoporphyrin-Derivative and Photoradiation Therapy of Malignant Tumors
Lasers in Surgery and Medicine, 1983AbstractKodak projectors with #2418 red Corning filters were used as a light source to treat cutaneous and subcutaneous malignancies in five patients who previously had been given hematoporphyrin derivative (HpD). An argon dye laser system was used to treat malignancies in patients who also were given the HpD.
J S McCaughan
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Hematoporphyrin derivative for detection and treatment of cancer
Journal of Surgical Oncology, 1980exaly +3 more sources
Zinc hematoporphyrin in preparations of hematoporphyrin and hematoporphyrin derivative
Chemical Physics Letters, 1984Abstract The blue-shifted emission from aged aqueous solutions of hematoporphyrin and its derivatives, reported by others to originate from special aggregates, is shown to originate from the zinc chelates of the porphyrins. Suggestions are made regarding the role of such zinc porphyrins in the localization of hematoporphyrin and its derivatives in ...
A.A. Lamola, M. Sassaroli
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Tumor Fluorescence with Hematoporphyrin Derivative
Annals of Otology, Rhinology & Laryngology, 1977Hematoporphyrin derivative (HpD) is one of several photodynamically active dyes that accumulate in tumor cells and can be used to differentiate neoplastic from normal tissue by violet light activation. Degree of tumor fluorescence was studied in relation to the nature of the hematoporphyrin compound, dose of HpD injected, route of injection, and ...
R J, Carpenter +3 more
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The Analysis of Hematoporphyrin Derivative
1983When work on photoradiation therapy (PRT) commenced in Adelaide, the stringency of Australian Federal drug regulations made it preferable for us to prepare HPD rather than import the product. It was therefore important that we have an acceptable assay for both HPD solid and HPD clinical1, thereby enabling comparisons between our material and the ...
P A, Cadby +4 more
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Hematoporphyrin derivative for detection and management of cancer
Cancer, 1967Hematoporphyrin derivative has been evaluated as a means of detecting malignancy in 121 patients suspected of having cancer. Areas examined included the cervix, vagina, tracheobronchial tree, esophagus, peritoneum and rectum. Dysplastic and neoplastic tissue was identified by red fluorescence whereas nonneoplastic tissue appeared grayish white to black.
R L, Lipson, E J, Baldes, M J, Gray
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Cell biology of hematoporphyrin derivative (hpd)
Lasers in Surgery and Medicine, 1983AbstractTissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) HPD uptake, (2) HPD washout, and (3) fluorescence changes. The absorption peaks were the same for HPD in solution and HPD bound to cells. HPD was taken up by all cell types rapidly within the first 10 hours of exposure, and leveled off by 20 hours of ...
Michael W. Berns +5 more
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Hematoporphyrin Derivative Photoradiation Therapy
Archives of Ophthalmology, 1984To the Editor. —I read with interest the article in the JulyArchivesregarding hematoporphyrin derivatives in photoradiation therapy. 1 I found a number of references to this subject appearing in the literature. When I introduced porphyrins to clinical medicine in 1955, at the Johns Hopkins Hospital, Baltimore, 2 I originally used it as a surgical tool.
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