Results 151 to 160 of about 3,474 (201)

CHEMISTRY OF HEMATOPORPHYRIN‐DERIVED PHOTOSENSITIZERS

Photochemistry and Photobiology, 1987
Abstract The hematoporphyrin‐derived tumor‐localizing preparation HPD consists of porphyrin monomers, which are‘inactive’(not tumor‐localizing), and a dimer/oligomer fraction which is responsible for the localizing phenomenon. In an organic solvent system, gel‐exclusion chromatography can separate HPD into fractions containing porphyrin monomers ...
David Kessel, Paul Thompson, Brian Musselman, C. K. Chang   +3 more
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Photophysics and Photochemistry of Hematoporphyrin, Hematoporphyrin Derivative and Uroporphyrin I

1985
The putative action mechanism in photodynamic therapy (PDT) involves serum transport of HPD to tumor tissue, localization and retention of the active constituent, generation of singlet molecular oxygen (Δ) by the action of visible light and the attack of t on the cellular targets.
L I, Grossweiner, A, Blum, G C, Goyal
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Photochemotherapy mediated by hematoporphyrin derivative in gastroenterology

European Journal of Cancer and Clinical Oncology, 1987
While results concerning photodynamic treatments of cancers in pneumology or dermatology have been published regularly, few works have been devoted to gastroenterology. Twenty-seven non-operable patients bearing various G.I. tumors of less than 40 mm dia.
T, Patrice, P, Jutel, M T, Foultier, D, Cloarec, J F, Trechot, M C, Douet, L, Le Bodic   +6 more
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Two-step laser activation of hematoporphyrin derivative

Chemical Physics Letters, 1982
Abstract A new photoactivation mechanism of hematoporphyrin derivative is presented. This process, based on the sequential absorption of two photons, leads to the production of cytotoxic radicals of HpD. The cytocidal efficiency is demonstrated by in vitro experiments.
A. Andreoni, CUBEDDU, RINALDO, DE SILVESTRI, SANDRO, LAPORTA, PAOLO, SVELTO, ORAZIO   +4 more
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PHOTOSENSITIZED LYSIS OF LIPOSOMES BY HEMATOPORPHYRIN DERIVATIVE

Photochemistry and Photobiology, 1983
AbstractThe spectral properties and efficiency for photosensitizing the lysis of phosphatidylcholine liposomes have been measured for the components of hematoporphyrin derivative (Hpd) after alkaline hydrolysis and fractionation by polyacrylamidc gel chromatography.
L I, Grossweiner, G C, Goyal
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Hematoporphyrin Derivative Therapy of Papillomas: Experimental Study

Archives of Otolaryngology - Head and Neck Surgery, 1986
Hematoporphyrin derivative has been shown to selectively localize in malignant tissues and chemically induced animal papillomas. It is a powerful photo-sensitizing agent that can cause destruction and death of tissues in which it has localized by the generation of singlet oxygen when activated by light of the appropriate wavelength (photodynamic ...
M J, Shikowitz, B M, Steinberg, A L, Abramson   +2 more
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Hematoporphyrin Derivative Photochemotherapy of Experimental Bladder Tumors

Journal of Urology, 1985
Recent studies have shown that disruption of tumor blood flow is a major consequence of hematoporphyrin derivative photochemotherapy. A series of experiments was undertaken on the transplantable N-(4-(5-nitro-2-furyl)-2-thiazolyl)-formamide induced urothelial tumor in Fischer 344 rats to determine a dose response for both hematoporphyrin derivative and
S H, Selman, A J, Milligan, M, Kreimer-Birnbaum, R W, Keck, P J, Goldblatt, S L, Britton   +5 more
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LOCAL NEUROTOXICITY OF HEMATOPORPHYRIN DERIVATIVE FOLLOWING INTRACEREBRAL INJECTION

Photochemistry and Photobiology, 1995
AbstractThe present study reports on toxicity of hematoporphyrin derivative (HpD) for normal brain tissue in vivo without the addition of light. Hematoporphyrin derivative was injected by slow infusion in rat brains. Histological examination was carried out for intervals after HpD administration, ranging from 0 h to 15 days.
Noske, D. P., Kamphorst, W., Wolbers, J. G., Sterenborg, H. J.   +3 more
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Spectroscopic studies of hematoporphyrin-derivative in culture medium

Chemico-Biological Interactions, 1984
This work reports on studies of hematoporphyrin-derivative (HpD) behaviour in culture medium. Absorption, excitation and emission spectra, together with time-resolved fluorescence measurements, were performed. In previous works, similar studies had been carried out on HpD in saline and in lymphocytes: a new porphyrin species (NPS) and the environmental
G. Bottiroli, F. Docchio, I. Freitas, RAMPONI, ROBERTA, C. A. Sacchi   +4 more
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SITES OF PHOTOSENSITIZATION BY DERIVATIVES OF HEMATOPORPHYRIN

Photochemistry and Photobiology, 1986
AbstractLeukemia L1210 cells were incubatedin vitrowith the tumor‐localizing product HPD (hem‐atoporphyrin derivative) for 0.5. 4 and 18 h. Effects of subsequent irradiation on viability, membrane transport and integrity, DNA synthesis and intracellular ATP concentration were assessed. Intracellular porphyrin pools were analyzed by HPLC.
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