Results 151 to 160 of about 1,889 (199)

THE STRUCTURE OF THE ACTIVE MATERIAL IN HEMATOPORPHYRIN DERIVATIVE

Photochemistry and Photobiology, 1987
Abstract The structure of the active material in hematoporphyrin derivative is shown to be a condensation polymer of hematoporphyrin linked by ether functional groups. When a mixture of the monoacetates and the diacetate of hematoporphyrin is treated with dilute sodium hydroxide solution a polymeric fraction is formed which constitutes the active ...
C J, Byrne, L V, Marshallsay, A D, Ward
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Photophysics and Photochemistry of Hematoporphyrin, Hematoporphyrin Derivative and Uroporphyrin I

1985
The putative action mechanism in photodynamic therapy (PDT) involves serum transport of HPD to tumor tissue, localization and retention of the active constituent, generation of singlet molecular oxygen (Δ) by the action of visible light and the attack of t on the cellular targets.
L I, Grossweiner, A, Blum, G C, Goyal
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Hematoporphyrin derivatives: An oligomeric composition study

Journal of Photochemistry and Photobiology B: Biology, 1990
The oligomeric composition of HpD, Photofrin II and other hematoporphyrin derivatives useful for the diagnosis and therapy of tumors has been studied. Gel chromatographic procedures were used that excluded porphyrin aggregation. Photofrin and hematoporphyrin derivatives were shown to contain different quantities of monomer, dimer and other oligomeric ...
A F, Mironov, A N, Nizhnik, A Y, Nockel
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Bronchoscopic Phototherapy Using Hematoporphyrin Derivative

Surgical Clinics of North America, 1984
Phototherapy in the presence of hematoporphyrin (HPD) produces cytotoxicity through both energy- and power-dependent mechanisms. The resulting cellular death demonstrates the promise of HPD in the therapy of small cancers. This article reports our clinical experience and follow-up results of treating 19 patients with cancer of the tracheobronchial tree,
D A, Cortese, J H, Kinsey
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Cell biology of hematoporphyrin derivative (hpd)

Lasers in Surgery and Medicine, 1983
AbstractTissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) HPD uptake, (2) HPD washout, and (3) fluorescence changes. The absorption peaks were the same for HPD in solution and HPD bound to cells. HPD was taken up by all cell types rapidly within the first 10 hours of exposure, and leveled off by 20 hours of ...
Michael W. Berns, Marie Wilson, Robert Burns, Michael W. Berns, Alan Wile, Peter Rentzepis   +5 more
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The Photodynamic Properties of a Particular Hematoporphyrin Derivative

Archives of Dermatology, 1960
In 1898 Oscar Raab, while a student in Tappeiner's laboratory, recognized that paramecia were sensitized to light by the aniline dye, acridine. This finding led to extensive studies by Tappeiner and Jodlbauer and their associates,9,19,-21and to the introduction of the term "photodynamic action," used by Tappeiner in 1904. The use of hematoporphyrin in
R L, LIPSON, E J, BALDES
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PHOTOSENSITIZED LYSIS OF LIPOSOMES BY HEMATOPORPHYRIN DERIVATIVE

Photochemistry and Photobiology, 1983
AbstractThe spectral properties and efficiency for photosensitizing the lysis of phosphatidylcholine liposomes have been measured for the components of hematoporphyrin derivative (Hpd) after alkaline hydrolysis and fractionation by polyacrylamidc gel chromatography.
L I, Grossweiner, G C, Goyal
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The Structure of the Active Component of Hematoporphyrin Derivative

1984
Photoradiation therapy (PRT) for local treatment of malignant tumors utilizing hematoporphyrin derivative (Hpd) as photosensitizing drug is undergoing clinical trials in several centers in the U. S. and abroad. This therapy is based on the localization and retention of Hpd in most tumors, as well as its photodynamic action which likely generates ...
T J, Dougherty, W R, Potter, K R, Weishaupt   +2 more
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SITES OF PHOTOSENSITIZATION BY DERIVATIVES OF HEMATOPORPHYRIN

Photochemistry and Photobiology, 1986
AbstractLeukemia L1210 cells were incubatedin vitrowith the tumor‐localizing product HPD (hem‐atoporphyrin derivative) for 0.5. 4 and 18 h. Effects of subsequent irradiation on viability, membrane transport and integrity, DNA synthesis and intracellular ATP concentration were assessed. Intracellular porphyrin pools were analyzed by HPLC.
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Pharmacokinetic Studies of Hematoporphyrin Derivatives on Rat Hepatocytes. Protoporphyrin Dimethyl Ester Hematoporphyrin Ether versus Dihematoporphyrin Ether-Free Hematoporphyrin Derivative

Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both, H, Häberlein, A M, Gressner, I, Sieg, M O, Doss   +4 more
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