Results 151 to 160 of about 321,886 (190)
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SITES OF PHOTOSENSITIZATION BY DERIVATIVES OF HEMATOPORPHYRIN
Photochemistry and Photobiology, 1986AbstractLeukemia L1210 cells were incubatedin vitrowith the tumor‐localizing product HPD (hem‐atoporphyrin derivative) for 0.5. 4 and 18 h. Effects of subsequent irradiation on viability, membrane transport and integrity, DNA synthesis and intracellular ATP concentration were assessed. Intracellular porphyrin pools were analyzed by HPLC.
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Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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CHEMISTRY OF HEMATOPORPHYRIN‐DERIVED PHOTOSENSITIZERS
Photochemistry and Photobiology, 1987Abstract The hematoporphyrin‐derived tumor‐localizing preparation HPD consists of porphyrin monomers, which are‘inactive’(not tumor‐localizing), and a dimer/oligomer fraction which is responsible for the localizing phenomenon. In an organic solvent system, gel‐exclusion chromatography can separate HPD into fractions containing porphyrin monomers ...
David Kessel +3 more
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Photochemistry and Photobiology, 1987
AbstractA ternary‐solvent HPLC method for analysis of the components of the tumor‐localizing product HPD is described. This HPLC system was used to assess the utility of a new method, based on gel exclusion chromatography, for purification of hematoporphyrin.
D, Kessel, P, Thompson
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AbstractA ternary‐solvent HPLC method for analysis of the components of the tumor‐localizing product HPD is described. This HPLC system was used to assess the utility of a new method, based on gel exclusion chromatography, for purification of hematoporphyrin.
D, Kessel, P, Thompson
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Journal of Photochemistry and Photobiology B: Biology, 1988
The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes.
M, Shopova, T, Gantchev
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The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes.
M, Shopova, T, Gantchev
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Hematoporphyrin Derivative Phototherapy in the Treatment of Bronchogenic Carcinoma
Chest, 1984Nineteen patients with cancer involving the tracheobronchial tree (a total of 20 carcinomas) have completed at least one course of hematoporphyrin derivative phototherapy administered via the flexible fiberoptic bronchoscope. Seven patients (eight carcinomas) have shown a complete response. In six of these patients (seven carcinomas), there has been no
D A, Cortese, J H, Kinsey
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A Chromatographic Study of Hematoporphyrin Derivatives
1984Hematoporphyrin derivative (Hpd), a porphyrin mixture first introduced as a tumorlocalizer by Lipson et al. is the most widely used drug in clinical trials for photoradiation therapy (PRT) of cancer. Furthermore, due to its fluorescence and tumorlocalizing properties, it may be used in cancer diagnosis1–5.
Stein Sommer +3 more
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Membrane photosensitization by hematoporphyrin and hematoporphyrin derivative.
Progress in clinical and biological research, 1985HPD-A, the putative active biologic component of HPD, photosensitized lysis of large phosphatidylcholine liposomes and lipid peroxidation in small liposomes with oxygen enhancement ratios from 4 to 5. Unambiguous proof was obtained that this damage was mediated by singlet oxygen.
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Two-step laser activation of hematoporphyrin derivative
Chemical Physics Letters, 1982Abstract A new photoactivation mechanism of hematoporphyrin derivative is presented. This process, based on the sequential absorption of two photons, leads to the production of cytotoxic radicals of HpD. The cytocidal efficiency is demonstrated by in vitro experiments.
A. Andreoni +4 more
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PHOTOSENSITIZING EFFECTS OF HEMATOPORPHYRIN DERIVATIVE IMMOBILIZED ON SEPHAROSE
Photochemistry and Photobiology, 1987Abstract— The cytotoxicity that ensues following photosensitization by hematoporphyrin derivative (Hpd) is attributed to production of singlet oxygen. Many of the cellular end points reported to be affected are localized to membranes, hydrophobic environments conducive to partitioning of hydrophobic porphyrins in Hpd.
S L, Gibson, R S, Murant, R, Hilf
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