Results 171 to 180 of about 3,474 (201)

Hematoporphyrin Derivative: Fluorometric Studies in Solution and Cells

1984
Hematoporphyrin Derivative (HpD) is a mixture of porphyrins, widely used in detection and therapy of cancer1,2. HpD was introduced in 1961 by Lipson et al.3 as a better tumor-locating drug than Hematoporphyrin (Hp). They proposed that the crude Hp be treated with a mixture of acetic acid and sulfuric acid, followed by adjustment of the final pH to ...
Giovanni Bottiroli, DOCCHIO, Franco, Isabel Freitas, Roberta Ramponi, Carlo A. Sacchi   +4 more
openaire   +2 more sources

Chemical, Biologic and Biophysical Studies on ‘Hematoporphyrin Derivative’

1985
This article will describe procedures for fractionation, analysis, and chemical, biological and biophysical characterization of the tumor-localizing product HPD. Since the latter is a mixture of different porphyrins, many of the early studies on HPD represent composite results.
D, Kessel, C K, Chang, B, Musselman
openaire   +2 more sources

Hematoporphyrin Derivative Phototherapy in Experimental Oncology

1984
Photoradiation therapy is currently under investigation as a new form of treatment for solid malignant tumors in human. The method involves photosensitization of drugs and fluorescent dyes, such as Hematoporphyrin1. This dye has been shown to accumulate with a certain degree of specificity in tissues with a high mitotic index2.
Gianfranco Canti, Laura Ricci, Paola Franco, Angelo Nicolin, Alessandra Andreoni, Rinaldo Cubeddu   +5 more
openaire   +1 more source

Parameters of hematoporphyrin derivative tumor cell killing efficiency: decomposition of hematoporphyrin derivative at high power densities.

Progress in clinical and biological research, 1985
Hematoporphyrin derivative (HpD) tumor cell killing efficiency has been evaluated as a function of power density, optical spectrum, HpD concentration, and HpD preparation using trypan blue exclusion assay. Cell survival curves for Mayo Clinic HpD and for Photofrin were equivalent at all concentrations and power densities for both violet and red light ...
R E, Anderson, R E, Wharen, C A, Jones, E R, Laws   +3 more
openaire   +1 more source

[Synergism of hyperthermia and hematoporphyrin derivative].

Gan to kagaku ryoho. Cancer & chemotherapy, 1984
Much attention has been given to the photoradiation therapy, since its mechanism of effect is thought to be due to the cytotoxicity of singlet oxygen produced from hematoporphyrin derivative (HPD) by the light. We studied the effects of hyperthermia (HT) on cultured cells (T1) of ethylnitrosourea induced rat brain tumor which had uptaken HPD, because ...
H, Gi, J, Yamashita, H, Handa
openaire   +1 more source

Hematoporphyrin Derivative

2011
openaire   +1 more source

Hematoporphyrin Derivative

2008
openaire   +1 more source

Superoxide, hydrogen peroxide and singlet oxygen in hematoporphyrin derivative-cysteine, -NADH and -light systems

Biochimica Et Biophysica Acta - General Subjects, 1987
Garry R Buettner
exaly  

Chemistry of hematoporphyrin-derived photosensitizers.

Photochemistry and photobiology, 1988
D, Kessel, P, Thompson, B, Musselman, C K, Chang   +3 more
openaire   +1 more source

The interaction of hematoporphyrin derivative, light, and ionizing radiation in a rat glioma model

Cancer, 1986
Douglas C Miller
exaly