Results 171 to 180 of about 1,889 (199)
Some of the next articles are maybe not open access.
Membrane photosensitization by hematoporphyrin and hematoporphyrin derivative.
Progress in clinical and biological research, 1985HPD-A, the putative active biologic component of HPD, photosensitized lysis of large phosphatidylcholine liposomes and lipid peroxidation in small liposomes with oxygen enhancement ratios from 4 to 5. Unambiguous proof was obtained that this damage was mediated by singlet oxygen.
openaire +1 more source
Hematoporphyrin derivative: experimental evidence for aggregated species
Chemical Physics Letters, 1982Abstract Absorption and fluorescence properties of hematoporphyrin derivative in different solvent systems are investigated. The presence of a large amount of stable aggregates is demonstrated. The existence of these aggregates represents one major difference between hematoporphyrin derivative and hematoporphyrin free base.
A. Andreoni +5 more
openaire +2 more sources
Uptake of the components of hematoporphyrin derivative by cells and tumours
Cancer Letters, 1983The porphyrin content of cells labelled with hematoporhyrin derivative (Hpd) and tumours of mice injected with Hpd was analysed by means of high pressure liquid chromatography (HPLC). The components of Hpd may be classified in 3 groups: (A) Components with a high fluorescence quantum yield and with sharp peaks in the HPLC chromatogram.
J, Moan, S, Sommer
openaire +2 more sources
Bactericidal Effects of Photoradiation Therapy With Hematoporphyrin Derivative
Journal of Infectious Diseases, 1985Hematoporphyrin derivative (Hpd) localizes selectively in malignant and rapidly metabolizing tissues and undergoes a cytotoxic reaction when exposed to light of a specific wavelength. Hpd has been studied extensively with regard to the diagnosis and treatment of tumors but not with regard to bactericidal activity. This investigation assessed the effect
F R, Venezio +6 more
openaire +2 more sources
Hematoporphyrin Derivative in the Diagnosis and Treatment of Lung Cancer
1983Since 1978 we have studied the properties of hematopor-phyrin derivative (HPD) and have sought means to improve the drug as well as the instrumentation used in both diagnostic and therapeutic clinical procedures (1–3).
R G, Vincent +3 more
openaire +2 more sources
Hematoporphyrin Derivative: Fluorometric Studies in Solution and Cells
1984Hematoporphyrin Derivative (HpD) is a mixture of porphyrins, widely used in detection and therapy of cancer1,2. HpD was introduced in 1961 by Lipson et al.3 as a better tumor-locating drug than Hematoporphyrin (Hp). They proposed that the crude Hp be treated with a mixture of acetic acid and sulfuric acid, followed by adjustment of the final pH to ...
Giovanni Bottiroli +4 more
openaire +2 more sources
[Synergism of hyperthermia and hematoporphyrin derivative].
Gan to kagaku ryoho. Cancer & chemotherapy, 1984Much attention has been given to the photoradiation therapy, since its mechanism of effect is thought to be due to the cytotoxicity of singlet oxygen produced from hematoporphyrin derivative (HPD) by the light. We studied the effects of hyperthermia (HT) on cultured cells (T1) of ethylnitrosourea induced rat brain tumor which had uptaken HPD, because ...
H, Gi, J, Yamashita, H, Handa
openaire +1 more source
The synthesis and characterization of 111in hematoporphyrin derivative
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1986D K, Lavallee, R, Fawwaz
openaire +2 more sources
Photodynamic therapy with hematoporphyrin derivative in cancer of the upper gastrointestinal tract
Journal of Surgical Oncology, 1985Yoshihiro Hayata +2 more
exaly