Results 161 to 170 of about 1,889 (199)

CHEMISTRY OF HEMATOPORPHYRIN‐DERIVED PHOTOSENSITIZERS

Photochemistry and Photobiology, 1987
Abstract The hematoporphyrin‐derived tumor‐localizing preparation HPD consists of porphyrin monomers, which are‘inactive’(not tumor‐localizing), and a dimer/oligomer fraction which is responsible for the localizing phenomenon. In an organic solvent system, gel‐exclusion chromatography can separate HPD into fractions containing porphyrin monomers ...
David Kessel, Paul Thompson, Brian Musselman, C. K. Chang   +3 more
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Comparative study of the therapeutic effect of photoactivated hematoporphyrin derivative and aluminum disulfonated phthalocyanines on tumor bearing mice

Cancer Letters, 1990
Although the hematoporphyrin derivative (Hpd) is one of the most studied photosensitisers for photodynamic therapy (PDT), it is far from ideal. Therefore, many laboratories have been investigating a new group of sensitisers, the phthalocyanines ...
G Canti, Paola Taroni, Roberta Ramponi   +2 more
exaly   +2 more sources

Influence of medium polarity on the photosensitizing properties of hematoporphyrin and hematoporphyrin derivative (Photofrin II)

Journal of Photochemistry and Photobiology B: Biology, 1988
The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes.
M, Shopova, T, Gantchev
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PURIFICATION and ANALYSIS OF HEMATOPORPHYRIN and HEMATOPORPHYRIN DERIVATIVE BY GEL EXCLUSION and REVERSE‐PHASE CHROMATOGRAPHY*

Photochemistry and Photobiology, 1987
AbstractA ternary‐solvent HPLC method for analysis of the components of the tumor‐localizing product HPD is described. This HPLC system was used to assess the utility of a new method, based on gel exclusion chromatography, for purification of hematoporphyrin.
D, Kessel, P, Thompson
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Hematoporphyrin‐Derivative and Photoradiation Therapy of Malignant Tumors

Lasers in Surgery and Medicine, 1983
AbstractKodak projectors with #2418 red Corning filters were used as a light source to treat cutaneous and subcutaneous malignancies in five patients who previously had been given hematoporphyrin derivative (HpD). An argon dye laser system was used to treat malignancies in patients who also were given the HpD.
J S, McCaughan, J T, Guy, P, Hawley, W, Hicks, W, Inglis, L, Laufman, E, May, T A, Nims, R, Sherman   +8 more
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Hematoporphyrin Derivative Phototherapy in the Treatment of Bronchogenic Carcinoma

Chest, 1984
Nineteen patients with cancer involving the tracheobronchial tree (a total of 20 carcinomas) have completed at least one course of hematoporphyrin derivative phototherapy administered via the flexible fiberoptic bronchoscope. Seven patients (eight carcinomas) have shown a complete response. In six of these patients (seven carcinomas), there has been no
D A, Cortese, J H, Kinsey
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A Chromatographic Study of Hematoporphyrin Derivatives

1984
Hematoporphyrin derivative (Hpd), a porphyrin mixture first introduced as a tumorlocalizer by Lipson et al. is the most widely used drug in clinical trials for photoradiation therapy (PRT) of cancer. Furthermore, due to its fluorescence and tumorlocalizing properties, it may be used in cancer diagnosis1–5.
Stein Sommer, Johan Moan, Terje Christensen, Jan F. Evensen   +3 more
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Hematoporphyrin Derivative Therapy of Papillomas: Experimental Study

Archives of Otolaryngology - Head and Neck Surgery, 1986
Hematoporphyrin derivative has been shown to selectively localize in malignant tissues and chemically induced animal papillomas. It is a powerful photo-sensitizing agent that can cause destruction and death of tissues in which it has localized by the generation of singlet oxygen when activated by light of the appropriate wavelength (photodynamic ...
M J, Shikowitz, B M, Steinberg, A L, Abramson   +2 more
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Two-step laser activation of hematoporphyrin derivative

Chemical Physics Letters, 1982
Abstract A new photoactivation mechanism of hematoporphyrin derivative is presented. This process, based on the sequential absorption of two photons, leads to the production of cytotoxic radicals of HpD. The cytocidal efficiency is demonstrated by in vitro experiments.
A. Andreoni, CUBEDDU, RINALDO, DE SILVESTRI, SANDRO, LAPORTA, PAOLO, SVELTO, ORAZIO   +4 more
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PHOTOSENSITIZING EFFECTS OF HEMATOPORPHYRIN DERIVATIVE IMMOBILIZED ON SEPHAROSE

Photochemistry and Photobiology, 1987
Abstract— The cytotoxicity that ensues following photosensitization by hematoporphyrin derivative (Hpd) is attributed to production of singlet oxygen. Many of the cellular end points reported to be affected are localized to membranes, hydrophobic environments conducive to partitioning of hydrophobic porphyrins in Hpd.
S L, Gibson, R S, Murant, R, Hilf
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