Results 141 to 150 of about 321,886 (190)

Hematoporphyrin and hematoporphyrin-derivative photosensitization of mitochondria

Biochimie, 1986
Laser micro-irradiation experiments show that mitochondria are profoundly affected when cells are irradiated with Hp as the photosensitizer. Functional as well as enzymatic studies on isolated mitochondria show that coupling between respiration and oxidative phosphorylation, Ca2+ transport and respiration are successively lost under irradiation in the ...
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The main photosensitizing components of hematoporphyrin derivative

Cancer Letters, 1982
Commercial hematoporphyrin (Hp) and the tumor-localizing and photosensitizing agent hematoporphyrin derivative (Hpd) were analysed by means of high pressure lipid chromatography (HPLC). Furthermore, their efficiencies in sensitizing the photoinactivation of human cells in vitro were compared. The comparison showed that the least polar components of Hpd
J, Moan, T, Christensen, S, Sommer
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Photochemotherapy mediated by hematoporphyrin derivative in gastroenterology

European Journal of Cancer and Clinical Oncology, 1987
While results concerning photodynamic treatments of cancers in pneumology or dermatology have been published regularly, few works have been devoted to gastroenterology. Twenty-seven non-operable patients bearing various G.I. tumors of less than 40 mm dia.
T, Patrice, P, Jutel, M T, Foultier, D, Cloarec, J F, Trechot, M C, Douet, L, Le Bodic   +6 more
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Photophysics and Photochemistry of Hematoporphyrin, Hematoporphyrin Derivative and Uroporphyrin I

1985
The putative action mechanism in photodynamic therapy (PDT) involves serum transport of HPD to tumor tissue, localization and retention of the active constituent, generation of singlet molecular oxygen (Δ) by the action of visible light and the attack of t on the cellular targets.
L I, Grossweiner, A, Blum, G C, Goyal
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The Photodynamic Properties of a Particular Hematoporphyrin Derivative

Archives of Dermatology, 1960
In 1898 Oscar Raab, while a student in Tappeiner's laboratory, recognized that paramecia were sensitized to light by the aniline dye, acridine. This finding led to extensive studies by Tappeiner and Jodlbauer and their associates,9,19,-21and to the introduction of the term "photodynamic action," used by Tappeiner in 1904. The use of hematoporphyrin in
R L, LIPSON, E J, BALDES
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PHOTOSENSITIZED LYSIS OF LIPOSOMES BY HEMATOPORPHYRIN DERIVATIVE

Photochemistry and Photobiology, 1983
AbstractThe spectral properties and efficiency for photosensitizing the lysis of phosphatidylcholine liposomes have been measured for the components of hematoporphyrin derivative (Hpd) after alkaline hydrolysis and fractionation by polyacrylamidc gel chromatography.
L I, Grossweiner, G C, Goyal
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THE STRUCTURE OF THE ACTIVE MATERIAL IN HEMATOPORPHYRIN DERIVATIVE

Photochemistry and Photobiology, 1987
Abstract The structure of the active material in hematoporphyrin derivative is shown to be a condensation polymer of hematoporphyrin linked by ether functional groups. When a mixture of the monoacetates and the diacetate of hematoporphyrin is treated with dilute sodium hydroxide solution a polymeric fraction is formed which constitutes the active ...
C J, Byrne, L V, Marshallsay, A D, Ward
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Hematoporphyrin derivatives: An oligomeric composition study

Journal of Photochemistry and Photobiology B: Biology, 1990
The oligomeric composition of HpD, Photofrin II and other hematoporphyrin derivatives useful for the diagnosis and therapy of tumors has been studied. Gel chromatographic procedures were used that excluded porphyrin aggregation. Photofrin and hematoporphyrin derivatives were shown to contain different quantities of monomer, dimer and other oligomeric ...
A F, Mironov, A N, Nizhnik, A Y, Nockel
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The Structure of the Active Component of Hematoporphyrin Derivative

1984
Photoradiation therapy (PRT) for local treatment of malignant tumors utilizing hematoporphyrin derivative (Hpd) as photosensitizing drug is undergoing clinical trials in several centers in the U. S. and abroad. This therapy is based on the localization and retention of Hpd in most tumors, as well as its photodynamic action which likely generates ...
T J, Dougherty, W R, Potter, K R, Weishaupt   +2 more
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Bronchoscopic Phototherapy Using Hematoporphyrin Derivative

Surgical Clinics of North America, 1984
Phototherapy in the presence of hematoporphyrin (HPD) produces cytotoxicity through both energy- and power-dependent mechanisms. The resulting cellular death demonstrates the promise of HPD in the therapy of small cancers. This article reports our clinical experience and follow-up results of treating 19 patients with cancer of the tracheobronchial tree,
D A, Cortese, J H, Kinsey
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