Results 141 to 150 of about 3,474 (201)

Hematoporphyrin derivative: experimental evidence for aggregated species

Chemical Physics Letters, 1982
Abstract Absorption and fluorescence properties of hematoporphyrin derivative in different solvent systems are investigated. The presence of a large amount of stable aggregates is demonstrated. The existence of these aggregates represents one major difference between hematoporphyrin derivative and hematoporphyrin free base.
A. Andreoni, CUBEDDU, RINALDO, DE SILVESTRI, SANDRO, G. Jori, LAPORTA, PAOLO, E. Reddi   +5 more
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Zinc hematoporphyrin in preparations of hematoporphyrin and hematoporphyrin derivative

Chemical Physics Letters, 1984
Abstract The blue-shifted emission from aged aqueous solutions of hematoporphyrin and its derivatives, reported by others to originate from special aggregates, is shown to originate from the zinc chelates of the porphyrins. Suggestions are made regarding the role of such zinc porphyrins in the localization of hematoporphyrin and its derivatives in ...
A.A. Lamola, M. Sassaroli
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Tumor Fluorescence with Hematoporphyrin Derivative

Annals of Otology, Rhinology & Laryngology, 1977
Hematoporphyrin derivative (HpD) is one of several photodynamically active dyes that accumulate in tumor cells and can be used to differentiate neoplastic from normal tissue by violet light activation. Degree of tumor fluorescence was studied in relation to the nature of the hematoporphyrin compound, dose of HpD injected, route of injection, and ...
R J, Carpenter, H B, Neel, R J, Ryan, D R, Sanderson   +3 more
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Hematoporphyrin Derivative Photoradiation Therapy

Archives of Ophthalmology, 1984
To the Editor. —I read with interest the article in the JulyArchivesregarding hematoporphyrin derivatives in photoradiation therapy. 1 I found a number of references to this subject appearing in the literature. When I introduced porphyrins to clinical medicine in 1955, at the Johns Hopkins Hospital, Baltimore, 2 I originally used it as a surgical tool.
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Bronchoscopic Phototherapy Using Hematoporphyrin Derivative

Surgical Clinics of North America, 1984
Phototherapy in the presence of hematoporphyrin (HPD) produces cytotoxicity through both energy- and power-dependent mechanisms. The resulting cellular death demonstrates the promise of HPD in the therapy of small cancers. This article reports our clinical experience and follow-up results of treating 19 patients with cancer of the tracheobronchial tree,
D A, Cortese, J H, Kinsey
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Cell biology of hematoporphyrin derivative (hpd)

Lasers in Surgery and Medicine, 1983
AbstractTissue culture cells were treated with hematoporphyrin derivative (HPD) and analyzed for (1) HPD uptake, (2) HPD washout, and (3) fluorescence changes. The absorption peaks were the same for HPD in solution and HPD bound to cells. HPD was taken up by all cell types rapidly within the first 10 hours of exposure, and leveled off by 20 hours of ...
Michael W. Berns, Marie Wilson, Robert Burns, Michael W. Berns, Alan Wile, Peter Rentzepis   +5 more
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Hematoporphyrin derivatives: An oligomeric composition study

Journal of Photochemistry and Photobiology B: Biology, 1990
The oligomeric composition of HpD, Photofrin II and other hematoporphyrin derivatives useful for the diagnosis and therapy of tumors has been studied. Gel chromatographic procedures were used that excluded porphyrin aggregation. Photofrin and hematoporphyrin derivatives were shown to contain different quantities of monomer, dimer and other oligomeric ...
A F, Mironov, A N, Nizhnik, A Y, Nockel
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Pharmacokinetic Studies of Hematoporphyrin Derivatives on Rat Hepatocytes. Protoporphyrin Dimethyl Ester Hematoporphyrin Ether versus Dihematoporphyrin Ether-Free Hematoporphyrin Derivative

Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both, H, Häberlein, A M, Gressner, I, Sieg, M O, Doss   +4 more
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Hematoporphyrin and hematoporphyrin-derivative photosensitization of mitochondria

Biochimie, 1986
Laser micro-irradiation experiments show that mitochondria are profoundly affected when cells are irradiated with Hp as the photosensitizer. Functional as well as enzymatic studies on isolated mitochondria show that coupling between respiration and oxidative phosphorylation, Ca2+ transport and respiration are successively lost under irradiation in the ...
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The Analysis of Hematoporphyrin Derivative

1983
When work on photoradiation therapy (PRT) commenced in Adelaide, the stringency of Australian Federal drug regulations made it preferable for us to prepare HPD rather than import the product. It was therefore important that we have an acceptable assay for both HPD solid and HPD clinical1, thereby enabling comparisons between our material and the ...
P A, Cadby, E, Dimitriadis, H G, Grant, A D, Ward, I J, Forbes   +4 more
openaire   +2 more sources